Conservative Dentistry

Triple Antibiotic Paste is an intracanal medicament used primarily in regenerative endodontics and for disinfecting necrotic root canals.

 Composition:

• Ciprofloxacin – targets Gram-negative bacteria

• Metronidazole – effective against anaerobes

• Minocycline – broad-spectrum, but may cause tooth discoloration

Uses:

• Disinfection in immature teeth with necrotic pulps

• Regenerative procedures like revascularization

• Lesion sterilization and tissue repair (LSTR)

Limitations:

• Tooth discoloration (especially from minocycline)

• Potential cytotoxicity to stem cells

• Alternatives include double antibiotic paste or modified TAP (replacing minocycline with clindamycin or cefaclor)