Oral Pathology

• Schilling Test: Done to identify the deficiency of either extrinsic (dietary vitamin B12) or intrinsic factor involved in Pernicious Anemia.

• Fanconi's Syndrome: Associated with Aplastic Anemia.

• "Safety-Pin" Cells: Characteristic finding in Thalassemia / Erythroblastic Anemia.

• Radiographic Features of Anemias:

  • "Salt and Pepper" effect (Intraoral Periapical Radiograph): Found in Cooley's Anemia (Thalassemia) and Sickle Cell Anemia.

  • "Hair-on-End" pattern (Skull Radiograph): Found in Thalassemia, Sickle Cell Anemia, Congenital Hemolytic Jaundice, Chronic Iron Deficiency Anemia.

• "Rh Hump" (Erythroblastosis Fetalis): Describes a ring-like defect.

• Plummer-Vinson Syndrome: Associated with Iron Deficiency Anemia.

• Chediak-Higashi Syndrome: Giant abnormal PAS positive granules found in peripheral circulating leukocytes are basically altered lysosomes.

• Philadelphia Chromosome: Translocation of chromosomal material from chromosome 22 to chromosome 9; found in Chronic Myeloid Leukemia (CML).