What are the two main clinical hallmarks of Huntington's disease?
(1) Parkinsonism and tremor
(2) Chorea and cognitive impairment
(3) Ataxia and peripheral neuropathy
(4) Dystonia and rigidity
📝 Explanation:
Huntington's disease is characterized by two main clinical features: chorea (involuntary, irregular, and sudden jerky movements) and behavioral disturbances. These symptoms may occur alone or in combination, with the choreic movement disorder typically becoming more pronounced over time.