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State PSC PYQ - 3 Questions
Which of the following cytokines is predominantly involved in the pathogenesis of Oral Lichen Planus?
Oral lichen planus is a T-cell mediated autoimmune disease. IFN-γ and TNF-α are present in lesions and involved in its pathogenesis. IFN-γ is the key cytokine in cellular immune response.
Splinting severely mobile teeth in the presence of active periodontal inflammation is contraindicated. Splinting should only be done after inflammation control.
What is the primary process involved in bone remodeling during craniofacial development?
Bone remodeling is a continuous, lifelong process that involves the removal (resorption) of old or damaged bone by osteoclasts and the formation (deposition) of new bone material by osteoblasts. This coupled activity is essential for maintaining the structural integrity of the skeleton and adapting to mechanical stress (Wolff's Law). While intramembranous and endochondral ossification are the two main processes of initial bone formation during development, the ongoing changes and reshaping of the bone structure after its initial formation, including during craniofacial development, occur through this dynamic balance of resorption and deposition.