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Pathology NEET MDS Practice Test
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Pathology - 3 Questions

1
Pathology

The Philadelphia chromosome, characteristic of CML, results from a translocation between which genes/chromosomes?
1) myc on chromosome 8 and Ig heavy chain on chromosome 14
2) bcr on chromosome 9 and abl on chromosome 22
3) bcl-2 on chromosome 18 and Ig heavy chain on chromosome 14
4) PML on chromosome 15 and RARA on chromosome 17

📝 Explanation:

Correct answer: B) CML is characterized by t(9;22), fusing the bcr gene (chromosome 9) with abl (chromosome 22) to form the Philadelphia chromosome. The resulting BCR-ABL fusion protein has constitutive tyrosine kinase activity, driving leukemogenesis.

2
Pathology
Osmotic fragility is increased in -
1) Sickle cell anaemia
2) Thalassemia
3) Hereditary spherocytosis
4) Chronic lead poisoning

📝 Explanation:

Osmotic fragility is increased in hereditary spherocytosis due to the abnormal shape and membrane stability of red blood cells.

3
Pathology

Which of the following is NOT a characteristic of MEN IIA?
1) Medullary thyroid carcinoma
2) Pheochromocytoma
3) Parathyroid adenomas
4) Mucosal neuromas

📝 Explanation:

Mucosal neuromas are not a characteristic of MEN IIA; they are associated with MEN IIB.

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