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NEET MDS Quiz - Practice Test
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Pathology - 3 Questions

1
Pathology

The migration of leukocytes from intravascular to extra vascular compartment occurs through:
1). Desmosomic destruction
2). Enlargement of interendothelial Junctions
3). Endothelial pores
4). Transmembrane proteins

πŸ“ Explanation:

Enlargement of interendothelial junctions: This option refers to the widening of the spaces between endothelial cells, which can occur during inflammation. This enlargement allows leukocytes to pass through the endothelium more easily. This is a significant mechanism in the process of leukocyte transmigration.

2
Pathology

The major stimulator of monocytes
1. IL-I
2. ã-interferon
3. IgE
4. lgG

πŸ“ Explanation:

1. Interleukin-1 (IL-1): Interleukin-1 is a pro-inflammatory cytokine that plays a crucial role in the activation and regulation of the immune system. It is produced mainly by macrophages and monocytes in response to various stimuli, including bacterial endotoxins, viruses, and tissue damage. IL-1 is a major stimulator of monocytes, as it promotes their proliferation, differentiation into macrophages, and enhances their phagocytic and antigen-presenting capabilities. It also induces the production of other cytokines, such as TNF-alpha and IL-6, which further amplify the inflammatory response. Thus, it acts as a critical mediator in the early stages of the immune response and is involved in the initiation of the acute phase reaction.

2. α-Interferon: Interferons (IFNs) are a family of cytokines that play an essential role in the innate immune response to viral infections. They are mainly produced by cells in response to viral infection and can induce an antiviral state in nearby cells by upregulating the expression of proteins that inhibit viral replication. While α-interferon does not directly stimulate monocytes, it does have some effects on the immune system, such as enhancing the natural killer (NK) cell activity and modulating the function of macrophages and other immune cells. However, it is not the primary stimulator of monocytes like IL-1 is.

3. Immunoglobulin E (IgE): IgE is a class of antibodies that are involved in the allergic response and the immune response to parasites. It is produced in response to allergens and parasitic antigens. While IgE is important in the activation of mast cells and basophils, which play a key role in the immediate allergic response, it does not serve as a major stimulator of monocytes. Monocytes are more closely associated with the innate immune response and are not primarily activated by antibodies.

4. Immunoglobulin G (IgG): IgG is the most abundant and versatile class of antibodies in the blood. It plays a pivotal role in the immune response by binding to pathogens and facilitating their destruction through various mechanisms, such as opsonization (enhancing phagocytosis), activation of the complement system, and neutralization of toxins. IgG can interact with macrophages via Fcγ receptors, which can lead to phagocytosis of antigen-antibody complexes. However, IgG is not a direct stimulator of monocytes in the same sense that IL-1 is. Monocytes are primarily activated by cytokines and other signaling molecules released during inflammation and infection, rather than by antibodies.

3
Pathology

A malignant tumour cell moves through the stages of:
1. Progression ¨ vascularization ¨ invasion ¨ detachment ¨ embolization
2. Vascularization ¨ invasion ¨ prepression ¨ detachment ¨ embolization
3. invasion¨ vascularization¨progression ¨ detachment ¨ embolization
4. Detachment ¨invasion ¨ vascularization ¨ progression ¨ embolization

πŸ“ Explanation:

The correct answer is: 1. Progression ¨ vascularization ¨ invasion ¨ detachment ¨ embolization.

Explanation of the stages for a malignant tumor cell:

1. Progression: This is the initial stage of tumor development where the cells acquire the ability to proliferate in an uncontrolled manner. This can be due to genetic mutations that alter the normal regulatory mechanisms that control cell division. The tumor grows locally within the tissue or organ of origin.

2. Vascularization: Also known as angiogenesis, this stage involves the formation of new blood vessels that supply the tumor with nutrients and oxygen, which is essential for its continued growth and progression. The tumor cells secrete factors that stimulate the growth of blood vessels into the tumor mass.

3. Invasion: The malignant tumor cells develop the capability to invade surrounding tissues. They secrete enzymes that degrade the extracellular matrix and basement membrane, allowing them to move through these barriers and invade neighboring tissues and organs.

4. Detachment: During this stage, tumor cells detach from the primary tumor site. This is facilitated by the loss of cell-to-cell adhesion molecules and the degradation of the extracellular matrix by proteolytic enzymes.

5. Embolization: Detached tumor cells can then enter the lymphatic system or bloodstream. This process is known as intravasation. They travel through these vessels as emboli and can potentially form new tumors at distant sites, which is the process of metastasis.

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