A doctor, while drawing blood for an HIV positive patient experienced a needle stick injury. The best prophylaxis which is to be given is
1) Zidovudine + Lamivudine for 4 weeks
2) Zidovudine + Lamivudine + Indinavir for 4 weeks
3) Zidovudine + Lamivudine + Nevirapine for 4 weeks
4) Zidovudine + Stavudine + Nevirapine for 4 weeks
π Explanation:
PEP should be started as soon as possible (preferably within 2 hours, and not later than 72 hours).
The duration is 28 days (4 weeks).
The recommended regimen is a triple-drug combination to maximize efficacy and reduce the risk of resistance.
Zidovudine (AZT) + Lamivudine (3TC): These are nucleoside reverse transcriptase inhibitors (NRTIs) and form the backbone of most HIV prophylaxis regimens.
Indinavir: A protease inhibitor, added to strengthen the regimen and provide a third mechanism of action.
Together, this triple therapy is recommended for occupational exposure to HIV-positive blood
MCQ