In the context of antitubercular therapy, which of the following is true about the metabolism of isoniazid and streptomycin?
(1) Both are metabolized in the liver
(2) Both are metabolized in the kidneys
(3) Isoniazid is metabolized in the liver, while streptomycin is metabolized in the kidneys
(4) Isoniazid is metabolized in the kidneys, while streptomycin is metabolized in the liver
π Explanation:
Isoniazid is metabolized by the liver, while streptomycin is metabolized by the kidneys. This is important to consider when administering these drugs, especially in patients with hepatic or renal impairment.