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Pedodontics
Histodifferentiation & Morphodifferentiation
6 Main Stages:
- Initiation (6-7 weeks IU)
- Proliferation (8 weeks IU)
- Histodifferentiation (9-10 weeks IU)
- Morphodifferentiation (11-12 weeks IU)
- Apposition (varies by tooth)
- Calcification (varies by tooth)
Key Molecular Signals:
- BMP: Bone Morphogenetic Proteins
- FGF: Fibroblast Growth Factors
- Wnt: Wingless signaling pathway
- MSX1, MSX2: Homeobox genes
- PAX9: Transcription factor