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General Medicine
Chronic lymphocytic leukemia is characterized by the accumulation of mature-looking but functionally incompetent lymphocytes in the blood, bone marrow, and lymphoid tissues. Common physical examination findings include splenomegaly, lymphadenopath
Pathology
Indirect chemical carcinogens differ from direct acting agents in that they require metabolic activation to exert their carcinogenic effects. This means that indirect carcinogens must undergo a chemical transformation within the body before
General Medicine
Histamine is a potent vasodilator and increases vascular permeability, contributing to the vasodilatory shock and hypotension seen in anaphylaxis. It also causes bronchoconstriction but is primarily responsible for the vasodilatory component.
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