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Pharmacology

Adverse Drug Reactions in Dentistry: Lichenoid Reaction & Anaphylaxis

NEET MDSINI-CET MDSINBDE

This high-yield revision note on Adverse Drug Reactions in Dentistry: Lichenoid Reaction & Anaphylaxis covers everything examiners typically test under Pharmacology — structured as quick-reference tables, clinical correlations, mnemonics and previous-year-style high-yield points. It's built for last-mile revision before NEET MDS, INI-CET MDS and INBDE, so you can scan it in minutes instead of re-reading a whole textbook chapter.

ReactionCommon Causative DrugsFeature
Oral lichenoid drug reactionNSAIDs, antihypertensives (ACE inhibitors, beta blockers), antimalarials, gold saltsOften unilateral/asymmetric lesions (vs bilateral, symmetric lesions of idiopathic lichen planus); resolves on drug withdrawal
Drug-induced gingival overgrowthPhenytoin, cyclosporine, nifedipine/calcium channel blockersClassic triad; begins at interdental papilla, worse with poor oral hygiene
Fixed drug eruptionSulfonamides, NSAIDsRecurs at exactly the same site on re-exposure to the drug
AnaphylaxisPenicillin (MC trigger in dental setting), latexType I (IgE-mediated) hypersensitivity; first-line treatment = IM epinephrine 0.3-0.5mg (1:1000) into the anterolateral thigh
AngioedemaACE inhibitors, allergic reactionsLip/tongue/airway swelling - potential emergency
Mnemonic: "PCN" causes drug-induced gingival overgrowth = Phenytoin, Cyclosporine, Nifedipine.
HY: Intramuscular epinephrine (1:1000, anterolateral thigh) is the FIRST-LINE, most critical treatment for anaphylaxis in the dental office - antihistamines and steroids are only adjuncts, not first-line - a frequently tested emergency-management point.
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