Fillers in composite resin are inorganic particles that enhance the mechanical and optical properties of the material. They come in various sizes, shapes, and compositions. The choice of filler influences the resin's strength, wear resistance, and polishability.

Types of fillers:
- Silica: Common in microfilled and hybrid composites, providing good aesthetics and polishability.
- Glass particles: Used in macrofill and microfill composites for high strength and durability.
- Ceramic particles: Provide excellent biocompatibility and wear resistance.
- Zirconia/silica: Combined to improve the strength and translucency of the composite.
- Nanoparticles: Enhance the resin's physical properties, including strength and wear resistance, while also offering improved aesthetics.

Filler size:
- Macrofillers: 10-50 μm, suitable for class I and II restorations where high strength is not essential but a good seal is required.
- Microfillers: 0.01-10 μm, used for fine detailing and aesthetic restorations due to their ability to blend with the tooth structure.
- Hybrid fillers: Combine macro and microfillers for restorations requiring both strength and aesthetics.

Filler loading: The amount of filler in the resin affects the material's physical properties:
- High filler loading: Increases strength, wear resistance, and decreases shrinkage but can compromise the resin's ability to adapt to the tooth structure.
- Low filler loading: Provides better flow and marginal adaptation but may result in lower strength and durability.

Filler-resin interaction:
- Chemical bonding: Improves the adhesion between the filler and the resin matrix.
- Mechanical interlocking: Larger filler particles create a stronger mechanical bond within the resin.
- Polymerization shrinkage: The filler can reduce shrinkage stress, which is crucial for minimizing marginal gaps and microleakage.

Selection criteria:
- Clinical requirements: The filler should meet the specific needs of the restoration, such as strength, wear resistance, and aesthetics.
- Tooth location: Anterior teeth may require more translucent fillers for better aesthetics, while posterior teeth need stronger, more opaque materials.
- Patient's preferences: Some patients may prefer more natural-looking restorations.
- Clinician's skill: Different fillers may require varying application techniques and curing times.