Nystatin and clotrimazole target ergosterol in the fungal cell membrane, leading to increased permeability and death of the fungal cells. This mechanism is specific to fungal cells and does not harm human cells, which lack ergosterol in their membranes.

SOLUTION

The key to success is to use an appliance that is both comfortable, easily retained and predictable such as a simple Hawley retainer with recurve springs or a fixed labial-lingual appliance (including a vertical removable arch for ease of adjustment with a recurve spring to jump the cross-bite). 

Both of these appliances work by tipping the maxillary teeth forward so they are in a normal dental relationship to the mandibular teeth. Once this is accomplished, it will allow future coordinated growth between the maxilla and the mandible

the medium suitable for the transport of Salmonella and Shigella is Cary-Blair mediumx. This medium is designed to maintain the viability of these organisms during transport and is selective for enteric pathogens by inhibiting the growth of other non-target bacteria. TCBS agar and HE agar are used for the selective isolation and growth of these organisms, while blood agar is a general purpose medium used for various bacteria.

Mucostatic materials theoretically do not exert distorting forces on soft tissues during impression taking, which includes impression plaster, agar, light-body elastomers, and certain consistencies of other materials.

Nasal fractures, even minor ones, can lead to bruising (ecchymosis) and swelling (edema) around the nose and face due to the vascularity of the area.

 Most nasal fractures, especially minor ones, do not require reduction (surgical realignment) unless there is significant displacement or functional impairment. Typically, if reduction is necessary, it is done shortly after the injury, not for a few weeks.

Traumatic telecanthus (increased distance between the inner canthi of the eyes) can occur with severe nasal injuries, but it is not a necessary complication of all nasal fractures.

Severe nasal fractures can lead to complications such as the telescoping of the nasal complex, which may involve displacement into adjacent structures, including the frontal sinus.