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Pharmacology

Steroids in Dentistry - Dose, Duration, When to Give?

NEET MDSINI-CET MDSINBDE

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IndicationSteroid & Typical DoseDuration/Note
3rd molar surgery (edema/trismus control)Dexamethasone 4-8mg single dose, IM/IV pre-op or immediately post-op (oral 8mg pre-op also used)Single dose is usually sufficient; significantly reduces postoperative facial swelling and limited mouth opening
Oral lichen planus (erosive/symptomatic)Topical: Triamcinolone acetonide 0.1% or Clobetasol propionate 0.05% ointment applied to lesions 2-3 times daily; Systemic (severe/refractory): short-course oral PrednisoloneTopical is first-line; systemic reserved for widespread/refractory erosive disease, tapered over 2-4 weeks
Recurrent aphthous stomatitis (major/severe)Topical Triamcinolone in Orabase, or a short systemic Prednisolone taper for severe major aphthaeReduces pain and duration of the ulcerative episode
TMJ intra-articular inflammation (refractory synovitis)Intra-articular Triamcinolone or Betamethasone injectionReserved for cases unresponsive to conservative splint/NSAID therapy; repeated injections avoided due to risk of cartilage damage
Adrenal insufficiency / steroid-dependent patients undergoing dental surgerySupplemental "stress dose" steroid cover before invasive procedures, as advised by the treating physicianPrevents an adrenal (Addisonian) crisis under the stress of surgery/infection
General cautionShort courses (a few days, e.g. peri-operative single/short dosing) are generally safeLong-term/chronic systemic steroid use requires tapering (not abrupt stoppage) to avoid adrenal suppression, and carries risks of hyperglycemia, delayed healing, and increased infection susceptibility
Mnemonic: "Single dose BEFORE surgery beats multiple doses AFTER" - pre-emptive dexamethasone given before or immediately after 3rd molar surgery is more effective at limiting the peak inflammatory edema/trismus response than starting steroids once swelling has already begun.
HY: A single pre-operative or immediate post-operative dose of dexamethasone (4-8mg) for 3rd molar surgery is the single most well-evidenced and repeatedly tested steroid indication in dentistry - it works by blocking phospholipase A2, shutting down BOTH the prostaglandin and leukotriene arms of the inflammatory cascade, unlike NSAIDs which block only the COX (prostaglandin) pathway.
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