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NEET MDS Synopsis

Periodontium
Dental Anatomy

The periodontium consists of tissues supporting and investing the tooth and includes cementum, the periodontal ligament (PDL), and alveolar bone.

Parts of the gingiva adjacent to the tooth also give minor support, although the gingiva is Not considered to be part of the periodontium in many texts. For our purposes here, the groups Of gingival fibers related to tooth investment are discussed in this section.

Movements of the Temporomandibular Joint
Anatomy

Movements of the Temporomandibular Joint


The two movements that occur at this joint are anterior gliding and a hinge-like rotation.
When the mandible is depressed during opening of the mouth, the head of the mandible and articular disc move anteriorly on the articular surface until the head lies inferior to the articular tubercle.



As this anterior gliding occurs, the head of the mandible rotates on the inferior surface of the articular disc.
This permits simple chewing or grinding movements over a small range.



Movements that are seen in this joint are: depression, elevation, protrusion, retraction and grinding

Intravenous Anesthetic Agents
Anaesthesia

Intravenous Anesthetic Agents
Intravenous anesthetic agents are crucial in modern anesthesia practice,
providing rapid onset of sedation and analgesia. This lecture will cover the
most commonly used intravenous anesthetic agents, including their indications,
contraindications, and required doses.

1. Benzodiazepines
Overview
Benzodiazepines are primarily used for their anxiolytic (anxiety-reducing)
and amnesic properties. They are frequently used in procedural sedation and as
adjuncts in general anesthesia.
Common Agents


Diazepam

Dose: 5-10 mg IV (may repeat every 5-15 minutes as
needed)
Indications: Anxiety, sedation, muscle relaxation,
seizure control.
Contraindications: Hypersensitivity, severe
respiratory depression, acute narrow-angle glaucoma.



Lorazepam

Dose: 1-4 mg IV (may repeat every 6-8 hours as
needed)
Indications: Anxiety, sedation, preoperative
medication.
Contraindications: Hypersensitivity, severe
respiratory depression, acute narrow-angle glaucoma.



Midazolam

Dose: 1-5 mg IV (may repeat every 2-5 minutes as
needed)
Indications: Procedural sedation, induction of
anesthesia, anxiety reduction.
Contraindications: Hypersensitivity, severe
respiratory depression, acute narrow-angle glaucoma.




2. Etomidate
Overview
Etomidate is an imidazole derivative used for rapid intravenous induction of
anesthesia. It is known for its minimal cardiovascular effects.
Dose

Dose: 0.2-0.3 mg/kg IV (administered over 30-60
seconds)

Indications

Induction of anesthesia, particularly in patients with cardiovascular
instability.

Contraindications

Hypersensitivity to etomidate, adrenal insufficiency (due to suppression
of adrenal function).


3. Ketamine
Overview
Ketamine is a unique intravenous anesthetic that provides dissociative
anesthesia and analgesia. It is known for its ability to increase cerebral blood
flow.
Dose

Dose: 1-2 mg/kg IV (for induction)

Indications

Induction of anesthesia, analgesia for painful procedures, and in
patients with asthma or reactive airway disease.

Contraindications

Hypersensitivity, severe hypertension, or increased intracranial
pressure.

Additional Notes

Ketamine may offer neuroprotective effects and is often used in
pediatric patients due to its safety profile.


4. Barbiturates
Overview
Barbiturates are central nervous system depressants that have been used for
induction of anesthesia. They act primarily at the GABA receptor.
Common Agents


Thiopental

Dose: 3-5 mg/kg IV (for induction)



Methohexital

Dose: 1-2 mg/kg IV (for induction)



Thiamylal

Dose: 3-5 mg/kg IV (for induction)



Indications

Induction of anesthesia, sedation, and as anticonvulsants.

Contraindications

Hypersensitivity, porphyria, severe respiratory depression.


5. Propofol
Overview
Propofol is an alkylated phenol that provides rapid sedation and is widely
used for induction and maintenance of anesthesia.
Dose

Dose: 1-2.5 mg/kg IV (for induction)

Indications

Induction and maintenance of anesthesia, sedation for procedures.

Contraindications

Hypersensitivity to propofol or its components, egg or soy allergy.

Additional Notes

Propofol is favored for outpatient procedures due to its rapid recovery
profile and low incidence of nausea and vomiting.


6. Opioid Analgesics
Overview
Opioids are potent analgesics that act centrally on μ-receptors in the brain
and spinal cord. They are often used in conjunction with other anesthetic
agents.
Common Agents


Meperidine

Dose: 25-100 mg IV (for analgesia)



Fentanyl-based compounds

Dose: 25-100 mcg IV (for analgesia)



Morphine

Dose: 2-10 mg IV (for analgesia)



Codeine

Dose: 15-60 mg IV (for analgesia)



Oxymorphone

Dose: 1-5 mg IV (for analgesia)



Indications

Pain management, adjunct to anesthesia.

Contraindications

Hypersensitivity, respiratory depression, severe asthma, or head injury.

Additional Notes

Opioids have differing potencies, and equianalgesic doses can result in
similar degrees of respiratory depression. Therefore, there is no completely
safe opioid analgesic.

Rheumatoid Arthritis
Orthopaedics

- The hallmark feature of rheumatoid arthritis is persistent symmetric polyarthritis (synovitis) of hands and feet.
- The spontaneous onset of excruciating pain, edema, and inflammation in the metatarsalphalangeal joint of the great toe (podagra) is highly suggestive of acute crystal-induced arthritis.
- Podagra is the initial joint manifestation in 50% of gout cases and is eventually involved in 90%.

- RA is a chronic autoimmune multisystem disease having inflammatory arthritis and systemic manifestation.
 
Pathogenesis –
1.    Women (30 to 50 years) are more commonly affected
2.    HLA-DR 4 Q is a risk factor for RA.
3.    Initial site of disease is synovial membrane
Initiation phase – It is due to non – specific inflammation
 
Amplification phase – Due to T cell activation
 
Chronic inflammatory phase – Due to cytokines IL – 1, TNF- alpha (AIPG 2009) and IL – 6
 
Diagnostic criteria
Four of seven criteria are required
1.    Morning stiffness – lasting 1 hour before maximal improvement
2.    Arthritis of 3 or more joint areas – 14 possible joint areas are right or left PIP MCP, wrist, elbow, knee, ankle and MTP joints
3.    Arthritis of hand joints.
4.    Symmetrical arthritis.
5.    Rheumatoid nodules.
6.    Positive Serum rheumatoid factor
7.    Radiographic changes – including erosions or unequivocal bong decalcification localized in or most marked adjacent to the involved joint.

Functional Matrix Hypothesis
Orthodontics

Functional Matrix Hypothesis is a concept in orthodontics
and craniofacial biology that explains how the growth and development of the
craniofacial complex (including the skull, face, and dental structures) are
influenced by functional demands and environmental factors rather than solely by
genetic factors. This hypothesis was proposed by Dr. Robert A. K.
McNamara and is based on the idea that the functional matrices—such as
muscles, soft tissues, and functional activities (like chewing and
speaking)—play a crucial role in shaping the skeletal structures.
Concepts of the Functional Matrix Hypothesis


Functional Matrices:

The hypothesis posits that the growth of the craniofacial skeleton
is guided by the functional matrices surrounding it. These matrices
include:
Muscles: The muscles of mastication, facial
expression, and other soft tissues exert forces on the bones,
influencing their growth and development.
Soft Tissues: The presence and tension of soft
tissues, such as the lips, cheeks, and tongue, can affect the
position and growth of the underlying skeletal structures.
Functional Activities: Activities such as
chewing, swallowing, and speaking create functional demands that
influence the growth patterns of the craniofacial complex.





Growth and Development:

According to the Functional Matrix Hypothesis, the growth of the
craniofacial skeleton is not a direct result of genetic programming but
is instead a response to the functional demands placed on it. This means
that changes in function can lead to changes in growth patterns.
For example, if a child has a habit of mouth breathing, the lack of
proper nasal function can lead to altered growth of the maxilla and
mandible, resulting in malocclusion or other dental issues.



Orthodontic Implications:

The Functional Matrix Hypothesis has significant implications for
orthodontic treatment and craniofacial orthopedics. It suggests that:
Functional Appliances: Orthodontic appliances
that modify function (such as functional appliances) can be used to
influence the growth of the jaws and improve occlusion.
Early Intervention: Early orthodontic
intervention may be beneficial in guiding the growth of the
craniofacial complex, especially in children, to prevent or correct
malocclusions.
Holistic Approach: Treatment should consider
not only the teeth and jaws but also the surrounding soft tissues
and functional activities.





Clinical Applications:

The Functional Matrix Hypothesis encourages clinicians to assess the
functional aspects of a patient's oral and facial structures when
planning treatment. This includes evaluating muscle function, soft
tissue relationships, and the impact of habits (such as thumb sucking or
mouth breathing) on growth and development.



Impression Materials -Applications 
Dental Materials

Applications

a. Dentulous impressions for casts for prosthodontics

b. Dentulous impressions for pedodontic appliances

c. Dentulous impressions for study models for orthodontics

d. Edentulous impressions for casts for denture construction

Miconazole
Pharmacology

Miconazole

Miconazole is an  imidazole antifungal agent commonly used in topical sprays, creams and ointments applied to the  skin to cure fungal infections such as Athlete's foot and Jock itch. It may also be used internally to treat vaginal  yeast infection.

When used by a person taking the anticoagulant medication warfarin, Miconazole may cause an adverse reaction which can lead to excessive bleeding or bruising.

Gow-Gates Technique for Mandibular Anesthesia
Oral and Maxillofacial Surgery

Gow-Gates Technique for Mandibular Anesthesia
The Gow-Gates technique is a well-established method for
achieving effective anesthesia of the mandibular teeth and associated soft
tissues. Developed by George Albert Edwards Gow-Gates, this technique is known
for its high success rate in providing sensory anesthesia to the entire
distribution of the mandibular nerve (V3).
Overview

Challenges in Mandibular Anesthesia: Achieving
successful anesthesia in the mandible is often more difficult than in the
maxilla due to:
Greater anatomical variation in the mandible.
The need for deeper penetration of soft tissues.


Success Rate: Gow-Gates reported an astonishing success
rate of approximately 99% in his experienced hands, making
it a reliable choice for dental practitioners.

Anesthesia Coverage
The Gow-Gates technique provides sensory anesthesia to the following nerves:

Inferior Alveolar Nerve
Lingual Nerve
Mylohyoid Nerve
Mental Nerve
Incisive Nerve
Auriculotemporal Nerve
Buccal Nerve

This comprehensive coverage makes it particularly useful for procedures
involving multiple mandibular teeth.
Technique
Equipment

Needle: A 25- or 27-gauge long needle is
recommended for this technique.

Injection Site and Target Area


Area of Insertion:

The injection is performed on the mucous membrane on
the mesial aspect of the mandibular ramus.
The insertion point is located on a line drawn from the intertragic
notch to the corner of the mouth, just distal
to the maxillary second molar.



Target Area:

The target for the injection is the lateral side of the
condylar neck, just below the insertion of the lateral
pterygoid muscle.



Landmarks
Extraoral Landmarks:

Lower Border of the Tragus: This serves as a reference
point. The center of the external auditory meatus is the ideal landmark, but
since it is concealed by the tragus, the lower border is used as a visual
aid.
Corner of the Mouth: This helps in aligning the
injection site.

Intraoral Landmarks:

Height of Injection: The needle tip should be placed
just below the mesiopalatal cusp of the maxillary second
molar to establish the correct height for the injection.
Penetration Point: The needle should penetrate the soft
tissues just distal to the maxillary second molar at the height established
in the previous step.

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