NEET MDS Synopsis
Nalidixic acid
Pharmacology
Nalidixic acid:
Nalidixic acid is the basis for quinolone antibiotics. It acts bacteriostatically (that is, it inhibits growth and reproduction) or bactericidally (it kills them) on both Gram positive and Gram negative bacteria, depending on the concentration. It is especially used in treating urinary tract infections, caused for example by Escherichia coli, Proteus, Enterobacter and Klebsiella.
Stages of Development
PedodonticsStages of Development
Sensorimotor Stage (0-2 years):
Overview: In this stage, infants learn about the
world primarily through their senses and motor activities. They begin to
interact with their environment and develop basic cognitive skills.
Key Characteristics:
Object Permanence: Understanding that objects
continue to exist even when they cannot be seen.
Exploration: Infants engage in play by
manipulating objects, which helps them learn about cause and effect.
Symbolic Play: Even at this early stage,
children may begin to engage in simple forms of symbolic play, such
as pretending a block is a car.
Example in Dental Context: A child may play with
toys while sitting in the dental chair, exploring their environment and
becoming familiar with the setting.
Pre-operational Stage (2-6 years):
Overview: During this stage, children begin to use
language and engage in symbolic play, but their thinking is still
intuitive and egocentric. They struggle with understanding the
perspectives of others.
Key Characteristics:
Animism: The belief that inanimate objects have
feelings and intentions (e.g., thinking a toy can feel sad).
Constructivism: Children actively construct
their understanding of the world through experiences and
interactions.
Symbolic Play: Children engage in imaginative
play, using objects to represent other things (e.g., using a stick
as a sword).
Example: A child might pretend that a stuffed
animal is talking or has feelings, demonstrating animism.
Concrete Operational Stage (6-12 years):
Overview: In this stage, children begin to think
logically about concrete events. They can perform operations and
understand the concept of conservation (the idea that quantity doesn’t
change even when its shape does).
Key Characteristics:
Ego-centrism: While children in this stage are
less egocentric than in the pre-operational stage, they may still
struggle to see things from perspectives other than their own.
Logical Thinking: Children can organize objects
into categories and understand relationships between them.
Conservation: Understanding that certain
properties (like volume or mass) remain the same despite changes in
form or appearance.
Example: A child may understand that pouring water
from a short, wide glass into a tall, narrow glass does not change the
amount of water.
Formal Operational Stage (11-15 years):
Overview: In this final stage, adolescents develop
the ability to think abstractly, reason logically, and use deductive
reasoning. They can consider hypothetical situations and think about
possibilities.
Key Characteristics:
Abstract Thinking: Ability to think about
concepts that are not directly tied to concrete objects (e.g.,
justice, freedom).
Hypothetical-Deductive Reasoning: Ability to
formulate hypotheses and systematically test them.
Metacognition: Awareness and understanding of
one’s own thought processes.
Example: An adolescent can discuss moral dilemmas
or scientific theories, considering various outcomes and implications.
The Nasal Mucosa
AnatomyThe Nasal Mucosa
Mucosa lines the entire nasal cavities except for the vestibule of the nose.
The nasal mucosa is firmly bound to the periosteum and perichondrium of the supporting structures of the nose.
It is continuous with the adjoining cavities to which the nasal cavity communicates (e.g., the nasopharynx and paranasal sinuses).
The inferior 2/3 of the nasal mucosa is called the respiratory area and air passing over this is warmed and moistened before it passes into the lungs.
The superior 1/3 is called the olfactory area.
The Olfactory Area of Nasal Mucosa
This area contains the peripheral organ of smell.
Sniffing draws air into this area
Olfactory receptor cells (from the olfactory nerve, CN I, are located in the mucosa of this area in the nose.
Nerves to the Respiratory Area of Nasal Mucosa
The inferior 2/3 of the nasal mucosa are supplied chiefly by the trigeminal nerve (CN V).
The mucous membrane of the nasal septum is supplied chiefly by the nasopalatine nerve, a branch of the maxillary nerve (CN V2).
Its anterior portion is supplied by the anterior ethmoidal nerve (a branch of the nasociliary nerve) which is derived from the ophthalmic nerve (CN V1).
The lateral walls of the nasal cavity are supplied by branches of the maxillary nerve (CN V2); the greater palatine nerve, and the anterior ethmoidal nerve.
Arteries of the Nasal Mucosa
The blood supply of the mucosa of the nasal septum is derived mainly from the maxillary artery.
The sphenopalatine artery, a branch of the maxillary, supplies most of the blood of the nasal mucosa.
It enters by the sphenopalatine foramen and sends branches to the posterior regions of the lateral wall and to the nasal septum.
The greater palatine artery, also a branch of the maxillary, passes through the incisive foramen to supply the nasal septum.
The anterior and posterior ethmoidal arteries, branches of the ophthalmic artery, supply the anterosuperior part of the mucosa of the lateral wall of the nasal cavity and nasal septum.
Three branches of the facial artery (superior labial, ascending palatine, and lateral nasal) also supply the anterior parts of the nasal mucosa.
Veins of the Nasal Mucosa
The veins of the nasal mucosa form a venous network of plexus in the connective tissue of the nasal mucosa.
Some of the veins open into the sphenopalatine vein and drain to the pterygoid plexus.
Others join the facial and infraorbital veins.
Some empty into the ophthalmic veins and drain into the cavernous sinus.
Sympatholytics - Antiadrenergic Agents
Pharmacology
Sympatholytics (Antiadrenergic Agents)
PHENOXYBENZAMINE
It is a potent alpha-adrenergic blocking agent
It effectively prevents the responses mediated by alpha receptors and diastolic blood pressure tends to decrease.
It interferes with the reflex adjustment of blood pressure and produces postural hypotension.
It increases the cardiac output and decreases the total peripheral resistance.
It is used in the management of pheochromocytoma and also to treat peripheral vasospastic conditions e.g. Raynaud’s disease and shock syndrome.
Phentolamine, another alpha blocker is exclusively used for the diagnosis of pheochromocytoma and for the prevention of abrupt rise in blood pressure during surgical removal of adrenal medulla tumors.
ERGOT ALKALOIDS
Ergotamine is an important alkaloid that possesses both vasoconstrictor and alpha-receptor blocking activity. Both ergotamine and dihydroergotamine are used in the treatment of migraine.
METHYSERGIDE
It is a 5-hydroxytryptamine antagonist ). It is effective in preventing an attack of migraine.
SUMATRIPTAN
It is a potent selective 5-HT 1D receptor agonist used in the treatment of migraine.
PRAZOSIN
It is an piperazinyl quinazoline effective in the management of hypertension. It is highly selective for α1 receptors. It also reduces the venous return and cardiac output. It is used in essential hypertension, benign prostatic hypertrophy and in Raynaud’s syndrome.
Prazosin lowers blood pressure in human beings by relaxing both veins and resistance vessels but it dilates arterioles more than veins.
TERAZOSIN
It is similar to prazosin but has higher bioavailability and longer plasma t½
DOXAZOSIN
It is another potent and selective α1 adrenoceptor antagonist and quinazoline derivative.
It’s antihypertensive effect is produced by a reduction in smooth muscle tone of peripheral vascular beds.
TAMSULOSIN
It is uroselective α1A blocker and has been found effective in improving BPH symptoms.
Other drugs used for erectile dysfunction
Sildenafil: It is orally active selective inhibitor of phosphodiesterase type 5 useful in treatment of erectile dysfunction.
Mental Age Assessment
PedodonticsMental Age Assessment
Mental age can be assessed using the following formula:
Mental Age = (Chronological Age × 100) / 10
Mental Age Descriptions
Below 69: Mentally retarded (intellectual disability).
Below 90: Low average intelligence.
90-110: Average intelligence. Most children fall within
this range.
Above 110: High average or superior intelligence.
Neural Substrates of Breathing
PhysiologyNeural Substrates of Breathing
A. Medulla Respiratory Centers
Inspiratory Center (Dorsal Resp Group - rhythmic breathing) → phrenic nerve→ intercostal nerves→ diaphragm + external intercostals
Expiratory Center (Ventral Resp Group - forced expiration) → phrenic nerve → intercostal nerves → internal intercostals + abdominals (expiration)
1. eupnea - normal resting breath rate (12/minute)
2. drug overdose - causes suppression of Inspiratory Center
B. Pons Respiratory Centers
1. pneumotaxic center - slightly inhibits medulla, causes shorter, shallower, quicker breaths
2. apneustic center - stimulates the medulla, causes longer, deeper, slower breaths
C. Control of Breathing Rate & Depth
1. breathing rate - stimulation/inhibition of medulla
2. breathing depth - activation of inspiration muscles
3. Hering-Breuer Reflex - stretch of visceral pleura that lungs have expanded (vagal nerve)
D. Hypothalamic Control - emotion + pain to the medulla
E. Cortex Controls (Voluntary Breathing) - can override medulla as during singing and talking
Steiner's Analysis
OrthodonticsSteiner's Analysis
Steiner's analysis is a widely recognized cephalometric method used in
orthodontics to evaluate the relationships between the skeletal and dental
structures of the face. Developed by Dr. Charles A. Steiner in the 1950s, this
analysis provides a systematic approach to assess craniofacial morphology and is
particularly useful for treatment planning and evaluating the effects of
orthodontic treatment.
Key Features of Steiner's Analysis
Reference Planes and Points:
Sella (S): The midpoint of the sella turcica, a
bony structure in the skull.
Nasion (N): The junction of the frontal and nasal
bones.
A Point (A): The deepest point on the maxillary
arch between the anterior nasal spine and the maxillary alveolar
process.
B Point (B): The deepest point on the mandibular
arch between the anterior nasal spine and the mandibular alveolar
process.
Menton (Me): The lowest point on the symphysis of
the mandible.
Gnathion (Gn): The midpoint between Menton and
Pogonion (the most anterior point on the chin).
Pogonion (Pog): The most anterior point on the
contour of the chin.
Reference Lines:
SN Plane: A line drawn from Sella to Nasion,
representing the cranial base.
ANB Angle: The angle formed between the lines
connecting A Point to Nasion and B Point to Nasion. It indicates the
relationship between the maxilla and mandible.
Facial Plane (FP): A line drawn from Gonion (Go) to
Menton (Me), used to assess the facial profile.
Key Measurements:
ANB Angle: Indicates the anteroposterior
relationship between the maxilla and mandible.
Normal Range: Typically between 2° and 4°.
SN-MP Angle: The angle between the SN plane and the
mandibular plane (MP), which helps assess the vertical position of the
mandible.
Normal Range: Usually between 32° and 38°.
Wits Appraisal: The distance between the
perpendiculars dropped from points A and B to the occlusal plane. It
provides insight into the anteroposterior relationship of the dental
bases.
Clinical Relevance
Diagnosis and Treatment Planning: Steiner's analysis
helps orthodontists diagnose skeletal discrepancies and plan appropriate
treatment strategies. It provides a clear understanding of the patient's
craniofacial relationships, which is essential for effective orthodontic
intervention.
Monitoring Treatment Progress: By comparing
pre-treatment and post-treatment cephalometric measurements, orthodontists
can evaluate the effectiveness of the treatment and make necessary
adjustments.
Predicting Treatment Outcomes: The analysis aids in
predicting the outcomes of orthodontic treatment by assessing the initial
skeletal and dental relationships.
General chromosome abnormalities
General Pathology
General chromosome abnormalities
The normal human cell contains 46 chromosomes, including 22 homologous pairs of autosomes and one pair of sex chromosomes (XX for female and XY for male). A somatic cell is diploid, containing 46 chromosomes. Gametes are haploid, containing 23 chromosomes.
Aneuploidy
(a) Any deviation in the number of chromosomes, whether fewer or more, from the normal haploid number of chromosomes.
(b) Nondisjunction—a common cause of aneuploidy. It is the failure of chromosomes to pass to separate cells during meiotic or mitotic cell division.
(c) Often seen in malignant tumors.
Deletion: loss of a sequence of DNA from a chromosome.
Translocation: the separation of a chromosome and the attachment of the area of separation to another chromosome.