NEET MDS Synopsis
Tubular reabsorption
Physiology
Remember the following principles before proceeding :
- Reabsorption occurs for most of substances that have been previously filterd .
- The direction of reabsorption is from the tubules to the peritubular capillaries
- All of transport mechanism are used here.
- Different morphology of the cells of different parts of the tubules contribute to reabsorption of different substances .
- There are two routes of reabsorption: Paracellular and transcellular : Paracellular reabsorption depends on the tightness of the tight junction which varies from regeon to region in the nephrons .Transcellular depends on presence of transporters ( carriers and channels for example).
1. Reabsorption of glucose , amino acids , and proteins :
Transport of glucose occurs in the proximal tubule . Cells of proximal tubules are similar to those of the intestinal mucosa as the apical membrane has brush border form to increase the surface area for reabsorption , the cells have plenty of mitochondria which inform us that high amount of energy is required for active transport , and the basolateral membrane of the cells contain sodium -potassium pumps , while the apical membrane contains a lot of carrier and channels .
The tight junction between the tubular cells of the proximal tubules are not that (tight) which allow paracellular transport.
Reabsorption of glucose starts by active transport of Na by the pumps on the basolateral membrane . This will create Na gradient which will cause Na to pass the apical membrane down its concentration gradient . Glucose also passes the membrane up its concentration gradient using sodium -glucose symporter as a secondary active transport.
The concentration of glucose will be increased in the cell and this will enable the glucose to pass down concentration gradient to the interstitium by glucose uniporter . Glucose will then pass to the peritubular capillaries by simple bulk flow.
Remember: Glucose reabsorption occurs via transcellular route .
Glucose transport has transport maximum . In normal situation there is no glucose in the urine , but in uncontrolled diabetes mellitus patients glucose level exceeds its transport maximum (390 mg/dl) and thus will appear in urine .
2. Reabsorption of Amino acids : Use secondary active transport mechanism like glucose.
3. Reabsorption of proteins :
Plasma proteins are not filtered in Bowman capsule but some proteins and peptides in blood may pass the filtration membrane and then reabsorbed . Some peptides are reabsorbed paracellulary , while the others bind to the apical membrane and then enter the cells by endocytosis , where they will degraded by peptidase enzymes to amino acids .
4. Reabsorption of sodium , water , and chloride:
65 % of sodium is reabsorbed in the proximal tubules , while 25% are reabsorbed in the thick ascending limb of loob of Henle , 9% in the distal and collecting tubules and collecting ducts .
90% of sodium reabsorption occurs independently from its plasma level (unregulated) , This is true for sodium reabsorbed in proximal tubule and loop of Henle , while the 9% that is reabsorbed in distal ,collecting tubules and collecting ducts is regulated by Aldosterone.
In proximal tubules : 65% of sodium is reabsorbed . The initial step occurs by creating sodium gradient by sodium-potassium pump on the basolateral membrane . then the sodium will pass from the lumen into the cells down concentration gradient by sodium -glucose symporter , sodium -phosphate symporter and by sodium- hydrogen antiporter and others
After reabsorption of sodium , an electrical gradient will be created , then chloride is reabsorbed following the sodium . Thus the major cation and anion leave the lumen to the the interstitium and thus the water follows by osmosis . 65% of water is reabsorbed in the proximal tubule.
Discending limb of loop of Henle is impermeable to electrolytes but avidly permeable to water . 10 % of water is reabsorbed in the discending thin limb of loob of Henle .
The thick ascending limb of loop of Henly is permeable to electrolytes , due to the presence of Na2ClK syporter . 25% of sodium is reabsorbed here .
In the distal and collecting tubules and the collecting ducts 9% of sodium is reabsorbed .this occurs under aldosterone control depending on sodium plasma level. 1% of sodium is excreted .
Water is not reabsorbed from distal tubule but 5-25% of water is reabsorbed in collecting tubules .
STEROIDS
Biochemistry
STEROIDS
Steroids are the compounds containing a cyclic steroid nucleus (or ring) namely cyclopentanoperhydrophenanthrene (CPPP).It consists of a phenanthrene nucleus (rings A, B and C) to which a cyclopentane ring (D) is attached.
Steroids are the compounds containing a cyclic steroid nucleus (or ring) namely cyclopentanoperhydrophenanthrene (CPPP).It consists of a phenanthrene nucleus (rings A, B and C) to which a cyclopentane ring (D) is attached.
There are several steroids in the biological system. These include cholesterol, bile acids, vitamin D, sex hormones, adrenocortical hormones,sitosterols, cardiac glycosides and alkaloids
Acid-Peptic disorders
Pharmacology
Acid-Peptic disorders
This group of diseases include peptic ulcer, gastroesophageal reflux and Zollinger-Ellison syndrome.
Pathophysiology of acid-peptic disorders
Peptic ulcer disease is thought to result from an imbalance between cell– destructive effects of hydrochloric acid and pepsin on the one side, and cell-protective effects of mucus and bicarbonate on the other side. Pepsin is a proteolytic enzyme activated in gastric acid (above pH of 4, pepsin is inactive); also it can digest the stomach wall. A bacterium, Helicobacter pylori, is now accepted to be involved in the pathogenesis of peptic ulcer.
In gastroesophageal reflux the acidic contents of the stomach enter into the oesophagus causing a burning sensation in the region of the heart; hence the common name heartburn or other names such as indigestion and dyspepsia.
However, Zollinger-Ellison syndrome is caused by a tumor of gastrin secreting cells of the pancreas characterized by excessive secretion of gastrin that stimulates gastric acid secretion.
These disorders can be treated by the following classes of drugs:
A. Gastric acid neutralizers (antacids)
B. Gastric acid secretion inhibitors (antisecretory drugs)
C. Mucosal protective agents
D. Drugs that exert antimicrobial action against H.pylori
Exchange of gases in Lungs
PhysiologyExchange of gases takes place in Lungs
A person with an average ventilation rate of 7.5 L/min will breathe in and out 10,800 liters of gas each day
From this gas the person will take in about 420 liters of oxygen (19 moles/day) and will give out about 340 liters of carbon dioxide (15 moles/day)
The ratio of CO2 expired/O2 inspired is called the respiratory quotient (RQ)
RQ = CO2 out/O2 in = 340/420 = 0.81
In cellular respiration of glucose CO2 out = O2 in; RQ = 1
The overall RQ is less than 1 because our diet is a mixture of carbohydrates and fat; the RQ for metabolizing fat is only 0.7
All of the exchange of gas takes place in the lungs
The lungs also give off large amounts of heat and water vapor
Parkinson’s disease
General Pathology
Parkinson’s disease
a. Characterized by the degeneration of neurons in the basal ganglia, specifically the substantia nigra and striatum.
b. Histologic findings in affected neurons include Lewy bodies.
c. Clinically, the disease affects involuntary and voluntary movements. Tremors are common. Symptoms include pin-rolling tremors, slowness of movements, muscular rigidity, and shuffling gait.
Cerebral palsy and Treatment
PedodonticsCerebral palsy (CP) is a neurological disorder resulting from damage to the
brain during its development before, during, or shortly after birth. This
condition is non-progressive, meaning that it does not worsen over time, but it
manifests as a range of neurological problems that can significantly impact a
child's mobility, muscle control, and posture.
Causes:
The primary cause of CP is any factor that leads to decreased oxygen supply
(hypoxia) to the developing brain. This can occur due to various reasons,
including complications during pregnancy, childbirth, or immediately after
birth.
Classification of Cerebral Palsy:
Based on Anatomical Involvement:
Monoplegia: One limb is affected.
Hemiplegia: One side of the body is affected.
Paraplegia: Both legs are affected.
Quadriplegia: All four limbs are affected.
Based on Neuromuscular Involvement:
Spasticity: Characterized by stiff and tight muscles; this
is the most common type, seen in 70% of cases. Affected individuals may
have limited head movement and a limp gait.
Athetosis: Involves involuntary, writhing movements, seen in
15% of cases. Symptoms include excessive head movement and drooling.
Ataxia: Affects balance and coordination, seen in 5% of
cases. Individuals may exhibit a staggering gait and slow tremor-like
movements.
Mixed: A combination of more than one type of cerebral
palsy, seen in about 10% of cases.
1. Spastic Cerebral Palsy (70% of cases)
Characteristics:
Limited Head Movement: Individuals have restrictions in moving their
head due to increased muscle tone.
Involvement of Cerebral Cortex: Indicates that the motor control areas
of the brain (especially those concerning voluntary movement) are affected.
Limping Gait with Circumduction of the Affected Leg: When walking, the
patient often swings the affected leg around instead of lifting it normally,
due to spasticity.
Hypertonicity of Facial Muscles: Increased muscle tension in the facial
region, contributing to a fixed or tense facial expression.
Unilateral or Bilateral Manifestations: Symptoms can occur on one side
of the body (hemiplegia) or affect both sides (diplegia or quadriplegia).
Slow Jaw Movement: Reduced speed in moving the jaw, potentially leading
to functional difficulties.
Hypertonic Orbicularis Oris Muscles: Increased muscle tone around the
mouth, affecting lip closure and movement.
Mouth Breathing (75%): The individual may breathe through their mouth
due to poor control of oral musculature.
Spastic Tongue Thrust: The tongue pushes forward excessively, which can
disrupt swallowing and speech.
Class II Division II Malocclusion (75%): Dental alignment issue often
characterized by a deep overbite and anterior teeth that are retroclined,
sometimes accompanied by a unilateral crossbite.
Speech Involvement: Difficulties with speech articulation due to muscle
coordination problems.
Constricted Mandibular Arch: The lower jaw may have a narrower
configuration, complicating dental alignment and oral function.
2. Athetoid Cerebral Palsy (15% of cases)
Characteristics:
Excessive Head Movement: Involuntary, uncontrolled movements lead to
difficulties maintaining a stable head position.
Involvement of Basal Ganglia: Damage to this area affects muscle tone
and coordination, leading to issues like chorea (involuntary movements).
Bull Neck Appearance: The neck may appear thicker and less defined,
owing to abnormal muscle development or tone.
Lack of Head Balance, Drawn Back: The head may be held in a retracted
position, affecting posture and balance.
Quick Jaw Movement: Involuntary rapid movements can lead to difficulty
with oral control.
Hypotonic Orbicularis Oris Muscles: Reduced muscle tone around the mouth
can lead to drooling and lack of control of oral secretions.
Grimacing and Drooling: Facial expressions may be exaggerated or
inappropriate due to muscle tone issues, and there may be problems with
managing saliva.
Continuous Mouth Breathing: Patients may consistently breathe through
their mouths rather than their noses.
Tissue Biting: Increased risk of self-biting due to lack of muscle
control.
Tongue Protruding: The tongue may frequently stick out, complicating
speech and intake of food.
High and Narrow Palatal Vault: Changes in the oral cavity structures can
lead to functional difficulties.
Class II Division I Malocclusion (90%): Characterized by a deep bite and
anterior open bite.
Speech Involvement: Affected due to uncontrolled muscle movements.
Muscle of Deglutition Involvement: Difficulties with swallowing due to
affected muscles.
Bruxism: Involuntary grinding or clenching of teeth.
Auditory Organs May be Involved: Hearing impairments can coexist.
3. Ataxic Cerebral Palsy (5% of cases)
Characteristics:
Slow Tremor-like Head Movement: Unsteady, gradual movements of the head,
indicative of coordination issues.
Involvement of Cerebellum: The cerebellum, which regulates balance and
motor control, is impacted.
Lack of Balance Leading to Staggering Gait: Individuals may have
difficulty maintaining equilibrium, leading to a wide-based and unsteady
gait.
Hypotonic Orbicularis Oris Muscles: Reduced muscle tone leading to
difficulties with oral closure and control.
Slow Jaw Movement: The jaw may move slower, affecting chewing and
speech.
Speech Involvement: Communication may be affected due to poor
coordination of the speech muscles.
Visual Organ May be Involved (Nystagmus): Involuntary eye movements may
occur, affecting visual stability.
Varied Type of Malocclusion: Dental alignment issues can vary widely in
this population.
4. Mixed:
Mixed cerebral palsy involves a combination of the above types, where the
individual may exhibit spasticity, athetosis, and ataxia to varying degrees.
Dental Considerations for Mixed CP:
- Dental care for patients with mixed CP is highly individualized and depends on
the specific combination and severity of symptoms.
- The dentist must consider the unique challenges that arise from the
combination of muscle tone issues, coordination problems, and potential for
involvement of facial muscles.
- A multidisciplinary approach, including occupational therapy and speech
therapy, may be necessary to address oral function and hygiene.
- The use of sedation or general anesthesia might be considered for extensive
dental treatments due to the difficulty in managing the patient's movements and
ensuring safety during procedures.
Associated Symptoms:
Children with CP may exhibit persistent reflexes such as the asymmetric tonic
neck reflex, which can influence their dental treatment. Other symptoms may
include mental retardation, seizure disorders, speech difficulties, and joint
contractures.
Dental Problems:
Children with cerebral palsy often experience specific dental challenges:
They may have a higher incidence of dental caries (tooth decay) due to
difficulty in maintaining oral hygiene and dietary preferences.
There is a greater likelihood of periodontal disease, often exacerbated
by medications like phenytoin, which can lead to gum overgrowth and dental
issues.
Dental Treatment Considerations:
When managing dental care for children with cerebral palsy, dentists need to
consider:
Patient Stability: The child’s head should be stabilized, and their back
should be elevated to minimize swallowing difficulties.
Physical Restraints: These can help manage uncontrolled movements during
treatment.
Use of Mouth Props and Finger Splints: These tools can assist in
controlling involuntary jaw movements.
Gentle Handling: Avoid abrupt movements to prevent triggering the
startle reflex.
Local Anesthesia (LA): Administered with caution, ensuring stabilization
to prevent sudden movements.
Premedication: Medications may be given to alleviate muscle
hypertonicity, manage anxiety, and reduce involuntary movements.
General Anesthesia (GA): Reserved for cases that are too challenging to
manage with other methods.
Hormones of the Hypothalamus
Physiology
The hypothalamus is a region of the brain. It secretes a number of hormones.
Thyrotropin-releasing hormone (TRH)
Gonadotropin-releasing hormone (GnRH)
Growth hormone-releasing hormone (GHRH)
Corticotropin-releasing hormone (CRH)
Somatostatin
Dopamine
All of these are released into the blood, travel immediately to the anterior lobe of the pituitary, where they exert their effects.
Two other hypothalamic hormones:
Antidiuretic hormone (ADH) and
Oxytocin
travel in neurons to the posterior lobe of the pituitary where they are released into the circulation.
The Lips
AnatomyThe Lips
These are mobile muscular folds that surround the mouth, the entrance of the oral cavity.
The lips (L. labia) are covered externally by skin and internally by mucous membrane.
In between these are layers of muscles, especially the orbicularis oris muscle.
The upper and lower lips are attached to the gingivae in the median plane by raised folds of mucous membrane, called the labial frenula.
Sensory Nerves of the Lips
The sensory nerves of the upper and lower lips are from the infraorbital and mental nerves, which are branches of the maxillary (CN V2) and mandibular (CN V3) nerves.