Talk to us?

NEETMDS- courses, NBDE, ADC, NDEB, ORE, SDLE-Eduinfy.com

NEET MDS Synopsis

Osmotic diuretics
Pharmacology

Aquaretics
An aquaretic is a class of drug that is used to promote aquaresis, the excretion of water without electrolyte loss.

Lithium, demeclocycline

Mechanism of Action

1.    Block ADH action on distal tubule and collecting duct. Blocking ADH decreases H2O permeability. H2O is not recovered (distal tubule) using osmotic draw of counter-current multiplier so aquaretics reduce water reabsorption (tubule to blood stream). 
2.    Net effect is an increase in free water clearance
 

Pit and Fissure Sealants
Pedodontics

Pit and Fissure Sealants
Pit and fissure sealants are preventive dental materials used to protect
occlusal surfaces of teeth from caries by sealing the grooves and pits that are
difficult to clean. According to Mitchell and Gordon (1990), sealants can be
classified based on several criteria, including polymerization methods, resin
systems, filler content, and color.

Classification of Pit and Fissure Sealants
1. Polymerization Methods
Sealants can be differentiated based on how they harden or polymerize:


a) Self-Activation (Mixing Two Components)

These sealants harden through a chemical reaction that occurs when
two components are mixed together. This method does not require any
external light source.



b) Light Activation

Sealants that require a light source to initiate the polymerization
process can be further categorized into generations:
First Generation: Ultraviolet Light
Utilizes UV light for curing, which can be less common due
to safety concerns.


Second Generation: Self-Cure
These sealants harden through a chemical reaction without
the need for light, similar to self-activating sealants.


Third Generation: Visible Light
Cured using visible light, which is more user-friendly and
safer than UV light.


Fourth Generation: Fluoride-Releasing
These sealants not only provide a physical barrier but also
release fluoride, which can help in remineralizing enamel and
providing additional protection against caries.







2. Resin System
The type of resin used in sealants can also classify them:

BIS-GMA (Bisphenol A Glycidyl Methacrylate)
A commonly used resin that provides good mechanical properties and
adhesion.


Urethane Acrylate
Offers enhanced flexibility and durability, making it suitable for
areas subject to stress.



3. Filled and Unfilled
Sealants can be categorized based on the presence of fillers:


Filled Sealants

Contain added particles that enhance strength and wear resistance.
They may provide better wear characteristics but can be more viscous and
difficult to apply.



Unfilled Sealants

Typically have a smoother flow and are easier to apply, but may not
be as durable as filled sealants.



4. Clear or Tinted
The color of the sealant can also influence its application:


Clear Sealants

Have better flow characteristics, allowing for easier penetration
into pits and fissures. They are less visible, which can be a
disadvantage in monitoring during follow-up visits.



Tinted Sealants

Easier for both patients and dentists to see, facilitating
monitoring and assessment during recalls. However, they may have
slightly different flow characteristics compared to clear sealants.



Application Process

Sealants are applied in a viscous liquid state that enters the
micropores of the tooth surface, which have been enlarged through acid
conditioning.
Once applied, the resin hardens due to either a self-hardening catalyst
or the application of a light source.
The extensions of the hardened resin that penetrate and fill the
micropores are referred to as "tags," which help in retaining the sealant on
the tooth surface.

Acrylic Appliances
Dental Materials

Acrylic Appliances

Use - space maintenance  or tooth movement for orthodontics and pediatric dentistry

1. Components

a. Powder-PMMA powder. peroxide initiator, and pigments

b. Liquid-MMA monomer, hydroquinone inhibitor, cross-linking agents, and chemical accelerators (N, N-dimethyl-p-toluidine)

2. Reaction

 PMMA powder makes mixture viscous for manipulation before curing . Chemical accelerators cause decomposition of benzoyl peroxide into free radicals that initiate polymerization of monomer .  New PMMA is formed into a matrix that surrounds PMMA powder. Linear shrinkage of 5% to 7% during setting. but dimensions of appliances are not critical

ENDODONTICS INTRACANAL MEDICAMENTS IN ROOT CANAL TREATMENT
Endodontics

Lamotrigine
Pharmacology

Lamotrigine (Lamictal): newer; broad spectrum (for most seizure types)

Mechanism: ↓ reactivation of Na channels (↑ refractory period, blocks high frequency cell firing)

Side effects: dizziness, ataxia, fatigue, nausea, no significant drug interactions

Glycogen storage diseases (glycogenoses)
General Pathology

Glycogen storage diseases (glycogenoses)

1. Genetic transmission: autosomal recessive.

2. This group of diseases is characterized by a deficiency of a particular enzyme involved in either glycogen production or degradative pathways.

Diseases include:
on Gierke disease (type I)
(a) Deficient enzyme: glucose-6-phosphatase.
(b) Major organ affected by the buildup of glycogen: liver.

Pompe disease (type II)

(1) Deficient enzyme: α-glucosidase(acid maltase).
(2) Major organ affected by the buildup of glycogen: heart.

Cori disease (type III)
(1) Deficient enzyme: debranching enzyme (amylo-1,6-glucosidase).
(2) Organs affected by the buildup of glycogen: varies between the heart, liver, or skeletal muscle.

Brancher glycogenosis (type IV)
(1) Deficient enzyme: branching enzyme.
(2) Organs affected by the buildup of glycogen: liver, heart, skeletal muscle, and brain.

McArdle syndrome (type V)
(1) Deficient enzyme: muscle phosphorylase.
(2) Major organ affected by the buildup of glycogen: skeletal muscle.

Behavioral Traits Associated with Parenting Styles
Pedodontics

Behavioral Traits Associated with Parenting Styles
Various behavioral traits that can be associated with different parenting
styles:

Overprotective: Children may become dominant, shy,
submissive, or anxious due to excessive protection.
Overindulgent: This can lead to aggressive, demanding
behavior, and frequent temper tantrums, but may also foster affectionate
traits.
Rejecting: Children may appear well-behaved but can
struggle with cooperation, often being shy and crying easily.
Authoritarian: This style may result in aggressive,
overactive, and disobedient behavior, with children being evasive and
dawdling.

Aggressive Periodontitis
Periodontology

Aggressive Periodontitis (formerly Juvenile Periodontitis)

Historical Names: Previously referred to as
periodontosis, deep cementopathia, diseases of eruption, Gottleib’s
diseases, and periodontitis marginalis progressive.
Risk Factors:
High frequency of Actinobacillus actinomycetemcomitans.
Immune defects (functional defects of PMNs and monocytes).
Autoimmunity and genetic factors.
Environmental factors, including smoking.


Clinical Features:
Vertical loss of alveolar bone around the first molars and incisors,
typically beginning around puberty.
Bone loss patterns often described as "target" or "bull" shaped
lesions.



Explore by Exams