NEET MDS Synopsis
Urine Formation
Physiology
Urine is a waste byproduct formed from excess water and metabolic waste molecules during the process of renal system filtration. The primary function of the renal system is to regulate blood volume and plasma osmolarity, and waste removal via urine is essentially a convenient way that the body performs many functions using one process. Urine formation occurs during three processes:
Filtration
Reabsorption
Secretion
Filtration
During filtration, blood enters the afferent arteriole and flows into the glomerulus where filterable blood components, such as water and nitrogenous waste, will move towards the inside of the glomerulus, and nonfilterable components, such as cells and serum albumins, will exit via the efferent arteriole. These filterable components accumulate in the glomerulus to form the glomerular filtrate.
Normally, about 20% of the total blood pumped by the heart each minute will enter the kidneys to undergo filtration; this is called the filtration fraction. The remaining 80% of the blood flows through the rest of the body to facilitate tissue perfusion and gas exchange.
Reabsorption
The next step is reabsorption, during which molecules and ions will be reabsorbed into the circulatory system. The fluid passes through the components of the nephron (the proximal/distal convoluted tubules, loop of Henle, the collecting duct) as water and ions are removed as the fluid osmolarity (ion concentration) changes. In the collecting duct, secretion will occur before the fluid leaves the ureter in the form of urine.
Secretion
During secretion some substances±such as hydrogen ions, creatinine, and drugs—will be removed from the blood through the peritubular capillary network into the collecting duct. The end product of all these processes is urine, which is essentially a collection of substances that has not been reabsorbed during glomerular filtration or tubular reabsorbtion.
METALLURGICAL TERMS
Dental Materials
METALLURGICAL TERMS
a. Cold Working. This is the process of changing the shape of a metal by rolling, pounding, bending, or twisting at normal room temperature.
b. Strain Hardening. This occurs when a metal becomes stiffer and harder because of continued or repeated application of a load or force. At this point, no further slippage of the atoms of the metal can occur without fracture.
c. Heat Softening Treatment (Annealing). This treatment is necessary in order to continue manipulating a metal after strain hardening to prevent it from fracturing. The process of annealing consists of heating the metal to the proper temperature (as indicated by the manufacturer's instructions) and cooling it rapidly by immersing in cold water. Annealing relieves stresses and strains caused by cold working and restores slipped atoms within the metal to their regular arrangement.
d. Heat Hardening Treatment (Tempering). This treatment is necessary to restore to metals properties that are decreased by annealing and cold working. Metals to be heat hardened should first be heat softened (annealed) so that all strain hardening is relieved and the hardening process can be properly controlled. Heat hardening is accomplished in dental gold alloy by heating to 840o Fahrenheit, allowing it to cool slowly over a 15-minute period to 480o Fahrenheit, and then immersing it in water.
Stages of manipulation
Definitions of intervals
Mixing interval-length of time of the mixing stage.
Working interval-length of time of the working stage
Setting interval-length of time of the setting stage
Definitions of times
Mixing time-the elapsed time from the onset to the completion of mixing
Working time-the elapsed time from the onset of mixing until the onset of the initial setting time
Initial setting time-time at which sufficient reaction has occurred to cause the materials to be resistant to further manipulation
Final setting time-time at which the material practically is set as defined by its resistance to indentation
[All water-based materials lose their gloss at the time of setting]
DNA (Deoxyribonucleic acid)
PhysiologyDNA (Deoxyribonucleic acid) - controls cell function via transcription and translation (in other words, by controlling protein synthesis in a cell)
Transcription - DNA is used to produce mRNA
Translation - mRNA then moves from the nucleus into the cytoplasm & is used to produce a protein . requires mRNA, tRNA (transfer RNA), amino acids, & a ribosome
tRNA molecule
sequence of amino acids in a protein is determined by sequence of codons (mRNA). Codons are 'read' by anticodons of tRNAs & tRNAs then 'deliver' their amino acid.
Amino acids are linked together by peptide bonds (see diagram to the right)
As mRNA slides through ribosome, codons are exposed in sequence & appropriate amino acids are delivered by tRNAs. The protein (or polypeptide) thus grows in length as more amino acids are delivered.
The polypeptide chain then 'folds' in various ways to form a complex three-dimensional protein molecule that will serve either as a structural protein or an enzyme.
Seborrheic keratosis
General Pathology
Seborrheic keratosis
1. A round, brown-colored, flat wart.
2. Most often seen in middle-aged to older adults.
3. A benign lesion.
Structures and best view X ray
Radiology
Fractures of the Zygomatic Arch
Structures: Zygomatic arch, zygomatic bone.
Best Views:
Submento-Vertex View: Provides a clear view of the
zygomatic arch and helps assess fractures.
Waters View: Useful for visualizing the zygomatic
bone and maxillary sinus.
Reverse Townes View: Can also be used to visualize
the zygomatic arch.
Base of Skull
Structures: Base of the skull, cranial fossae.
Best Views:
Submento-Vertex View: Effective for assessing the
base of the skull and related fractures.
Maxillary Sinus
Structures: Maxillary sinus, zygomatic bone.
Best Views:
Waters View: Excellent for visualizing the
maxillary sinus and any associated fractures.
Fractures of Zygoma
Structures: Zygomatic bone, zygomatic arch.
Best Views:
Waters View: Good for assessing zygomatic
fractures.
PA View: Provides a frontal view of the zygomatic
bone.
Reverse Townes View: Useful for visualizing the
zygomatic arch.
Nasal Septum
Structures: Nasal septum, nasal cavity.
Best Views:
PA View: Useful for assessing the nasal septum and
any associated fractures.
Condylar Neck Fractures
Structures: Mandibular condyle, neck of the condyle.
Best Views:
Lateral Oblique View (15°): Good for visualizing
condylar neck fractures.
Transpharyngeal View: Useful for assessing the
condylar region.
Medially Displaced Condylar Fractures
Structures: Mandibular condyle.
Best Views:
Lateral Oblique View (30°): Effective for
visualizing medially displaced condylar fractures.
Coronoid Process of Mandible
Structures: Coronoid process.
Best Views:
PA View of Skull: Can help visualize the coronoid
process.
Fractures of Ramus and Body of Mandible
Structures: Mandibular ramus, body of the mandible.
Best Views:
Lateral Oblique View (15°): Useful for assessing
fractures of the ramus and body of the mandible.
Horizontal Favorable and Unfavorable Fractures of Mandible
Structures: Mandible.
Best Views:
Lateral Oblique View (30°): Effective for
evaluating horizontal fractures.
Bony Ankylosis of TMJ
Structures: Temporomandibular joint.
Best Views:
CT Scan: Provides detailed imaging of bony
structures and ankylosis.
Fibrous Ankylosis of TMJ
Structures: Temporomandibular joint.
Best Views:
CT Scan: Useful for assessing fibrous ankylosis.
Internal Derangement of the Disk
Structures: TMJ disk.
Best Views:
MRI: The best modality for evaluating soft tissue
structures, including the TMJ disk.
Disk Perforation
Structures: TMJ disk.
Best Views:
MRI: Effective for diagnosing disk perforation.
Arthrography
Structures: TMJ.
Best Views:
Arthrography: Can be used to assess the TMJ and
visualize the disk and joint space.
Onlay Preparation
Conservative DentistryOnlay Preparation
Onlay preparations are a type of indirect restoration used to restore teeth
that have significant loss of structure but still retain enough healthy tooth
structure to support a restoration. Onlays are designed to cover one or more
cusps of a tooth and are often used when a full crown is not necessary.
1. Definition of Onlay
A. Onlay
An onlay is a restoration that is
fabricated using an indirect procedure, covering one or more cusps of a
tooth. It is designed to restore the tooth's function and aesthetics while
preserving as much healthy tooth structure as possible.
2. Indications for Onlay Preparation
Extensive Caries: When a tooth has significant decay
that cannot be effectively treated with a filling but does not require a
full crown.
Fractured Teeth: For teeth that have fractured cusps or
significant structural loss.
Strengthening: To reinforce a tooth that has been
weakened by previous restorations or caries.
3. Onlay Preparation Procedure
A. Initial Assessment
Clinical Examination: Assess the extent of caries or
damage to determine if an onlay is appropriate.
Radiographic Evaluation: Use X-rays to evaluate the
tooth structure and surrounding tissues.
B. Tooth Preparation
Burs Used:
Commonly used burs include No. 169 L for initial cavity preparation
and No. 271 for refining the preparation.
Cavity Preparation:
Occlusal Entry: The initial occlusal entry should
be approximately 1.5 mm deep.
Divergence of Walls: All cavity walls should
diverge occlusally by 2-5 degrees:
2 degrees: For short vertical walls.
5 degrees: For long vertical walls.
Proximal Box Preparation:
The proximal box margins should clear adjacent teeth by 0.2-0.5 mm,
with 0.5 ± 0.2 mm being ideal.
C. Bevels and Flares
Facial and Lingual Flares:
Primary and secondary flares should be created on the facial and
lingual proximal walls to form the walls in two planes.
The secondary flare widens the proximal box, allowing for better
access and cleaning.
Gingival Bevels:
Should be 0.5-1 mm wide and blend with the secondary flare,
resulting in a marginal metal angle of 30 degrees.
Occlusal Bevels:
Present on the cavosurface margins of the cavity on the occlusal
surface, approximately 1/4th the depth of the respective wall, resulting
in a marginal metal angle of 40 degrees.
4. Dimensions for Onlay Preparation
A. Depth of Preparation
Occlusal Depth: Approximately 1.5 mm to ensure adequate
thickness of the restorative material.
Proximal Box Depth: Should be sufficient to accommodate
the onlay while maintaining the integrity of the tooth structure.
B. Marginal Angles
Facial and Lingual Margins: Should be prepared with a
30-degree angle for burnishability and strength.
Enamel Margins: Ideally, the enamel margins should be
blunted to a 140-degree angle to enhance strength.
C. Cusp Reduction
Cusp Coverage: Cusp reduction is indicated when more
than 1/2 of a cusp is involved, and mandatory when 2/3 or more is involved.
Uniform Metal Thickness: The reduction must provide for
a uniform metal thickness of approximately 1.5 mm over the reduced cusps.
Facial Cusp Reduction: For maxillary premolars and
first molars, the reduction of the facial cusp should be 0.75-1 mm for
esthetic reasons.
D. Reverse Bevel
Definition: A bevel on the margins of the reduced cusp,
extending beyond any occlusal contact with opposing teeth, resulting in a
marginal metal angle of 30 degrees.
5. Considerations for Onlay Preparation
Retention and Resistance: The preparation should be
designed to maximize retention and resistance form, which may include the
use of proximal retentive grooves and collar features.
Aesthetic Considerations: The preparation should
account for the esthetic requirements, especially in anterior teeth or
visible areas.
Material Selection: The choice of material (e.g., gold,
porcelain, composite) will influence the preparation design and dimensions.
Thiamin: Vitamin B1
Biochemistry
Thiamin: Vitamin B1
Thiamin, or vitamin B1, helps to release energy from foods, promotes normal appetite, and is important in maintaining proper nervous system function.
RDA (Required Daily allowance) Males: 1.2 mg/day; Females: 1.1 mg/day
Thiamin Deficiency
Symptoms of thiamin deficiency include: mental confusion, muscle weakness, wasting, water retention (edema), impaired growth, and the disease known as beriberi.
The Effects of Enzyme Inhibitors
Biochemistry
The Effects of Enzyme Inhibitors
Enzymes can be inhibited
competitively, when the substrate and inhibitor compete for binding to the same active site or
noncompetitively, when the inhibitor binds somewhere else on the enzyme molecule reducing its efficiency.
The distinction can be determined by plotting enzyme activity with and without the inhibitor present.
Competitive Inhibition
In the presence of a competitive inhibitor, it takes a higher substrate concentration to achieve the same velocities that were reached in its absence. So while Vmax can still be reached if sufficient substrate is available, one-half Vmax requires a higher [S] than before and thus Km is larger.
Noncompetitive Inhibition
With noncompetitive inhibition, enzyme molecules that have been bound by the inhibitor are taken out
enzyme rate (velocity) is reduced for all values of [S], including
Vmax and one-half Vmax but
Km remains unchanged because the active site of those enzyme molecules that have not been inhibited is unchanged.