Increase the rate of liver metabolism of local anesthetic: Alpha adrenergic agonists, such as epinephrine, are often added to local anesthetics to enhance their effectiveness. They achieve this by causing vasoconstriction at the injection site, which reduces bleeding and increases the duration of anesthesia. However, they do not directly increase the concentration of LA at the receptor site or alter liver metabolism. Therefore, the correct answer is 2) Increase the concentration of LA at receptor site.