Dentinogenesis is the formation of dentin by odontoblasts of mesenchymal origin
located at the periphery of the dental pulp
Dentinogenesis is initiated by the inductive influence of the enamel organ
involving molecular signaling pathways, such as Wnt, Runx-2, and TGF-?. In the
molar tooth, dentinogenesis starts at the late bell stage, and occurs in the
crown as well as root regions.
Predentin, the first organic matrix secreted by odontoblasts, is composed by
proteoglycans, glycoproteins, and collagens.