Ventilation/perfusion ratio is highest in the apex of lung

Chronic bronchitis may result in cor pulmonale, increased airway resistance, metaplasia and dysplasia of respiratory epithelium

In the initial phase of treatment for hemochromatosis, phlebotomy is usually performed once a week to rapidly reduce iron stores. Once transferrin saturation and serum ferritin levels become normal, the frequency is typically reduced to every three months for maintenance.

Lupus nephritis is the most common complication of chronic SLE, affecting approximately 50% of patients. It is characterized by inflammation of the kidneys and can lead to kidney failure if not properly managed.

The ATP7B protein is essential for copper excretion from hepatocytes into bile, and its deficiency leads to copper accumulation in the liver and other tissues in Wilson's disease.