Dentinogenesis is the formation of dentin by odontoblasts of mesenchymal origin located at the periphery of the dental pulp

Dentinogenesis is initiated by the inductive influence of the enamel organ involving molecular signaling pathways, such as Wnt, Runx-2, and TGF-?. In the molar tooth, dentinogenesis starts at the late bell stage, and occurs in the crown as well as root regions.

Predentin, the first organic matrix secreted by odontoblasts, is composed by proteoglycans, glycoproteins, and collagens.

The most constant and valuable trait to differentiate among maxillary first second and third molars is the depth of central fossae

The primary mandibular central incisors usually erupt at 6-8 months

The average overall length of the permanent maxillary central incisor is 22.5 mm

In the case of primary teeth, the roots are often resorbed as the permanent teeth develop. The facial aspect of the root tends to be the last area to undergo resorption due to its position and the way the succedaneous tooth exerts pressure. The facial root surface is generally more stable and remains attached to the gingiva longer than the other aspects, making it the longest and most securely attached during extraction.