Cephalosporins can cause allergic reactions in people with penicillin allergy. The overall rate of allergy to cephalosporins in people with penicillin allergy is approximately 5 to 10%, although rates may be higher for certain people. Allergic reactions to cephalosporins can be severe and even lifethreatening;
it is generally recommended that those allergic to penicillin avoid cephalosporins all together.

Morphine causes vomiting by stimulation of the medullary chemo receptor trigger zone

In humans, isosorbide mononitrate is not subject to first pass metabolism in the liver.

This reduces the intra- and interindividual variations in plasma evels and leads to predictable and reproducible clinical effects.

To reverse the effect of overdose of oral anticoagulants:
Phytonadione (K1) is the preparation of choice, because it acts most rapidly, dose depends on the severity of upoprothrombinemia & bleeding.

Beta-blockers, such as propranolol, labetalol, and pindolol, can have membrane stabilizing effects (eg, quinidinelike effects, Vaughan-Williams class I antiarrhythmic effects). This property, usually not evident with therapeutic doses, may significantly contribute to toxicity by prolonging QRS duration and impairing cardiac conduction. Seizures are more commonly observed in the drugs with quinidinelike membrane stabilizing effects.