Heparin-associated thrombocytopenia may be associated with irreversible aggregation of platelets and treating venous thromboembolism. The incidence of thrombocytopenia after administration of LMWH is lower than with standard heparin. Adverse drug reactions like those caused by standard heparin have been seen during therapy with LMWH, and overdose is treated with protamine.

Oprelvekin (Interleukin 11) is the only agent approved by the FDA for treatment of thrombocytopenia secondary to myelosuppressive cancer chemotherapy
Filgrastim (G-CSF) and Sargramostim (GM-SCF) are used in the treatment of neutropenia
Erythropoietin is used in treatment of anemia

Other drugs with narrow therapeutic index:

Digoxin Gentamicin Amphotericin B Levothyroxine Prazosin Theophylline Quinidine Warfarin Valproic acid

Dimercaprol (British antilewisite; BAL)  

1. Poisoning by As, Hg, Au, Bi, Ni, Sb: it is administered i.m., 5 mg/kg stat, followed by 2-3 mg/kg every 4 – 8 hours for 2 days, then once or twice a day for 10 days. It is partly oxidized and glucuronide conjugated, but mainly excreted as such in 4 – 6 hours. Earlier the treatment is instituted, the better it is. Because the dimercaprolmetal complex dissociates faster in acidic urine and the released metal can damage the kidney, urine is alkalinized during dimercaprol therapy. 

2. As an adjuvant to Cal. Disod. Edentate in lead poisoning. 

3. As an adjuvant to penicillamine in Cu poisoning and in Wilson’s disease – 300 mg/day i.m. for 10 days every second month.  

It is contraindicated in iron and cadmium poisoning, because the dimercaprol-Fe and dimercaprol-Cd complex is itself toxic.

carbamazepine is the primary agent used in ment of trigeminal neuralgia