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NEET MDS Shorts

50247
Pharmacology

Adrenaline is contraindicated in hypertensive, hyperthyroid and angina patient.

Hypersensitivity to drug is absolute contraindication to any drug.

11314
Pharmacology

Functions of delta type opioid receptors are:

supraspinal analgesia 
spinal analgesia 
modulation of hormone and neurotransmitter release

79426
Pharmacology

Long acting non-depolarizing (competitive) NM blocking agents require reversal with neostigmine.
Mivacurium is the shortest acting NDMR. It does not require reversal due to its short duration of action.
Mivacurium can be used in day care surgery.

80842
Pharmacology

Cisapride can cause QT prolongation when administered along with drugs like ketoconazole which inhibit hepatic cytochrome p-450 CYP 3A4 enzyme.

69400
Pharmacology

Gingivitis is a form of periodontal disease. Periodontal disease is when inflammation and infection destroy the tissues that support the teeth, including the gingiva (gums), the periodontal ligaments, and the tooth sockets (alveolar bone Malocclusion of teeth (misaligned teeth), rough edges of fillings, and ill fitting or unclean mouth appliances (such as orthodontic appliances, dentures, bridges, and crowns) can irritate the gums and increase the risk of gingivitis.

Medications such as phenytoin and birth control pills, and ingestion of heavy metals such as lead and bismuth are also associated with gingivitis.

71266
Pharmacology

Permanent auditory nerve deafness is frequently associated with use of streptomycin

48846
Pharmacology

less solublity in blood means more rapid induction, however quicker emergence after discontinuing depends upon solublity and redistribution in lipids of body as well

89562
Pharmacology

It is also used to treat ventricular tachycardia and to perform nerve blocks

Dosage Of Local Anesthesia:

1) Safety dose of 2% Lignocaine is 4.5mg/kg without a Vasoconstrictor

Without a Vasoconstrictor 300 mg (maximum dose)

2) Safety dose of 2% Lignocaine is 7mg/kg with a Vasoconstrictor

With a Vasoconstrictor – 500 mg (maximum dose)

3) As 1ml of 2% Lignocaine contains 20mg – Where the Maximum safety dose being 300 mg 

So 15 ml of Drug can be given safely

4) 1:1,00,000 concentration means 1 part of Adrenaline is 1,00,000 parts of Solution

Safety Dose of Adrenaline for Dental Use in normal patients is 0.2 mg – which means 20 ml of LA can be given to normal patients containing Adrenaline

For cardiac Patients the safety dose of Adrenaline is 0.04mg – Which means 4ml of LA can be given to Patients with cardiac problems containing Adrenaline

5) If the concentration of LA is 1:50,000 – 10 ml of LA can be given safely

90269
Pharmacology

Vasopressin antagonists like tolvaptan are aquaretics

68087
Pharmacology

Acetazolamide is a carbonic acid anhydrase stimulant Acetazolamide, non-competitively (but reversibly) inhibits carbonic anhydrase in proximal tubular cells.

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