MDS PREP
The first person becoming sick in an epidemic is called -
1. Primary case
2. Source of infection
3. Reservoir of infection
4. Index case
Microbiology
Answer: 4
The first recognized case in an epidemic outbreak is termed as the index case. Although both the index case and primary case appear to be the same yet they differ slightly. The term primary case refers to the person who first brings a disease into a group of people.
What does the Vi antigen of S. typhi confer upon the bacterium?
1) Resistance to antibiotics
2) Increased invasiveness
3) Resistance to phagocytosis
4) Resistance to acidic environment
General Microbiology Answer: 3the Vi antigen of S. typhi confers upon the bacterium Resistance to phagocytosis. The Vi antigen is a polysaccharide capsule that protects the bacteria from being engulfed and destroyed by phagocytic white blood cells, contributing to its virulence.
Which of the following is a feature of HLA class I antigens?
1) Found on red blood cells
2) Involved in humoral immunity
3) Present on all nucleated cells
4) Only present in lymphocytes
HLA class I antigens are present on all nucleated cells, playing a crucial role in the immune response.
Which of the following is a feature of the immune response involving HLA class I antigens?
1) They activate B cells
2) They present antigens to CD4+ T cells
3) They are involved in graft rejection
4) They are only present in the thymus
General Microbiology Answer: 3HLA (Human Leukocyte Antigen) class I antigens are crucial in the immune response to infections and also play a significant role in graft rejection. They present antigens to CD8+ T cells (cytotoxic T cells), which then target and destroy infected or foreign cells. While they do not directly activate B cells or CD4+ T cells, they are involved in the recognition of cells by the adaptive immune system and thus are important in the overall immune response.
The most pronounced effect on the oral microflora of a reduction in rate of salivary flow is a
1. significant increase in number of oral bacteria
2. shift towards a more acidogenic microflora
3 significant decrease in number of oral bacteria
4 shift towards a more aerobic micro flora
Microbiology
Answer: 2
The most pronounced effect on the oral microflora of a reduction in rate of salivary flow is a shift towards a more acidogenic microflora
What is a key characteristic of the colonies formed by Streptococcus pneumoniae?
1) Dome-shaped
2) Initially dome-shaped, later draughtsman colonies
3) Granular turbidity with a powdery deposit
4) Not typically seen in culture
Streptococcus pneumoniae colonies are initially dome-shaped and later develop draughtsman colonies.
Which of the following statements is true regarding Bacillus anthracis?
1) It is motile.
2) It is capsulated.
3) It grows in short chains.
4) It is susceptible to chloral hydrate.
Bacillus anthracis is capsulated, which is a key feature of its virulence.
There are some enzymes that cause protein to coagulate rather than to produce simpler compund These are known as
1. lab enzymes
2. coagulase
3. proteolytic enzymes
4. wenmycin
Microbiology
Answer: 1
There are some enzymes that cause protein to coagulate rather than to produce simpler compund These are known as lab enzymes
1. Coagulase:
Definition: Coagulase is an enzyme produced by certain
bacteria, most notably Staphylococcus aureus. It catalyzes the
conversion of fibrinogen (a soluble plasma protein) into fibrin (an
insoluble protein), leading to the clotting of blood.
Function: The production of coagulase is a virulence
factor for Staphylococcus aureus, as it helps the bacteria evade
the host's immune system by forming a protective clot around the bacterial
cells. This clot can shield the bacteria from phagocytosis and other immune
responses.
Clinical Relevance: Coagulase is used in laboratory
tests to differentiate between pathogenic Staphylococcus aureus (coagulase-positive)
and non-pathogenic staphylococci (coagulase-negative).
2. Proteolytic Enzymes:
Definition: Proteolytic enzymes, also known as
proteases or peptidases, are enzymes that catalyze the breakdown of proteins
into smaller peptides or amino acids by cleaving the peptide bonds between
amino acids.
Function: These enzymes play crucial roles in various
biological processes, including digestion, protein turnover, cell signaling,
and immune responses. They are found in many organisms, including humans,
where they are involved in the digestion of dietary proteins in the stomach
and small intestine.
Types: Proteolytic enzymes can be classified based on
their mechanism of action (e.g., serine proteases, cysteine proteases,
aspartic proteases, and metalloproteases) and their substrate specificity.
Wenmycin is an antibiotic that is derived from the
bacterium Streptomyces wenyangensis. It belongs to the class of
compounds known as macrolide antibiotics, which are
characterized by their large lactone ring structure. Wenmycin has been studied
for its antimicrobial properties, particularly against certain types of
bacteria.