MDS PREP
What is the name of the live oral vaccine for typhoid fever and what is its mechanism of action?
1) Typhoral, a Gal E mutant of S. typhi that "self-destructs" after a few cell divisions
2) CholeraVax, a killed whole-cell vaccine
3) Salmonellosis vaccine, a live attenuated strain of S. paratyphi
4) Shigellosis vaccine, a bacteriophage preparation
General Microbiology Answer: 1the live oral vaccine for typhoid fever is Typhoralx, which is a Gal E mutant of S. typhi. The mechanism of action involves the attenuated bacteria colonizing the intestinal mucosa and inducing an immune response that protects against subsequent infection with the pathogenic strain.
Which of the following statements is true about the colony morphology and cultural characteristics of Anthrax bacilli?
1) Anthrax bacilli are motile and produce a turbidity in broth.
2) The Medusa head appearance is seen in non-virulent strains of anthrax bacilli.
3) Virulent capsulated strains form smooth colonies.
4) The inverted fir tree appearance is characteristic of Anthracoid bacilli.
The Medusa head appearance is characteristic of virulent strains of anthrax bacilli, not non-virulent strains.
Which of the following acids is intermediate in the biosynthesis the cell wall?
1. Alanyl diaminopimelic
2. L-glutamic
3 Uridylic
4. N-acetyl muramic
Microbiology
Answer: 4
N-acetyl muramic is intermediate in the biosynthesis the cell wall
The main tool for detection of "cases" of tuberculosis is -
1. Sputum examination
2. Mantoux test
3. Chest X-ray
4. All of the above
Microbiology
Answer: 1
The main tool for the detection of "cases" of tuberculosis is 1.
Sputum examination.
Explanation of Each Option:
Sputum examination: This is the primary method for
diagnosing active pulmonary tuberculosis. Sputum samples are collected and
examined for the presence of Mycobacterium tuberculosis through
microscopy (e.g., acid-fast bacilli staining) and culture methods. It is
considered the gold standard for confirming active TB cases.
Mantoux test: Also known as the tuberculin skin test,
this test is used to determine if a person has been exposed to the
tuberculosis bacteria. However, it does not diagnose active TB; rather, it
indicates whether a person has been infected with the bacteria at some
point.
Chest X-ray: While chest X-rays are important for
identifying lung abnormalities associated with tuberculosis and can support
the diagnosis, they are not definitive for detecting the bacteria itself.
They are often used in conjunction with sputum examination.
Which of the following is a killed viral vaccine?
1) Sabin vaccine for poliomyelitis
2) Salk vaccine for poliomyelitis
3) MMR vaccine for measles, mumps, rubella
4) Varicella-zoster
General Microbiology Answer: 2
The Salk vaccine for poliomyelitis is a killed viral vaccine, effectively preventing the disease by using inactivated poliovirus.
What is the effect of Actinomycin D on orthomyxoviruses?
1) Stimulates multiplication
2) Inhibits multiplication
3) No effect
4) Enhances stability
General Microbiology Answer: 2Actinomycin D is an antibiotic that inhibits RNA synthesis. In the case of orthomyxoviruses, it effectively inhibits their multiplication by preventing the transcription of viral RNA, thereby blocking the virus ability to replicate. Actinomycin D inhibits the multiplication of orthomyxoviruses by blocking RNA synthesis, which is crucial for viral replication.
Most bacterial endotoxins are composed of
1. pure carbohydrates
2. mucoprotein complexes
3. pure lipids
4. lipoprotein-polysaccharide complexes
Microbiology
Answer: 4
Most bacterial endotoxins are composed of lipoprotein-polysaccharide complexes
What is the diameter of prions?
1) 2-4 nm
2) 4-6 nm
3) 10-12 nm
4) 20-25 nm
General Microbiology Answer: 2Prions are extremely small infectious agents, typically measuring between 4 to 6 nanometers in diameter. Their small size contributes to their ability to evade the immune system and resist conventional sterilization methods.