MDS PREP
Which of the following antiviral drugs cannot be given orally?
1) Zidovudine
2) Zalcitabine
3) Acyclovir
4) Iodoxuridine
Pharmacology Answer: 4
Idoxuridine acts as an antiviral agent against DNA viruses by inhibiting thymidilate phosphorylase and viral DNA polymerases.
The effect of Idoxuridine results in the inability of the virus to reproduce or to infect/destroy tissue.
This product is available in the following dosage forms:Solution and Ointment
The Beta Blocker with local Anesthetic effect is
1) Pindolol
2) Atenolol
3) Esmorolol
4) Timolol
Pharmacology Answer: 1
Local anesthetic action, also known as "membrane-stabilizing" action, is a prominent effect of several -blockers Acebutolol, Labetalol, Pindolol Propranolol.
This action is the result of typical local anesthetic blockade of sodium channels and can be demonstrated experimentally in isolated neurons, heart muscle, and skeletal muscle membrane.
The main excitatory neuro transmitter in CNS is
1) Glycine
2) Acetyl choline
3) Aspartate
4) Glutamate
Pharmacology Answer: 2
The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS)and central nervous system (CNS) in many organisms including humans. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmiter used in the somatic nervous system.
Heparin
1) is a glycosaminoglycan
2) potentiates thrombin
3) has a half life of 3-4 hours
4) is normally given IM
Pharmacology Answer: 1
GlycosaminoglycAnswer (GAGs) are heteropolysaccharides. These molecules are long unbranched polysaccharides containing a repeating disaccharide unit. The disaccharide units contain either of two modified sugars N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc) and a uronic acid such as glucuronate or iduronate. The specific GAGs of physiological significance are hyaluronic acid, dermatan sulfate, chondroitin sulfate, heparin, heparan sulfate, and keratan sulfate.
Morphine withdrawal is characterized by all except
1) Miosis
2) Yawning
3) Lacrimation
4) Diarrhea
Pharmacology Answer: 1
Withdrawal of morphine is associated with marked drug-seeking behavior.
Physical manifestations of abstinence are - lacrimation, sweating, yawning, anxiety, fear, restlessness, gooseflesh, mydriasis, tremor, insomnia, abdominal colic, diarrhea, dehydration, rise in BP, palpitation and rapid weight loss.
Delirium and convulsions are not a characteristic feature (contrast barbiturates) and are seen only occasionally.
Cardi-ovascular collapse and fatality are rare if supportive measures are instituted.
Developed hypo reactivity to a drug is
1) Detoxification
2) Antagonism
3) Tolerance
4) Desensitization
Pharmacology Answer: 3
Tolerance: The capacity to absorb a drug continuously or in large doses without adverse effect; diminution in the response to a drug after prolonged use.
Which of the following antihypertensive drugs should not be used in a patient on Lithium in order to prevent Lithium Toxicity?
1) Clonidine
2) Beta blockers
3) Calcium Channel Blockers
4) Diuretics
Pharmacology Answer: 4
Diuretics increase sodium loss in urine and increase lithium retention. Hence they should not be used in patients on Lithium.
The administration of penicillin G along with probenacid results in
1. increased excretion of probenacid in the feces and perspiration
2. increased excretion of probenacid in urine
3. increased metabolism of penicillin G
4. decreased renal excretion of penicillin G
Pharmacology Answer: 4
The administration of penicillin G along with probenacid results in decreased renal excretion of penicillin G