MDS PREP
Which of the following statements is not true regarding sulfonamides:
1) Sulfasalazine is absorbed well from GIT
2) Crystalluria can occur with sulfonamide administration
3) Sulfonamide administration to Newborn may cause Kernicterus
4) Sulfonamides are of value in treatment of infections due to Norcardia species
Pharmacology Answer: 1
Sulfasalazine is absorbed well from GIT
Sulfasalazine is poorly absorbed (10-20%) from the GIT .
Which of the following is used for the treatment of chlamydia infection in pregnancy?
1) Tetracycline
2) Erythromycin
3) Azithromycin
4) Doxycycline
Pharmacology Answer: 3
Azithromycin Preferred agent for treatment of chlamydia infection in pregnancy in azithromycin.
It is given as a single dose of 1g leading to high compliance rate.
False statement regarding phenytoin is?
1) It is a teratogenic drug
2) Highly protein bound
3) Induces insulin secretion
4) Follows saturation kinetics
Pharmacology Answer: 3
Phenytoin inhibits insulin secretion and causes hyperglycemia.
MAO inhibitors are contraindicated in a patient taking?
1) Pethidine
2) Buprenorphine
3) Morphine
4) Pentazocine
Pharmacology Answer: 1
first choice pethidine
Use of MAO inhibitors in patient taking pethidine / pentazocine can precipitate serotonin syndrome.
Nonselective beta blocker possessing quinidine-like membrane stabilizing effects.
1) pindolol
2) acebutolol
3) sotalol
4) esmolol
Pharmacology Answer: 1
Beta-blockers, such as propranolol, labetalol, and pindolol, can have membrane stabilizing effects (eg, quinidinelike effects, Vaughan-Williams class I antiarrhythmic effects). This property, usually not evident with therapeutic doses, may significantly contribute to toxicity by prolonging QRS duration and impairing cardiac conduction. Seizures are more commonly observed in the drugs with quinidinelike membrane stabilizing effects.
The drug of choice for the treatment of thyrotoxicosis during pregnancy is?
1 Carbimazole
2 Iodine therapy
3 Propylthiouracil
4 Metimazole
Pharmacology Answer: 3
Thyroid inhibitors
a) Inhibit hormone synthesis (anti thyroid drugs): Propylthiouracil, Methimazole, Carbimazole
b) Inhibit iodine trapping (ionic inhibitors): Thiocyanates, Perchlorates, Nitrates.
c) Inhibit hormone release: Iodine, NaI, Kl
d) Destroy thyroid tissue: Radioactive iodine
Which of the following antibiotics shows an incidence of approximately 8% cross-allergencity with penicillins?
1) Bacitracin
2) Erythromycin
3) Cephalexin
4) Vancomycin
Pharmacology Answer: 3
Cephalosporins can cause allergic reactions in people with penicillin allergy. The overall rate of allergy to cephalosporins in people with penicillin allergy is approximately 5 to 10%, although rates may be higher for certain people. Allergic reactions to cephalosporins can be severe and even lifethreatening;
it is generally recommended that those allergic to penicillin avoid cephalosporins all together.
All of the following statements are true regarding the cephalosporin
antibiotics except
1). they are bactericidal
2). they are ineffective against gram negative microorganisms
3). they are potentially cross allergenic with penicillin
4). they are resistant to penicillinase
Pharmacology Answer: 2
cephalosporin are bactericidal, are potentially cross allergenic with penicillin, resistant to penicillinase