MDS PREP
The drug currently in wide use for treating opioid dependent individuals
1. methadone
2. pentazocine
3. alphaprodine
4. meperidine
Pharmacology
Answer: 1
The drug currently in wide use for treating opioid dependent individuals is metahdone
The effects of hypoglycemia is marked by
1) Warfarin
2) Beta blockers
3) Calcium channel blockers
4) Amino glycosides
Pharmacology Answer: 2
Beta blockers
Hypoglycemia can occur with beta-blockade because b2- adrenoceptors normally stimulate hepatic glycogen breakdown (glycogenolysis) and pancreatic release of glucagon, which work together to increase plasma glucose.
Which of the following is used in the treatment of meningococcal meningitis in patients allergic to penicillin?
1) Ciprofloxacin
2) Teicoplanin
3) Meropenem
4) Chloramphenicol
Pharmacology Answer: 4
Treatment of meningococcal meningitis:
Drug of choice – Penicillin G
In case of penicillin resistance, third generation cephalosporins should be used ( Ceftriaxone / CefotaximeIn case of penicillin / cephalosporin allergy, Chloramphenicol is used
Which of the following is a Beta-1 selective blocker ?
1) propranolol
2) nadolol
3) pindolol
4) betaxolol
Pharmacology Answer: 4
Beta-1 selective blockers
These include atenolol and metoprolol (as well as betaxolol, bevantolol, and perhaps esmolol).
Non-selective beta blockers
propranolol
One of the side-effects of prilocaine is
1) Gastric bleeding
2) Porphyria
3) Photophobia
4) Methemoglobinemia
Pharmacology Answer: 4
Methemoglobinemia is a condition in which the iron within hemoglobin is oxidized from the ferrous (Fe2+) state to the ferric (Fe3+) state, resulting in the inability to transport oxygen and carbon dioxide. Clinically, this condition causes cyanosis, often posing a diagnostic dilemma
usually results from exposure to oxidizing substances (such as nitrates or nitrites, aniline dyes, or medications, including lidocaine, prilocaine, phenazopyridine hydrochloride (Pyridium], and others)
Which of the following is used for the treatment of chlamydia infection in pregnancy?
1) Tetracycline
2) Erythromycin
3) Azithromycin
4) Doxycycline
Pharmacology Answer: 3
Azithromycin Preferred agent for treatment of chlamydia infection in pregnancy in azithromycin.
It is given as a single dose of 1g leading to high compliance rate.
Drugs mostly cross biological membranes by
1) Passive diffusion
2) Active diffusion
3) Active transport
4) Carrier mediated transport
Pharmacology Answer: 1
Passive diffusion: The movement of drug across a membrane in a manner driven solely by the concentration gradient. In passive diffusion, drug moves from a region of greater concentration to a region of lesser concentration.
Which of the following agents is used for the treatment of Thrombocytopenia secondary to myelosuppressive cancer chemotherapy?
1) Filgrastim
2) Sargramostim
3) Oprelvekin
4) Erythropoietin
Pharmacology Answer: 3
Oprelvekin (Interleukin 11) is the only agent approved by the FDA for treatment of thrombocytopenia secondary to myelosuppressive cancer chemotherapy
Filgrastim (G-CSF) and Sargramostim (GM-SCF) are used in the treatment of neutropenia
Erythropoietin is used in treatment of anemia