MDS PREP
Which of the following are anti-fungal drugs?
1) Cloxacillin
2) Aciclovir
3) Chlorhexidine
4) Nystatin
Pharmacology Answer: 4
Miconazole is an imidazole anti-fungal drug, Nystatin is a polyene anti-fungal drug and itraconazole is a triazole anti-fungal.
Aciclovir is an anti-viral drug and chlorhexidine is an antiseptic.cloxacillin is penicillin derivative.
Which of the following fluoroquinolones does not require dose adjustment in a patient with creatinine clearance of < 50mg/min?
1) Ciprofloxacin
2) Trovafloxacin
3) Lomefloxacin
4) Sparfloxacin
Pharmacology Answer: 2
Fluoroquinolones that are excreted mainly by non renal mechanisms:
Pefloxacin Trovafloxacin Grepofloxacin Nalidixic acid
The administration of barbiturates is contraindicated in :
1) Anxiety disorders
2) Acute intermittent prophyria
3) Kernicterus
4) Refractive status epilepticus
Pharmacology Answer: 2
Acute intermittent prophyria (AIP) : Barbiturates exacerbate it by inducing microsomal enzymes and d amino levulinic acid synthetase and increasing prophyrin synthesis.
Note: Contraindications of barbiturates : · Liver and kidney disease · Severe pulmonary insufficiency eg. Emphysema · Obstructive sleep apnoea
Ethohepatazine is a chemical derivative of
1. codeine
2. morphine
3. meperidine
4. papaverine
Pharmacology
Answer: 3
Ethohepatazine is a chemical derivative of meperidine
Morphine can be used in all the following conditions except:
1) Head injury
2) Asthma
3) Hypothyroidism
4) Diabetes
Pharmacology Answer: 1
Morphine is contraindicated in head injury for the following reasons:
Causes carbondioxide retention – this in turn increases intracranial tension
Therapeutic doses can cause respiratory depression in head injury patients Vomiting, miosis and altered mentation caused by morphine can interfere with assessment of neurological status
Morphine should be avoided in those with bronchial asthma as it can precipitate an attack of asthma. But it is not contraindicated
A medication that is associated with gingivitis
1) phenytoin
2) carbamazepine
3) propranolol
4) diazepam
Pharmacology Answer: 1
Gingivitis is a form of periodontal disease. Periodontal disease is when inflammation and infection destroy the tissues that support the teeth, including the gingiva (gums), the periodontal ligaments, and the tooth sockets (alveolar bone Malocclusion of teeth (misaligned teeth), rough edges of fillings, and ill fitting or unclean mouth appliances (such as orthodontic appliances, dentures, bridges, and crowns) can irritate the gums and increase the risk of gingivitis.
Medications such as phenytoin and birth control pills, and ingestion of heavy metals such as lead and bismuth are also associated with gingivitis.
The main excitatory neuro transmitter in CNS is
1) Glycine
2) Acetyl choline
3) Aspartate
4) Glutamate
Pharmacology Answer: 2
The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS)and central nervous system (CNS) in many organisms including humans. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmiter used in the somatic nervous system.
Drugs mostly cross biological membranes by
1) Passive diffusion
2) Active diffusion
3) Active transport
4) Carrier mediated transport
Pharmacology Answer: 1
Passive diffusion: The movement of drug across a membrane in a manner driven solely by the concentration gradient. In passive diffusion, drug moves from a region of greater concentration to a region of lesser concentration.