MDS PREP
Current evidence indicates that endorphins are
1. endogenous molecules having morphine like properties
2. receptors located in the periaqueductal grey area of the brain Which are sensitive to opiates
3. large polypeptides that regulate renal activity
4. central nervous system transmitters implicated in depressive psychoses
Pharmacology
Answer: 1
endorphins are endogenous molecules having morphine like properties
The Beta Blocker with local Anesthetic effect is
1) Pindolol
2) Atenolol
3) Esmorolol
4) Timolol
Pharmacology Answer: 1
Local anesthetic action, also known as "membrane-stabilizing" action, is a prominent effect of several -blockers Acebutolol, Labetalol, Pindolol Propranolol.
This action is the result of typical local anesthetic blockade of sodium channels and can be demonstrated experimentally in isolated neurons, heart muscle, and skeletal muscle membrane.
The drug of choice for the treatment of thyrotoxicosis during pregnancy is?
1 Carbimazole
2 Iodine therapy
3 Propylthiouracil
4 Metimazole
Pharmacology Answer: 3
Thyroid inhibitors
a) Inhibit hormone synthesis (anti thyroid drugs): Propylthiouracil, Methimazole, Carbimazole
b) Inhibit iodine trapping (ionic inhibitors): Thiocyanates, Perchlorates, Nitrates.
c) Inhibit hormone release: Iodine, NaI, Kl
d) Destroy thyroid tissue: Radioactive iodine
Which drug is most effective in reducing mortality in patients with left ventricular systolic dysfunction ?
1) Enalapril
2) Aspirin
3) Digoxin
4) Frusemide
Pharmacology Answer: 1
ACE inhibition has a beneficial impact on survival rates, functional status, and hemodynamics in patients with left ventricular systolic dysfunction.
In the renin-angiotensin system, a fall in perfusion pressure stimulates the juxtaglomerular cells in the kidney to release the enzyme renin.
Renin cleaves the decapeptide angiotensin I from angiotensinogen, a glycoprotein synthesized in the liver.
The octapeptide angiotensin II is formed by the action of ACE on angiotensin I.
Angiotensin II is a potent vasoconstrictor and stimulates the release of aldosterone and norepinephrine.
Following drug interact with cefotaxime?
1) Digoxin
2) Paracetamol
3) Loop diuretics
4) Nifedipine
Pharmacology Answer: 3
Nephrotoxicity of cephalosporins is accentuated by concurrent administration of loop diuretics.
The following prevent re-uptake of noradrenaline
1) isoprenaline
2) dopamine
3) clomipramine
4) propranolol
Pharmacology Answer: 3
Is a TCA- block neuronal uptake of noradrenaline and serotonin. and thus increase its conc. at synapse. they also block muscarinic, histaminergic, and adrenergic receptor
Nonselective beta blocker possessing quinidine-like membrane stabilizing effects.
1) pindolol
2) acebutolol
3) sotalol
4) esmolol
Pharmacology Answer: 1
Beta-blockers, such as propranolol, labetalol, and pindolol, can have membrane stabilizing effects (eg, quinidinelike effects, Vaughan-Williams class I antiarrhythmic effects). This property, usually not evident with therapeutic doses, may significantly contribute to toxicity by prolonging QRS duration and impairing cardiac conduction. Seizures are more commonly observed in the drugs with quinidinelike membrane stabilizing effects.
Drug implicated for prolonging QT interval in a premature baby is :
1) Domperidone
2) Metoclopramide
3) Cisapride
4) Omeprazole
Pharmacology Answer: 3
Cisapride can cause QT prolongation when administered along with drugs like ketoconazole which inhibit hepatic cytochrome p-450 CYP 3A4 enzyme.