MDS PREP
Drugs mostly cross biological membranes by
1) Passive diffusion
2) Active diffusion
3) Active transport
4) Carrier mediated transport
Pharmacology Answer: 1
Passive diffusion: The movement of drug across a membrane in a manner driven solely by the concentration gradient. In passive diffusion, drug moves from a region of greater concentration to a region of lesser concentration.
In Dicumarol poisoning which Vit K is used
1) Menadione
2) Menaqunone
3) Phytonadione
4) None of the above
Pharmacology Answer: 3
To reverse the effect of overdose of oral anticoagulants:
Phytonadione (K1) is the preparation of choice, because it acts most rapidly, dose depends on the severity of upoprothrombinemia & bleeding.
False statement regarding phenytoin is?
1) It is a teratogenic drug
2) Highly protein bound
3) Induces insulin secretion
4) Follows saturation kinetics
Pharmacology Answer: 3
Phenytoin inhibits insulin secretion and causes hyperglycemia.
The Nitrate which does not undergo first pass metabolism is:
1) Isosorbide mononitrate
2) Nitroglycerine
3) Pentaerythritol tetranitrate
4) Isosorbide dinitrate
Pharmacology Answer: 1
In humans, isosorbide mononitrate is not subject to first pass metabolism in the liver.
This reduces the intra- and interindividual variations in plasma evels and leads to predictable and reproducible clinical effects.
The penicillin with the best gram negative spectrum is
1. methicillin
2. phenethicillin
3. ampicillin
4. penicillin V
Pharmacology
Answer: 3
The penicillin with the best gram negative spectrum is ampicillin
Drug class causing free water clearance:
a) Diuretic
b) Saluretic
c) Uricosuric
d) Aquaretic
Pharmacology Answer: 4
Vasopressin antagonists like tolvaptan are aquaretics
The Beta Blocker with local Anesthetic effect is
1) Pindolol
2) Atenolol
3) Esmorolol
4) Timolol
Pharmacology Answer: 1
Local anesthetic action, also known as "membrane-stabilizing" action, is a prominent effect of several -blockers Acebutolol, Labetalol, Pindolol Propranolol.
This action is the result of typical local anesthetic blockade of sodium channels and can be demonstrated experimentally in isolated neurons, heart muscle, and skeletal muscle membrane.
Which of the following antihypertensive drugs should not be used in a patient on Lithium in order to prevent Lithium Toxicity?
1) Clonidine
2) Beta blockers
3) Calcium Channel Blockers
4) Diuretics
Pharmacology Answer: 4
Diuretics increase sodium loss in urine and increase lithium retention. Hence they should not be used in patients on Lithium.