MDS PREP
Permanent auditory nerve deafness is frequently associated with use of
1. tetracycline
2. penicillin
3. bacitracin
4. streptomycin
Pharmacology
Answer: 4
Permanent auditory nerve deafness is frequently associated with use of streptomycin
Drug class causing free water clearance:
a) Diuretic
b) Saluretic
c) Uricosuric
d) Aquaretic
Pharmacology Answer: 4
Vasopressin antagonists like tolvaptan are aquaretics
Which of the following is not a loop diuretic:
1) Fruesmide
2) Torsemide
3) Ethacrynic acid
4) Chlorthalidone
Pharmacology Answer: 4
Chlorthalidone (Thiazide like diuretic)
Tyrosine kinase inhibitors are useful in the management of ?
1) Acute myeloid leukemia
2) Small cell carcinoma of lung
3) Gastrointestinal stromal tumors
4) Neurofibromatosis
Pharmacology Answer: 3
Tyrosine kinase inhibitors are used in the treatment of:
Chronic myeloid leukemia
Acute lymphoblastic leukemia ( philadelphia chromosome positive cases )
Head and neck malignancies
Non small cell carcinoma lung
Gastrointestinal stromal tumours
Hepatocellular cancer
Renal cell carcinoma
Pancreatic cancer
Colorectal cancer
Which of the following statement is not true about diuretics:
1) Acetazolamide is a carbonic acid anhydrase stimulant
2) Thiazides act on cortical diluting segment of loop of Henle
3) Frusemide is a high ceiling diuretic
4) Spironolactone is an aldosterone antagonist
Pharmacology Answer: 1
Acetazolamide is a carbonic acid anhydrase stimulant Acetazolamide, non-competitively (but reversibly) inhibits carbonic anhydrase in proximal tubular cells.
Which of the following fluoroquinolones does not require dose adjustment in a patient with creatinine clearance of < 50mg/min?
1) Ciprofloxacin
2) Trovafloxacin
3) Lomefloxacin
4) Sparfloxacin
Pharmacology Answer: 2
Fluoroquinolones that are excreted mainly by non renal mechanisms:
Pefloxacin Trovafloxacin Grepofloxacin Nalidixic acid
Local anaesthetic used as an antiarrhythmic agent is:
1) Bupivacaine
2) Lignocaine
3) Cocaine
4) Chlorprocaine
Pharmacology Answer: 2
It is also used to treat ventricular tachycardia and to perform nerve blocks
Dosage Of Local Anesthesia:
1) Safety dose of 2% Lignocaine is 4.5mg/kg without a Vasoconstrictor
Without a Vasoconstrictor 300 mg (maximum dose)
2) Safety dose of 2% Lignocaine is 7mg/kg with a Vasoconstrictor
With a Vasoconstrictor – 500 mg (maximum dose)
3) As 1ml of 2% Lignocaine contains 20mg – Where the Maximum safety dose being 300 mg
So 15 ml of Drug can be given safely
4) 1:1,00,000 concentration means 1 part of Adrenaline is 1,00,000 parts of Solution
Safety Dose of Adrenaline for Dental Use in normal patients is 0.2 mg – which means 20 ml of LA can be given to normal patients containing Adrenaline
For cardiac Patients the safety dose of Adrenaline is 0.04mg – Which means 4ml of LA can be given to Patients with cardiac problems containing Adrenaline
5) If the concentration of LA is 1:50,000 – 10 ml of LA can be given safely
Dry mouth during antidepressant therapy is caused by blockade of:
1) Muscarinic acetylcholine receptors.
2) Serotonergic receptors.
3) Dopaminergic receptors.
4) GABA receptors.
Pharmacology Answer: 1
Anticholinergic side effect of antidepressant leads to dry mouth in the patients on these drugs.
Dry mouth is due to the Muscarinic acetylcholine receptor antagonism of these drugs.