MDS PREP
Which of the following is associated with a low concentration of ionized calcium in the serum?
1. Hypothyroidism
2. Osteogenesis imperfecta
3. Paget"s disease of the bone
4. Tetany
Oral Pathology
Answer: 4
Tetany is associated with a low concentration of ionized calcium in the serum.
The odontoma which resembles anatomy of normal teeth is a
1) Composite odontoma
2) Compound odontoma
3) Complex odontoma
4) Complex compound odontoma
Oral Pathology
Answer: 2
Explanation: A compound odontoma is a type of odontogenic tumor that consists of multiple small tooth-like structures (denticles) and resembles the anatomy of normal teeth. In contrast, a complex odontoma has a more disorganized structure and does not resemble normal teeth.
Leucocytopenia is seen in
1. Influenza
2. Agranulocytosis
3. Liver cirrhosis
4. All of the above
Oral Pathology
Answer: 4
Leukocytopenia can be seen in influenza, agranulocytosis, and liver cirrhosis.
Nuclear cytoplasmic asynchrony is a characteristic feature of:
1. Megaloblastic anemia
2 Fe deficiency anemia
3. Erythroblastosis fetails
4. all of the above
Pathology
Answer: 1
Nuclear cytoplasmic asynchrony refers to a condition where the nucleus and
cytoplasm of a cell do not develop at the same rate. This can occur in various
forms of anemia and other pathological conditions. Here's a detailed explanation
of the concept and its relevance to the options provided:
1. Megaloblastic Anemia: Megaloblastic anemia is a type of anemia characterized
by the presence of large, immature, nucleated red blood cells (megaloblasts) in
the bone marrow and peripheral blood. This condition is primarily caused by a
deficiency in vitamin B12 or folic acid, which are essential for DNA synthesis
during cell division. The nucleus of the cells divides more slowly than the
cytoplasm, leading to an asynchronous development and the formation of large,
abnormal cells. In megaloblastic anemia, the nucleus is often large and
hyperchromatic (darkly stained), while the cytoplasm is relatively less
developed and pale. Therefore, this option is the most appropriate answer.
2. Fe Deficiency Anemia: Iron deficiency anemia is the most common type of
anemia worldwide, resulting from a lack of iron in the body. Iron is a critical
component of hemoglobin, which is responsible for carrying oxygen in red blood
cells. In this condition, the body produces smaller than normal red blood cells
(microcytic) that lack hemoglobin, leading to decreased oxygen transport. The
nucleus and cytoplasm of the erythrocytes are typically smaller than normal, and
there is no significant asynchrony in their development. Hence, this option is
not a characteristic feature of nuclear cytoplasmic asynchrony.
3. Erythroblastosis Fetalis: This is a condition that occurs when an Rh-negative
mother has an Rh-positive fetus. The mother's immune system produces antibodies
against the fetal red blood cells, leading to their destruction. This causes
anemia in the newborn. However, erythroblastosis fetalis is not typically
associated with nuclear cytoplasmic asynchrony. The anemia is a result of
hemolysis (destruction of red blood cells) rather than an intrinsic defect in
the development of the cells themselves. Thus, this option is not the correct
answer for this characteristic feature.
correct answer is:
1. Megaloblastic anemia
This is because megaloblastic anemia is the condition where nuclear cytoplasmic
asynchrony is a hallmark feature due to the disproportionate growth of the
nucleus and cytoplasm in red blood cell precursors, resulting from vitamin B12
or folic acid deficiencies affecting DNA synthesis.
Osmotic fragility is increased in -
1) Sickle cell anaemia
2) Thalassemia
3) Hereditary spherocytosis
4) Chronic lead poisoning
General Pathology
Answer: 3
Osmotic fragility is increased in hereditary spherocytosis due to the abnormal shape and membrane stability of red blood cells.
The first vascular reaction In Inflammation is:
1. Vasoconstriction
2.
Vasodilation
3. Increased vascular permeability
4. Marginisation or pavementing
Pathology Answer: 2
The first vascular reaction in inflammation is Vasodilation.
Explanation:
Inflammation is the body's protective response to tissue injury or infection. It
is characterized by the classical signs of redness (rubor), heat (calor),
swelling (tumor), pain (dolor), and loss of function (functio laesa). The
initial vascular changes in the inflammatory process include:
1. Vasoconstriction: This is a temporary response that occurs immediately after
injury to minimize blood loss. However, it is quickly followed by the more
significant and prolonged phase of vasodilation.
2. Vasodilation: This is the first major vascular reaction in the inflammatory
response. Vasodilation occurs due to the release of substances such as
histamine, bradykinins, and prostaglandins from the damaged tissue cells and
mast cells. These substances are known as vasodilators and they cause the smooth
muscles surrounding the blood vessels to relax, leading to an increase in the
diameter of the blood vessels. This results in increased blood flow to the
injured area, which is essential for delivering white blood cells, nutrients,
and oxygen to the site of inflammation. The increased blood flow is what causes
the characteristic redness and heat of an inflamed area.
3. Increased vascular permeability: Although it is not the first vascular
reaction, increased vascular permeability is a critical component of the
inflammatory process. After vasodilation, the endothelial cells that line the
blood vessels become more permeable, allowing plasma and proteins to leak out of
the vessels into the surrounding tissue. This leads to the formation of an
exudate, which is the accumulation of fluid and proteins that makes up the
swelling (edema) seen in inflammation.
4. Marginisation or Pavementing: This is the process where neutrophils (a type
of white blood cell) move along the walls of blood vessels towards the site of
inflammation. It occurs later in the inflammatory response after the initial
vasodilation and increased vascular permeability. These cells then migrate
through the vessel walls into the tissue to combat pathogens and debris.
An abnormal resorption pattern in primary teeth, delayed eruption of permanent teeth and a large tongue are the features of
1. Addison"s disease
2. Hypothyroidism
3. Hyperthyroidism
4. Von-Recklinghausen disease
Oral Pathology
Answer: 2
Hypothyroidism is characterized by abnormal resorption patterns in primary teeth and delayed eruption of permanent teeth.
Reduced salivary flow following irradiation is dose dependent. At what dose does the flow reach essentially zero?
1. 4000 rads
2. 5000 rads
3. 6000 rads
4. 7000 rads
Oral Pathology
Answer: 3
Reduced salivary flow reaches essentially zero at a dose of 6000 rads.