MDS PREP
Sickle cell trait patient do not have manifestations as that of Sickle cell disease, because-
1) 50% HbS is required for occurrence of sickling
2) HbA prevents sickling
3) 50% sickles
4) HbA prevents polymerization of Hbs
General Pathology
Answer: 1
HbA prevents sickling in sickle cell trait patients because the presence of normal hemoglobin (HbA) reduces the proportion of HbS, preventing polymerization.