MDS PREP
Heterozygous sickle cell anemia gives protection against -
1) G6PD
2) Malaria
3) Thalassemia
4) Dengue fever
General Pathology
Answer: 2
Heterozygous sickle cell anemia provides protection against malaria due to the altered red blood cell environment that is less hospitable to the malaria parasite.
Defect leading to thalassemia lies in -
1) Haemoglobin
2) Osmotic fragility
3) RBC membrane
4) Platelets
General Pathology
Answer: 1
The defect leading to thalassemia lies in the hemoglobin itself, specifically in the globin chain synthesis.
Which of the following statements about Addison's disease is correct?
1) Addison's disease is caused by excessive secretion of cortisol from the adrenal cortex.
2) Hyperpigmentation is not a classic physical finding in Addison's disease.
3) The mosaic pattern of bone is a characteristic of Addison's disease.
4) Increased incidence of astrocytomas is associated with Addison's disease.
Hyperpigmentation is a classic physical finding in Addison's disease, which is caused by adrenal insufficiency.
Trigeminal neuralgia
1. Does not disturb the patient during sleep
2. Can be treated with NSAIDs
3. Always bilateral in distribution
4. Is a hereditary condition
Oral Pathology
Answer: 1
Trigeminal neuralgia does not disturb the patient during sleep.
Which of the following is true regarding seminoma?
1) 40% cases occur in children <1 year of age
2) Alpha fetoprotein can be used as a marker
3) Dysgerminoma is its ovarian counterpart
4) All of the above statements are true
General Pathology Answer: 3Dysgerminoma is the ovarian counterpart of seminoma, which is a germ cell tumor found in the testes.
Which of the following may be a feature of acromegaly?
1. Large tongue
2. Micrognathia
3. Hypoglycaemia
4. Crowded teeth
Oral Pathology
Answer: 1
A large tongue is a common feature of acromegaly.
The primary defect which leads to sickle cell anemia is -
1) An abnormality in porphyrin part of hemoglobin
2) Replacement of glutamate by valine in ?-chain of HbA
3) A nonsense mutation in the ?-chain of HbA
4) Substitution of valine by glutamate in the ?-chain of HbA
General Pathology
Answer: 2
The primary defect in sickle cell anemia is the replacement of glutamic acid by valine in the ?-chain of hemoglobin, leading to the sickling of red blood cells.
True about Sickle cell anemia except -
1) Commonly seen in black
2) R.B.C. size is altered
3) Valine for Glutamic acid in ?-chain globin
4) Deletion of gene
General Pathology
Answer: 4
Deletion of a gene is not true about sickle cell anemia; it is caused by a point mutation, not a deletion.