MDS PREP
Necrotising ragged ulceration with no apparent inflammatory responses is indicative of
1. Leucocytosis
2. Polycythaemia vera
3. Sickle cell anaemia
4. Agranulocytosis
Oral Pathology
Answer: 4
Necrotizing ragged ulceration with no apparent inflammatory response is indicative of agranulocytosis.
Commonest type of Basal cell carcinoma is -
1. Ulcerated
2. Cystic
3. Morphoeic
4. Pigmented
Pathology
Answer: 1
1. Noduloulcerative Basal Cell Carcinoma: This is the most common subtype of
BCC, making up about 60-70% of all cases. It typically appears as a slowly
growing, round to oval, pearly or translucent nodule with a central ulceration
that may bleed or ooze. The borders of the lesion are often not well-defined and
may have a rolled, pearly edge with telangiectasias (small, dilated blood
vessels).
2. Cystic Basal Cell Carcinoma: This subtype presents as a round, dome-shaped
lesion with a cystic or fluid-filled center. It is less common than the
noduloulcerative type, and it may be mistaken for a benign cyst or epidermoid
cyst.
3. Morphoeic Basal Cell Carcinoma: Also known as sclerosing or morpheaform BCC,
this type is characterized by a slowly growing, ill-defined, firm, plaque-like
lesion that can infiltrate deeply into the skin. It may have a whitish, waxy
appearance with a scar-like texture. Morphoeic BCC tends to be more aggressive
and can be challenging to diagnose due to its subtlety.
4. Pigmented Basal Cell Carcinoma: This is a less common variant of BCC,
accounting for approximately 6-15% of cases. It presents with pigmentation in
the lesion, which can be brown, blue, or black. The presence of pigment can make
it look similar to melanoma, another type of skin cancer, so a biopsy is often
necessary to confirm the diagnosis.
Precancerous potential in Plummer-Vinson syndrome may be due to change in the epithelium like
1. Atrophy
2. Hypertrophy
3. Acanthosia
4. All the above
Oral Pathology
Answer: 1
Plummer-Vinson syndrome is associated with atrophic changes in the
epithelium, which can lead to an increased risk of cancer
Plummer-Vinson syndrome is characterized by a classic triad of
clinical features: dysphagia (difficulty swallowing), iron-deficiency anemia,
and esophageal webs. Additional symptoms may include glossitis (inflammation of
the tongue), koilonychia (spoon-shaped nails), and cheilitis (inflammation of
the lips).
Clinical Features of Plummer-Vinson Syndrome:
Dysphagia:
Difficulty swallowing due to the presence of esophageal webs, which
can obstruct the esophagus.
Iron-Deficiency Anemia:
Resulting from chronic blood loss or malabsorption, leading to
fatigue and weakness.
Esophageal Webs:
Thin membranes that form in the esophagus, contributing to
swallowing difficulties.
Glossitis:
Inflammation of the tongue, which may appear smooth and swollen.
Koilonychia:
Spoon-shaped nails that can indicate iron deficiency.
Cheilitis:
Inflammation and cracking of the lips, often associated with
nutritional deficiencies.
Fatigue and Weakness:
Common symptoms due to anemia and nutritional deficiencies.
Associated Risks:
Esophageal Cancer:
There is an increased risk of developing esophageal cancer in
individuals with Plummer-Vinson syndrome.
Prevention:
Iron Intake:
Ensuring adequate dietary iron may help prevent the onset of this
syndrome. Diagnosis and Management:
Diagnosis:
Diagnosis is typically made through clinical evaluation, endoscopy,
and imaging studies to identify esophageal webs and assess for anemia.
Management:
Treatment often involves iron supplementation to address anemia and
dietary modifications to improve iron intake. In some cases, dilation of
esophageal webs may be necessary to alleviate dysphagia
If a woman 22 weeks pregnant has ankle edema and proteinuria, the presence of which of the following would determine if she has preeclampsia?
1) Diabetes mellitus
2) Hyperuricemia
3) Hypertension
4) Systemic lupus erythematosus
Hypertension is a key factor in diagnosing preeclampsia in a pregnant woman with ankle edema and proteinuria.
Which of the following people are more susceptibe to UV light induced
carcinogenesis?
1. People with xeroderma pigmentosa
2. Fanconis anemia
3. Telangiectasia
4. All of the above
Pathology Answer: 4
1. People with Xeroderma Pigmentosum (XP):
Xeroderma pigmentosum is a rare genetic disorder that affects the way the skin
and eyes repair damage from UV radiation. Individuals with XP have a deficiency
in the DNA repair mechanism that normally removes UV-induced lesions. As a
result, their cells are more prone to mutations, which can lead to skin cancer.
There are several types of XP, and they vary in severity, but all are
characterized by extreme sensitivity to UV light, leading to early aging of the
skin, pigmentation changes, and a high risk of developing multiple skin cancers,
including melanoma, at a very young age.
2. Fanconi Anemia:
Fanconi anemia is another genetic disorder that affects the body's ability to
repair DNA. It is not exclusively related to UV radiation but rather to a defect
in the repair of DNA crosslinks, which can be caused by various agents,
including UV light. Patients with Fanconi anemia have an increased
susceptibility to various cancers, including skin cancers. Their cells have a
higher frequency of chromosomal instability and DNA damage, which can be
exacerbated by UV exposure. However, it's essential to note that the primary
cancer risk in Fanconi anemia is related to the underlying defect in DNA repair
and not solely to UV light.
3. Telangiectasia:
Telangiectasia is a condition where small blood vessels, especially those in the
skin, widen and become visible. While telangiectasia itself does not increase
the risk of skin cancer, individuals with certain forms of this condition may
have a higher susceptibility to UV light damage. For example, some patients with
telangiectasia may also have a genetic mutation or an acquired defect in the
skin that results in poor repair of UV-induced DNA damage. This can lead to a
higher risk of developing non-melanoma skin cancers like basal cell carcinoma
and squamous cell carcinoma. Moreover, telangiectasias are often found in areas
of the skin that have been exposed to significant UV radiation, such as the
face, neck, and hands, which are common sites for these types of skin cancers.
In summary, all of the conditions mentioned (Xeroderma Pigmentosum, Fanconi
Anemia, and Telangiectasia) can increase the susceptibility to UV light-induced
carcinogenesis due to their respective impairments in DNA repair mechanisms and
skin responses to UV radiation.
Oral lesions on the tongue and other mucosal surfaces of the oral cavity is commonly caused by the deficiency of
1. Vit B
2. Niacin
3. Vit C
4. Vit K
Oral Pathology
Answer: 2
Oral lesions on the tongue are commonly caused by a deficiency of Niacin (Vitamin B3).
A bacterial disease with oral manifestations is
1) Herpes Measles
2) Measles
3) Diphtheria
4) Leishmaniasis
Oral Pathology
Answer: 3
Diphtheria serious bacterial infection that usually affects the mucous
membranes of the nose and throat.
Diphtheria signs and symptoms usually begin 2 to 5 days after a person becomes
infected. Signs and symptoms may include:
A thick, gray membrane covering the throat and tonsils
A sore throat and hoarseness
Swollen glands (enlarged lymph nodes) in the neck
Difficulty breathing or rapid breathing
Nasal discharge
Fever and chills
Tiredness
Skin (cutaneous) diphtheria
A second type of diphtheria can affect the skin, causing pain, redness and
swelling similar to other bacterial skin infections. Ulcers covered by a gray
membrane also may be a sign of skin diphtheria.
The residual biologic damage tha remains following an exposure to radiation is called
1. Direct effect
2. Indirect effect
3. Cumulative effect
4. Tolerance
Oral Pathology
Answer: 3
The residual biological damage that remains following exposure to radiation is called cumulative effect.