MDS PREP
Agranulocytosis may involve early lesions of the oral mucosa and the gingiva that are non-spcific but resemble
1. Erythematous stomatitis
2. Acute herpetic stomatitis
3. Necrotizing ulcerating gingivitis
4. Non specific vesiculobullous stomatitis
Oral Pathology
Answer: 3
Agranulocytosis may resemble necrotizing ulcerative gingivitis.
Which of the following complement component can be activated in both common as well as alternate pathways?
1) C1
2) C2
3) C3
4) C4
General Pathology Answer: 3C3 is the complement component that can be activated in both the classical and alternative pathways of the complement system.
All of the following statements about idiopathic thrombocytopenic purpura are true except
1. It is associated with platelet-specific autoantibodies
2. It causes a prolonged bleeding time
3. It is often controllable by immunosuppressive treatment
4. It causes more prolonged haemorrhage than haemophilia
Oral Pathology Answer: 4
It is associated with platelet-specific autoantibodies:
This statement is true. ITP is characterized by the
presence of autoantibodies that specifically target and destroy platelets,
leading to thrombocytopenia (low platelet count).
It causes a prolonged bleeding time: This statement is true.
In ITP, the low platelet count results in a prolonged bleeding time, as
there are fewer platelets available to form a clot.
It is often controllable by immunosuppressive treatment:
This statement is true. ITP can often be managed with
immunosuppressive therapies, such as corticosteroids, intravenous
immunoglobulin (IVIG), or other immunosuppressive agents, to help increase
platelet counts.
It causes more prolonged hemorrhage than hemophilia:
This statement is not true. While both ITP and hemophilia
can lead to bleeding, the mechanisms are different. Hemophilia is a clotting
factor deficiency, which can lead to more severe and prolonged bleeding
episodes, especially after trauma or surgery. In contrast, ITP primarily
affects the number of platelets rather than the clotting factors. Therefore,
the bleeding in hemophilia can be more severe and prolonged compared to that
in ITP.
Which of the following tumors is most aggressive
1) Myxoma
2) Cementoblastoma
3) Ameloblastic fibroma
4) Ameloblastic fibro-odontoma
Oral Pathology
Answer: 1
Myxoma is the most aggressive tumor among the options listed. It is a rare,
benign, but locally aggressive neoplasm that can occur in various anatomic
locations, particularly in the heart and skin. Myxomas are known for their
ability to invade surrounding tissue and cause significant damage to the organ
in which they are found.
Here is a brief description of each tumor type:
1) Myxoma: As mentioned earlier, these are rare but locally
aggressive tumors that can invade and destroy surrounding tissues. They are
typically soft and gelatinous in consistency. When myxomas occur in the heart,
they can obstruct blood flow and cause severe complications.
2) Cementoblastoma: This is a rare, benign tumor that arises
from the periodontal ligament cells that are responsible for producing cementum,
which is the bone-like tissue that anchors teeth in the jaw. Cementoblastomas
are generally slow-growing and less aggressive compared to myxomas.
3) Ameloblastic fibroma: This is a benign, non-invasive tumor
that occurs in the jaw, typically in younger patients. It is composed of both
odontogenic epithelial cells and mesenchymal cells, which are involved in tooth
development. These tumors can cause expansion of the bone but are not as
aggressive as myxomas.
4) Ameloblastic fibro-odontoma: This is a mixed odontogenic
tumor, which means it is composed of both dental epithelial and mesenchymal
cells. It is usually benign and presents as a slowly growing, painless swelling
in the jaw. While it can cause bone expansion, it is less aggressive and
typically does not invade surrounding tissues like a myxoma.
An undifferentiated malignant tumor on immunohistochemical stain shows cytoplasmic positivity of most of the tumor cells for cytokeratin. The most probable diagnosis of the tumor is:
1) Sarcoma
2) Lymphoma
3) Carcinoma
4) Malignant melanoma
General Pathology Answer: 3Cytokeratin positivity in an undifferentiated malignant tumor suggests that the tumor is likely a carcinoma, as cytokeratins are markers for epithelial cells.
Letterer-Siwe disease is a disturbance of
1) Protein metabolism
2) Lipid metabolism
3) Mucopolysaccharide metabolism
4) Carbohydrate metabolism
Oral Pathology
Answer: 2
Letterer-Siwe disease is a type of Langerhans cell histiocytosis that is associated with disturbances in lipid metabolism.
Letterer-Siwe disease is a form of Langerhans cell
histiocytosis (LCH), which is characterized by the proliferation of
Langerhans cells, a type of dendritic cell involved in immune response. This
disease primarily affects children and can present with a variety of symptoms,
including:
Bone Lesions: Osteolytic bone lesions, particularly in
the skull, vertebrae, and long bones.
Skin Rash: Erythematous lesions or seborrheic
dermatitis-like rashes.
Hematological Abnormalities: Anemia, thrombocytopenia,
and leukopenia may occur.
Organ Involvement: It can affect multiple organs,
including the liver, spleen, and lungs.
Metabolic Disturbance:
Lipid Metabolism: Letterer-Siwe disease is associated
with disturbances in lipid metabolism, particularly due to the accumulation
of lipids in the affected tissues. The Langerhans cells in this condition
can exhibit abnormal lipid storage, which is a hallmark of the disease.
Extensive cellulitis is known as:
1. Phlegm
2. Phlegmon
3. Cellulitis majora
4. Cellulitis prima
Pathology Answer: 2
Extensive cellulitis is most accurately described by the term "phlegmon
Phlegm is a thick, viscous substance produced by the respiratory tract,
especially during a respiratory infection, which can be coughed up from the
lungs or expelled from the nose. It is primarily composed of mucus, dead cells,
and other substances.
Phlegmon is a term that is closely related to extensive cellulitis. It refers
to a severe form of cellulitis where the infection has spread deeply into the
subcutaneous tissues and is accompanied by significant inflammation, including
the presence of pus and necrosis. Phlegmon is characterized by intense pain,
swelling, redness, and warmth in the affected area. This condition often
requires aggressive medical management, including intravenous antibiotics and
surgical drainage if an abscess forms. It is an advanced and severe stage of
cellulitis that can lead to systemic infection if not treated properly.
The main purpose of intensifying screens in extraoral radiographic films is
1. To increase the contrast of film
2. To increase the exposure time
3. To decrease the speed of film
4. Decrease secondary radiation to patient
Oral Pathology
Answer: 4
The main purpose of intensifying screens is to decrease secondary radiation to the patient.