MDS PREP
What is the primary mechanism of action of amphotericin B in treating systemic fungal infections?
(1) Inhibition of fungal cell wall synthesis
(2) Inhibition of fungal DNA replication
(3) Inhibition of fungal protein synthesis
(4) Alteration of fungal membrane potential
Amphotericin B is an antifungal agent that works primarily by binding to ergosterol in the fungal cell membrane, leading to increased permeability and cell death. It is effective against a wide range of fungi and is often used to treat severe systemic infections.
Condition not associated with primary inflammation
1. Pregnancy
2. Dilantin therapy
3. Vit-C deficiency
4. Puberty
Oral Medicine
Answer: 2
Malherbe"s epithelioma characterised by all except
1) Benign calcifying epithelioma
2) Common in adults
3) Solitary, hard tumours
4) Mostly on the neck, face, arms
Oral medicine
Answer: 2
Malherbe's epithelioma, also known as calcifying epithelioma, is typically a benign tumor that is more common in children and young adults rather than adults. It is characterized by solitary, hard tumors that are often found on the neck, face, and arms. The other options accurately describe the characteristics of Malherbe's epithelioma.
What is the typical age of onset for the increased risk of coronary heart disease in men?
1) ? 45 years
2) ? 55 years
3) ? 65 years
4) ? 75 years
Men generally have an earlier onset of coronary heart disease compared to women, and the risk increases significantly after the age of 45.
A patient with known hypertension is started on clonidine therapy. Which of the following is a potential side effect of this medication?
(1) Increased heart rate
(2) Peripheral edema
(3) Sexual dysfunction
(4) Diarrhea
Clonidine is a centrally acting antihypertensive that reduces blood pressure by decreasing sympathetic outflow. It can sometimes cause bradycardia rather than increased heart rate. Other common side effects include dry mouth, dizziness, and sedation.
What is the primary defect in familial hypokalemic periodic paralysis?
1) Marked increase in muscle potassium permeability
2) Marked decrease in muscle sodium permeability
3) Marked decrease in muscle potassium permeability
4) Impaired sodium-potassium pump function
In familial hypokalemic periodic paralysis, the primary defect is a decrease in muscle potassium permeability, leading to a reduced efflux of potassium from muscle cells.
Which of the following is NOT a common symptom of valvular heart disease?
1) Shortness of breath
2) Rapid heartbeat
3) Chest discomfort
4) Abnormal body temperature
Valvular heart disease symptoms typically include weakness on exertion, rapid heartbeat, chest discomfort, and fainting spells. However, an abnormal body temperature is not a common symptom associated with valvular heart disease.
What is the role of tissue plasminogen activator (tPA) in the treatment of pulmonary embolism?
1) Prevents thrombus formation
2) Dissolves existing thrombi
3) Inhibits platelet aggregation
4) Enhances fibrinolysis
tPA is a thrombolytic agent used to dissolve blood clots. In the treatment of pulmonary embolism, it is administered to break down the clot in the pulmonary artery, thereby improving blood flow and reducing the risk of complications.