Leakage due to improper obturation: Inadequate sealing of the root canal system allows bacteria and irritants to leak from the oral cavity back into the periapical tissues, causing the lesion to persist or enlarge.
Persistent cystic lining: A true cyst has a distinct epithelial lining that is not resolved by conventional non-surgical root canal therapy alone. If the cyst lining remains, the lesion may continue to grow.
Failure to do apical curettage: While not always necessary for non-surgical cases, in some instances where the lesion is large or persistent, surgical intervention including apical curettage (removal of the inflamed or infected periapical tissue) may be required to facilitate healing.