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Showing page 1 of 32 (282 total shorts) — subject: "Pathology"
#1 Pathology
Thrombocytopenia is not a feature of intravascular hemolysis; it is more commonly associated with other conditions such as bone marrow disorders.
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Answer
All are features of Intravascular hemolysis except -
1) Thrombocytopenia
2) Hemosiderinuria
3) Decreased haptoglobin
4) Raised indirect bilirubin
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#2 Pathology
HbA prevents sickling in sickle cell trait patients because the presence of normal hemoglobin (HbA) reduces the proportion of HbS, preventing polymerization.
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Sickle cell trait patient do not have manifestations as that of Sickle cell disease, because-
1) 50% HbS is required for occurrence of sickling
2) HbA prevents sickling
3) 50% sickles
4) HbA prevents polymerization of Hbs
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#3 Pathology

EBV tumor list: Burkitt lymphoma, B-cell lymphomas in immunodeficient (HIV, post-transplant), subset of Hodgkin lymphoma (mixed cellularity), nasopharyngeal carcinoma (100% non-keratinizing), subset of T-cell lymphomas, NK cell lymphomas, gastric carcinomas (?10%), and rarely sarcomas in immunosuppressed. Hepatocellular carcinoma associated with HBV, HCV, not EBV.

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Answer

EBV is associated with all EXCEPT:
1) Nasopharyngeal carcinoma
2) Subset of Hodgkin lymphoma
3) Gastric carcinoma subset
4) Hepatocellular carcinoma

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#4 Pathology

Correct answer: B) Langhans' giant cells, seen in tuberculosis and sarcoidosis, have nuclei arranged peripherally in a horseshoe or ring pattern (or clustered at the poles). Foreign body giant cells have randomly scattered nuclei; Touton giant cells have a vacuolated lipid-laden rim (as in xanthoma); Aschoff giant cells derive from cardiac histiocytes in rheumatic nodules.

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Giant cells with nuclei arranged in a horseshoe or peripheral ring pattern, classically seen in tuberculosis, are called:
1) Foreign body giant cells
2) Langhans' giant cells
3) Touton giant cells
4) Aschoff giant cells

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#5 Pathology

Correct answer: C) FFP is used for coagulation factor deficiencies when specific factor concentrates are unavailable or inappropriate — such as warfarin reversal, vitamin K deficiency, antithrombin III deficiency, or after massive transfusion. When a specific concentrate is available (as for isolated factor VIII deficiency), FFP is not the preferred choice.

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Answer

Fresh frozen plasma (FFP) is indicated in all of the following EXCEPT:
1) Emergency reversal of warfarin effect
2) Vitamin K deficiency with deficient factors II, VII, IX, X
3) Isolated factor VIII deficiency when specific concentrate is available
4) Antithrombin III deficiency

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#6 Pathology
Hyperpigmentation is a classic physical finding in Addison's disease, which is caused by adrenal insufficiency.
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Answer

Which of the following statements about Addison's disease is correct?
1) Addison's disease is caused by excessive secretion of cortisol from the adrenal cortex.
2) Hyperpigmentation is not a classic physical finding in Addison's disease.
3) The mosaic pattern of bone is a characteristic of Addison's disease.
4) Increased incidence of astrocytomas is associated with Addison's disease.

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#7 Pathology
Hashimoto's thyroiditis is the most common cause of hypothyroidism in adults leading to myxedema.
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Which of the following is the most common cause of hypothyroidism in adults leading to myxedema?
1) Cretinism
2) Grave's disease
3) Hyperthyroidism
4) Hashimoto's thyroiditis

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#8 Pathology

Correct answer: B) These opaque, white, fibrous pericardial plaques, believed to result from healing of prior pericarditis, are seen most often on the anterior right ventricular surface — historically noted in WWI soldiers whose shoulder-bag straps caused chronic pericardial irritation.

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Pericardial "milk spots" or "soldiers' spots" are most frequently found on which surface?
1) Posterior surface of left atrium
2) Anterior surface of right ventricle
3) Diaphragmatic surface of left ventricle
4) Visceral pericardium over the aorta

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#9 Pathology
Tay-Sachs disease is characterized by a deficiency of hexosaminidase A, leading to neurodegeneration, mental retardation, and blindness in affected infants.
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What is the most likely diagnosis in an 8-month-old child with mental retardation, blindness, and muscle weakness, with a deficiency of hexosaminidase ?-subunit?
1) Tay-Sachs disease
2) Krabbe disease
3) Sandhoff disease
4) Gaucher disease
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