MDS PREP
All of the following drugs cross the placenta except?
1) Phenytoin
2) Diazepam
3) Morphine
4) Heparin
Pharmacology Answer: 4
Heparin Heparin does not the cross the placenta.
Hence its safe for use in pregnant patients who need anticoagulation.
Chelating agent contraindicated in iron and cadmium poisoning
1) Penicillamine
2) Des ferroxamine
3) EDTA
4) BAL
Pharmacology Answer: 4
Dimercaprol (British antilewisite; BAL)
1. Poisoning by As, Hg, Au, Bi, Ni, Sb: it is administered i.m., 5 mg/kg stat, followed by 2-3 mg/kg every 4 – 8 hours for 2 days, then once or twice a day for 10 days. It is partly oxidized and glucuronide conjugated, but mainly excreted as such in 4 – 6 hours. Earlier the treatment is instituted, the better it is. Because the dimercaprolmetal complex dissociates faster in acidic urine and the released metal can damage the kidney, urine is alkalinized during dimercaprol therapy.
2. As an adjuvant to Cal. Disod. Edentate in lead poisoning.
3. As an adjuvant to penicillamine in Cu poisoning and in Wilson’s disease – 300 mg/day i.m. for 10 days every second month.
It is contraindicated in iron and cadmium poisoning, because the dimercaprol-Fe and dimercaprol-Cd complex is itself toxic.
Drug used in acute gout is?
1) Aspirin
2) Indomethacin
3) Phenylbutazone
4) Allopurinol
Pharmacology Answer: 4
Treatment of acute gout is mainly to control symptoms, i.e. pain, swelling etc.
The symptoms of acute gout are due to inflammation in the joints.
So, drugs which decrease inflammation are used in acute gout, i.e. anti-inflammatory drugs. Drugs are:- NSAIDs, Colchicine, Corticosteroids
Not a contraindication for epinephrine use is
1) Heart disease.
2) Hypersensitivity to drug.
3) Hyperthyroidism.
4) Liver disease.
Pharmacology Answer: 4
Adrenaline is contraindicated in hypertensive, hyperthyroid and angina patient.
Hypersensitivity to drug is absolute contraindication to any drug.
Which of the following statements is not true regarding sulfonamides:
1) Sulfasalazine is absorbed well from GIT
2) Crystalluria can occur with sulfonamide administration
3) Sulfonamide administration to Newborn may cause Kernicterus
4) Sulfonamides are of value in treatment of infections due to Norcardia species
Pharmacology Answer: 1
Sulfasalazine is absorbed well from GIT
Sulfasalazine is poorly absorbed (10-20%) from the GIT .
Morphine withdrawal is characterized by all except
1) Miosis
2) Yawning
3) Lacrimation
4) Diarrhea
Pharmacology Answer: 1
Withdrawal of morphine is associated with marked drug-seeking behavior.
Physical manifestations of abstinence are - lacrimation, sweating, yawning, anxiety, fear, restlessness, gooseflesh, mydriasis, tremor, insomnia, abdominal colic, diarrhea, dehydration, rise in BP, palpitation and rapid weight loss.
Delirium and convulsions are not a characteristic feature (contrast barbiturates) and are seen only occasionally.
Cardi-ovascular collapse and fatality are rare if supportive measures are instituted.
Which of the following fluoroquinolones does not require dose adjustment in a patient with creatinine clearance of < 50mg/min?
1) Ciprofloxacin
2) Trovafloxacin
3) Lomefloxacin
4) Sparfloxacin
Pharmacology Answer: 2
Fluoroquinolones that are excreted mainly by non renal mechanisms:
Pefloxacin Trovafloxacin Grepofloxacin Nalidixic acid
A medication that reduces the rate of aqueous humor formation in acute glaucoma
1) phenothiazines
2) amphotericin B
3) Isoniazid
4) carbonic anhydrase inhibitors
Pharmacology Answer: 4
Carbonic anhydrase is found in erythrocytes, kidney, gut, ciliary body, choroid plexus, and glial cells.
Carbonic anhydrase inhibitors are used primarily as probes for studying renal transport mechanisms and in the treatment of glaucoma
When used to treat glaucoma, carbonic anhydrase inhibitors diminish the transport of HCO3 - and Na+ by the ciliary process, which limits intraocular pressure.
This reduces the formation of aqueous humor by up to 50%, thereby reducing the intraocular pressure. These agents can also limit CSF and endolymph formation.