MDS PREP
The primary agent used in the treatment of trigeminal neuralgia is
1. diazepam
2. phenytoin
3. phenobarbital
4. carbamazepine
Pharmacology
Answer: 4
carbamazepine is the primary agent used in
ment of trigeminal neuralgia
A dental patient on clonidine therapy for hypertension most often complains of
1) Xerostomia
2) Frequent visit to the bathroom
3) Restlessness
4) Postural hypertension
Pharmacology Answer: 1
Clonidine cause significant CNS depression and xerostomia
Which drug is most effective in reducing mortality in patients with left ventricular systolic dysfunction ?
1) Enalapril
2) Aspirin
3) Digoxin
4) Frusemide
Pharmacology Answer: 1
ACE inhibition has a beneficial impact on survival rates, functional status, and hemodynamics in patients with left ventricular systolic dysfunction.
In the renin-angiotensin system, a fall in perfusion pressure stimulates the juxtaglomerular cells in the kidney to release the enzyme renin.
Renin cleaves the decapeptide angiotensin I from angiotensinogen, a glycoprotein synthesized in the liver.
The octapeptide angiotensin II is formed by the action of ACE on angiotensin I.
Angiotensin II is a potent vasoconstrictor and stimulates the release of aldosterone and norepinephrine.
Which of the following are anti-fungal drugs?
1) Cloxacillin
2) Aciclovir
3) Chlorhexidine
4) Nystatin
Pharmacology Answer: 4
Miconazole is an imidazole anti-fungal drug, Nystatin is a polyene anti-fungal drug and itraconazole is a triazole anti-fungal.
Aciclovir is an anti-viral drug and chlorhexidine is an antiseptic.cloxacillin is penicillin derivative.
Dopamine is preferred in treatment of shock because of
1) Renal Vasodilatory effect
2) Increased Cardiac Output
3) Peripheral Vasoconstriction
4) Prolonged action
Pharmacology Answer: 1
Dopamine as a first line of drug in patients with shock
Dopamine in low doses can dilate renal vasculature therefore maintaining glomerular filtration.
Activates adenylate cyclase - cAMP – relaxation of vascular smooth muscle
Which of the following is the first drug to be prescribed in status asthmaticus?
1) Salbutamol
2) Humidified oxygen inhalation
3) Hydrocortisone hemisuccinate
4) Sodium bicarbonate infusion
Pharmacology Answer: 3
Status asthmaticus/Refractory asthma
Any patient of asthma is susceptible to develop acute severe asthma which may be life-threatening. Upper respiratory tract infection is the most common precipitant.
(i) Hydrocortisone hemisuccinate 100 mg (or equivalent dose of another glucocorticoid) i.v. stat, followed by 100-200 mg 4-8 hourly infusion; may take upto 6 hours to act.
(ii) Nebulized salbutamol (2.5-5 mg) + ipratropium bromide (0.5 mg) intermittent inhalations driven by O2 .
(iii) High flow humidified oxygen inhalation
(iv) Salbutamol/terbutaline 0.4 mg i.m./s.c. may be added since inhaled drug might not get to smaller bronchi owing to severe narrowing/plugging with secretions
(v) Intubation and mechanical ventilation if needed
(vi) intensive antibiotic therapy to be used for treating chest infection
(vii) Treat dehydration and acidosis with saline + sod. Bicarbonate/lactate infusion.
Which of the following is a Beta-1 selective blocker ?
1) propranolol
2) nadolol
3) pindolol
4) betaxolol
Pharmacology Answer: 4
Beta-1 selective blockers
These include atenolol and metoprolol (as well as betaxolol, bevantolol, and perhaps esmolol).
Non-selective beta blockers
propranolol
The antibiotic of choice in acute epiglottitis culture sensitivity report is -
1. Erythromycin
2. Rolitetracycline
3. Doxycycline
4. Ampicillin
Pharmacology
Answer: 4
Ampicillin is the antibiotic of choice for acute epiglottitis based on culture sensitivity.