MDS PREP
The penicillin with the best gram negative spectrum is
1. methicillin
2. phenethicillin
3. ampicillin
4. penicillin V
Pharmacology
Answer: 3
The penicillin with the best gram negative spectrum is ampicillin
The Beta Blocker with local Anesthetic effect is
1) Pindolol
2) Atenolol
3) Esmorolol
4) Timolol
Pharmacology Answer: 1
Local anesthetic action, also known as "membrane-stabilizing" action, is a prominent effect of several -blockers Acebutolol, Labetalol, Pindolol Propranolol.
This action is the result of typical local anesthetic blockade of sodium channels and can be demonstrated experimentally in isolated neurons, heart muscle, and skeletal muscle membrane.
All of the following statements are true regarding the cephalosporin
antibiotics except
1). they are bactericidal
2). they are ineffective against gram negative microorganisms
3). they are potentially cross allergenic with penicillin
4). they are resistant to penicillinase
Pharmacology Answer: 2
cephalosporin are bactericidal, are potentially cross allergenic with penicillin, resistant to penicillinase
Which drug is most effective in reducing mortality in patients with left ventricular systolic dysfunction ?
1) Enalapril
2) Aspirin
3) Digoxin
4) Frusemide
Pharmacology Answer: 1
ACE inhibition has a beneficial impact on survival rates, functional status, and hemodynamics in patients with left ventricular systolic dysfunction.
In the renin-angiotensin system, a fall in perfusion pressure stimulates the juxtaglomerular cells in the kidney to release the enzyme renin.
Renin cleaves the decapeptide angiotensin I from angiotensinogen, a glycoprotein synthesized in the liver.
The octapeptide angiotensin II is formed by the action of ACE on angiotensin I.
Angiotensin II is a potent vasoconstrictor and stimulates the release of aldosterone and norepinephrine.
Which of the following Antimicrobials has Antipseudomonal action:
1) Cefopodoxime proxetil
2) Ceforanide
3) Cefotetan
4) Cefoperazone
Pharmacology Answer: 4
Cephalosporins with antipseudomonal action:
Cefoperazone Ceftazidime
Which of the following statements is not true regarding sulfonamides:
1) Sulfasalazine is absorbed well from GIT
2) Crystalluria can occur with sulfonamide administration
3) Sulfonamide administration to Newborn may cause Kernicterus
4) Sulfonamides are of value in treatment of infections due to Norcardia species
Pharmacology Answer: 1
Sulfasalazine is absorbed well from GIT
Sulfasalazine is poorly absorbed (10-20%) from the GIT .
In Dicumarol poisoning which Vit K is used
1) Menadione
2) Menaqunone
3) Phytonadione
4) None of the above
Pharmacology Answer: 3
To reverse the effect of overdose of oral anticoagulants:
Phytonadione (K1) is the preparation of choice, because it acts most rapidly, dose depends on the severity of upoprothrombinemia & bleeding.
Which of the following is used for the treatment of chlamydia infection in pregnancy?
1) Tetracycline
2) Erythromycin
3) Azithromycin
4) Doxycycline
Pharmacology Answer: 3
Azithromycin Preferred agent for treatment of chlamydia infection in pregnancy in azithromycin.
It is given as a single dose of 1g leading to high compliance rate.