MDS PREP
Which drug is most effective in reducing mortality in patients with left ventricular systolic dysfunction ?
1) Enalapril
2) Aspirin
3) Digoxin
4) Frusemide
Pharmacology Answer: 1
ACE inhibition has a beneficial impact on survival rates, functional status, and hemodynamics in patients with left ventricular systolic dysfunction.
In the renin-angiotensin system, a fall in perfusion pressure stimulates the juxtaglomerular cells in the kidney to release the enzyme renin.
Renin cleaves the decapeptide angiotensin I from angiotensinogen, a glycoprotein synthesized in the liver.
The octapeptide angiotensin II is formed by the action of ACE on angiotensin I.
Angiotensin II is a potent vasoconstrictor and stimulates the release of aldosterone and norepinephrine.
Ethohepatazine is a chemical derivative of
1. codeine
2. morphine
3. meperidine
4. papaverine
Pharmacology
Answer: 3
Ethohepatazine is a chemical derivative of meperidine
Tyrosine kinase inhibitors are useful in the management of ?
1) Acute myeloid leukemia
2) Small cell carcinoma of lung
3) Gastrointestinal stromal tumors
4) Neurofibromatosis
Pharmacology Answer: 3
Tyrosine kinase inhibitors are used in the treatment of:
Chronic myeloid leukemia
Acute lymphoblastic leukemia ( philadelphia chromosome positive cases )
Head and neck malignancies
Non small cell carcinoma lung
Gastrointestinal stromal tumours
Hepatocellular cancer
Renal cell carcinoma
Pancreatic cancer
Colorectal cancer
Not a contraindication for epinephrine use is
1) Heart disease.
2) Hypersensitivity to drug.
3) Hyperthyroidism.
4) Liver disease.
Pharmacology Answer: 4
Adrenaline is contraindicated in hypertensive, hyperthyroid and angina patient.
Hypersensitivity to drug is absolute contraindication to any drug.
Which of the following antiviral drugs cannot be given orally?
1) Zidovudine
2) Zalcitabine
3) Acyclovir
4) Iodoxuridine
Pharmacology Answer: 4
Idoxuridine acts as an antiviral agent against DNA viruses by inhibiting thymidilate phosphorylase and viral DNA polymerases.
The effect of Idoxuridine results in the inability of the virus to reproduce or to infect/destroy tissue.
This product is available in the following dosage forms:Solution and Ointment
The penicillin with the best gram negative spectrum is
1. methicillin
2. phenethicillin
3. ampicillin
4. penicillin V
Pharmacology
Answer: 3
The penicillin with the best gram negative spectrum is ampicillin
Ipratropium bromide is useful in bronchial asthma because of
1) Anticholinergic effect
2) Vasodilator properties
3) Antiallergic action
4) Stabilization of mast cells
Pharmacology Answer: 1
Ipratropium (as ipratropium bromide, trade name Atrovent) is an anticholinergic drug administered by inhalation for the treatment of obstructive lung diseases.
It acts by blocking muscarinic receptors in the lung, inhibiting bronchoconstriction and mucus secretion.
It is a non-selective muscarinic antagonist, and does not diffuse into the blood, which prevents systemic side effects.
Ipratropium is a derivative of atropine[1] but is a quaternary amine and therefore does not cross the blood-brain barrier
In Dicumarol poisoning which Vit K is used
1) Menadione
2) Menaqunone
3) Phytonadione
4) None of the above
Pharmacology Answer: 3
To reverse the effect of overdose of oral anticoagulants:
Phytonadione (K1) is the preparation of choice, because it acts most rapidly, dose depends on the severity of upoprothrombinemia & bleeding.