MDS PREP
Ipratropium bromide is useful in bronchial asthma because of
1) Anticholinergic effect
2) Vasodilator properties
3) Antiallergic action
4) Stabilization of mast cells
Pharmacology Answer: 1
Ipratropium (as ipratropium bromide, trade name Atrovent) is an anticholinergic drug administered by inhalation for the treatment of obstructive lung diseases.
It acts by blocking muscarinic receptors in the lung, inhibiting bronchoconstriction and mucus secretion.
It is a non-selective muscarinic antagonist, and does not diffuse into the blood, which prevents systemic side effects.
Ipratropium is a derivative of atropine[1] but is a quaternary amine and therefore does not cross the blood-brain barrier
Chlortetracycline acts by interfering with
1. protein synthesis on bacterial but not mammalian ribosomes
2. cell wall synthesis
3. nucleic acid synthesis
4. protein synthesis on mammalian but not bacterial ribosomes
Pharmacology
Answer: 1
Chlortetracycline acts by interfering with protein synthesis on bacterial but not mammalian ribosomes
Alkalinization of urine is done during administration of which of the following chemotherapeutic drugs?
1) Ara-C (Cytarabine)
2) Methotrexate
3) Cisplatin
4) Ifosfamide
Pharmacology Answer: 2
Alkalinization of urine is used in patients receiving high dose methotrexate to promote renal excretion and to avoid nephrotoxicity
IV Sodium bicarbonate is used to maintain urine pH above 7.0 to avoid precipitation of methotrexate (a weak acid) in the acid pH of renal tubules
A medication that is associated with gingivitis
1) phenytoin
2) carbamazepine
3) propranolol
4) diazepam
Pharmacology Answer: 1
Gingivitis is a form of periodontal disease. Periodontal disease is when inflammation and infection destroy the tissues that support the teeth, including the gingiva (gums), the periodontal ligaments, and the tooth sockets (alveolar bone Malocclusion of teeth (misaligned teeth), rough edges of fillings, and ill fitting or unclean mouth appliances (such as orthodontic appliances, dentures, bridges, and crowns) can irritate the gums and increase the risk of gingivitis.
Medications such as phenytoin and birth control pills, and ingestion of heavy metals such as lead and bismuth are also associated with gingivitis.
Ethosuximide is the drug of choice for treatment of ?
1) Generalized tonic clonic seizures
2) Absence seizures
3) Simple partial seizures
4) Complex partial seizures
Pharmacology Answer: 2
Ethosuximide is the drug of choice for treatment of absence seizures.
Other drugs used in the management of absence seizures are valproic acid, lamotrigine and clonazepam.
Metronidazole is a treatment of choice for :
1) Salmonellosis
2) Ulcerative colitis
3) hookworm parasitic infection
4) Pseudomembranous colitis
Pharmacology Answer: 4
metronidazole 250 mg po qid for 7 to 10 days is the treatment of choice.
Oral vancomycin 125 mg qid is reserved for the most severe or resistant cases
The antimicrobials most widely regarded as optimal for the treatment of salmonellosis in adults is the group of fluoroquinolones.
Current evidence indicates that endorphins are
1. endogenous molecules having morphine like properties
2. receptors located in the periaqueductal grey area of the brain Which are sensitive to opiates
3. large polypeptides that regulate renal activity
4. central nervous system transmitters implicated in depressive psychoses
Pharmacology
Answer: 1
endorphins are endogenous molecules having morphine like properties
A medication that may elicit headache as a side effect :
1) thiazide
2) Methyldopa
3) hydralazine
4) Procainamide
Pharmacology Answer: 3
A number of medications may elicit headache as a side effect.
Common offenders include nitroglycerin, hydralazine, calcium-channel blockers, digitalis, and estrogen.
Recreational drugs such as nicotine, alcohol, marijuana, and amphetamines can also induce headache.