MDS PREP
Drug class causing free water clearance:
a) Diuretic
b) Saluretic
c) Uricosuric
d) Aquaretic
Pharmacology Answer: 4
Vasopressin antagonists like tolvaptan are aquaretics
A medication that is associated with gingivitis
1) phenytoin
2) carbamazepine
3) propranolol
4) diazepam
Pharmacology Answer: 1
Gingivitis is a form of periodontal disease. Periodontal disease is when inflammation and infection destroy the tissues that support the teeth, including the gingiva (gums), the periodontal ligaments, and the tooth sockets (alveolar bone Malocclusion of teeth (misaligned teeth), rough edges of fillings, and ill fitting or unclean mouth appliances (such as orthodontic appliances, dentures, bridges, and crowns) can irritate the gums and increase the risk of gingivitis.
Medications such as phenytoin and birth control pills, and ingestion of heavy metals such as lead and bismuth are also associated with gingivitis.
The following prevent re-uptake of noradrenaline
1) isoprenaline
2) dopamine
3) clomipramine
4) propranolol
Pharmacology Answer: 3
Is a TCA- block neuronal uptake of noradrenaline and serotonin. and thus increase its conc. at synapse. they also block muscarinic, histaminergic, and adrenergic receptor
Which of the following antihypertensive drugs should not be used in a patient on Lithium in order to prevent Lithium Toxicity?
1) Clonidine
2) Beta blockers
3) Calcium Channel Blockers
4) Diuretics
Pharmacology Answer: 4
Diuretics increase sodium loss in urine and increase lithium retention. Hence they should not be used in patients on Lithium.
Chelating agent contraindicated in iron and cadmium poisoning
1) Penicillamine
2) Des ferroxamine
3) EDTA
4) BAL
Pharmacology Answer: 4
Dimercaprol (British antilewisite; BAL)
1. Poisoning by As, Hg, Au, Bi, Ni, Sb: it is administered i.m., 5 mg/kg stat, followed by 2-3 mg/kg every 4 – 8 hours for 2 days, then once or twice a day for 10 days. It is partly oxidized and glucuronide conjugated, but mainly excreted as such in 4 – 6 hours. Earlier the treatment is instituted, the better it is. Because the dimercaprolmetal complex dissociates faster in acidic urine and the released metal can damage the kidney, urine is alkalinized during dimercaprol therapy.
2. As an adjuvant to Cal. Disod. Edentate in lead poisoning.
3. As an adjuvant to penicillamine in Cu poisoning and in Wilson’s disease – 300 mg/day i.m. for 10 days every second month.
It is contraindicated in iron and cadmium poisoning, because the dimercaprol-Fe and dimercaprol-Cd complex is itself toxic.
The main excitatory neuro transmitter in CNS is
1) Glycine
2) Acetyl choline
3) Aspartate
4) Glutamate
Pharmacology Answer: 2
The chemical compound acetylcholine (ACh) is a neurotransmitter in both the peripheral nervous system (PNS)and central nervous system (CNS) in many organisms including humans. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmiter used in the somatic nervous system.
Dopamine is preferred in treatment of shock because of
1) Renal Vasodilatory effect
2) Increased Cardiac Output
3) Peripheral Vasoconstriction
4) Prolonged action
Pharmacology Answer: 1
Dopamine as a first line of drug in patients with shock
Dopamine in low doses can dilate renal vasculature therefore maintaining glomerular filtration.
Activates adenylate cyclase - cAMP – relaxation of vascular smooth muscle
Which of the following statement is not true about diuretics:
1) Acetazolamide is a carbonic acid anhydrase stimulant
2) Thiazides act on cortical diluting segment of loop of Henle
3) Frusemide is a high ceiling diuretic
4) Spironolactone is an aldosterone antagonist
Pharmacology Answer: 1
Acetazolamide is a carbonic acid anhydrase stimulant Acetazolamide, non-competitively (but reversibly) inhibits carbonic anhydrase in proximal tubular cells.