MDS PREP
Which of the following agents is used for the treatment of Thrombocytopenia secondary to myelosuppressive cancer chemotherapy?
1) Filgrastim
2) Sargramostim
3) Oprelvekin
4) Erythropoietin
Pharmacology Answer: 3
Oprelvekin (Interleukin 11) is the only agent approved by the FDA for treatment of thrombocytopenia secondary to myelosuppressive cancer chemotherapy
Filgrastim (G-CSF) and Sargramostim (GM-SCF) are used in the treatment of neutropenia
Erythropoietin is used in treatment of anemia
Which of the following fluoroquinolones does not require dose adjustment in a patient with creatinine clearance of < 50mg/min?
1) Ciprofloxacin
2) Trovafloxacin
3) Lomefloxacin
4) Sparfloxacin
Pharmacology Answer: 2
Fluoroquinolones that are excreted mainly by non renal mechanisms:
Pefloxacin Trovafloxacin Grepofloxacin Nalidixic acid
The effects of hypoglycemia is marked by
1) Warfarin
2) Beta blockers
3) Calcium channel blockers
4) Amino glycosides
Pharmacology Answer: 2
Beta blockers
Hypoglycemia can occur with beta-blockade because b2- adrenoceptors normally stimulate hepatic glycogen breakdown (glycogenolysis) and pancreatic release of glucagon, which work together to increase plasma glucose.
The most potent narcotic analgesic is
1) Morphine
2) Pethidine
3) Methadone
4) Pentazocine
Pharmacology Answer: 3
Methadone is a synthetic narcotic analgesic The other major synthetic narcotic is meperidine (Demerol). Narcotic analgesics derived from opium are morphine, heroin (diacetylmorphine), and codeine.
False statement regarding phenytoin is?
1) It is a teratogenic drug
2) Highly protein bound
3) Induces insulin secretion
4) Follows saturation kinetics
Pharmacology Answer: 3
Phenytoin inhibits insulin secretion and causes hyperglycemia.
Which of the following antibiotics shows an incidence of approximately 8% cross-allergencity with penicillins?
1) Bacitracin
2) Erythromycin
3) Cephalexin
4) Vancomycin
Pharmacology Answer: 3
Cephalosporins can cause allergic reactions in people with penicillin allergy. The overall rate of allergy to cephalosporins in people with penicillin allergy is approximately 5 to 10%, although rates may be higher for certain people. Allergic reactions to cephalosporins can be severe and even lifethreatening;
it is generally recommended that those allergic to penicillin avoid cephalosporins all together.
Syncope may be treated with any of the following drug except
1) Phenylephrine
2) Oxygen
3) Ephedrine
4) Isoproterenol
Pharmacology Answer: 4
Isoproterenol is used in the management of bronchospasm during anesthesia;
adjunctive treatment for shock.
Not a contraindication for epinephrine use is
1) Heart disease.
2) Hypersensitivity to drug.
3) Hyperthyroidism.
4) Liver disease.
Pharmacology Answer: 4
Adrenaline is contraindicated in hypertensive, hyperthyroid and angina patient.
Hypersensitivity to drug is absolute contraindication to any drug.