MDS PREP
The neuromuscular blocker that does not need reversal of action by neostigmine at the end of the operation is :
1) d–Tubocurarine
2) Doxacurium
3) Pipecuronium
4) Mivacurium
Pharmacology Answer: 4
Long acting non-depolarizing (competitive) NM blocking agents require reversal with neostigmine.
Mivacurium is the shortest acting NDMR. It does not require reversal due to its short duration of action.
Mivacurium can be used in day care surgery.
The drug currently in wide use for treating opioid dependent individuals
1. methadone
2. pentazocine
3. alphaprodine
4. meperidine
Pharmacology
Answer: 1
The drug currently in wide use for treating opioid dependent individuals is metahdone
Morphine can be used in all the following conditions except:
1) Head injury
2) Asthma
3) Hypothyroidism
4) Diabetes
Pharmacology Answer: 1
Morphine is contraindicated in head injury for the following reasons:
Causes carbondioxide retention – this in turn increases intracranial tension
Therapeutic doses can cause respiratory depression in head injury patients Vomiting, miosis and altered mentation caused by morphine can interfere with assessment of neurological status
Morphine should be avoided in those with bronchial asthma as it can precipitate an attack of asthma. But it is not contraindicated
The most potent narcotic analgesic is
1) Morphine
2) Pethidine
3) Methadone
4) Pentazocine
Pharmacology Answer: 3
Methadone is a synthetic narcotic analgesic The other major synthetic narcotic is meperidine (Demerol). Narcotic analgesics derived from opium are morphine, heroin (diacetylmorphine), and codeine.
Drug class causing free water clearance:
a) Diuretic
b) Saluretic
c) Uricosuric
d) Aquaretic
Pharmacology Answer: 4
Vasopressin antagonists like tolvaptan are aquaretics
Which of the following is used to decrease the toxicity of amphotericin B?
1) Dose reduction
2) Liposomal delivery systems
3) Supplementing glucose
4) Giving it along with flucytosine
Pharmacology Answer: 2
Liposomal delivery systems decrease the amount of free drug in the blood Infected cells interact with the liposomes, resulting in the release of amphotericin B at the site of action.
A medication that is associated with gingivitis
1) phenytoin
2) carbamazepine
3) propranolol
4) diazepam
Pharmacology Answer: 1
Gingivitis is a form of periodontal disease. Periodontal disease is when inflammation and infection destroy the tissues that support the teeth, including the gingiva (gums), the periodontal ligaments, and the tooth sockets (alveolar bone Malocclusion of teeth (misaligned teeth), rough edges of fillings, and ill fitting or unclean mouth appliances (such as orthodontic appliances, dentures, bridges, and crowns) can irritate the gums and increase the risk of gingivitis.
Medications such as phenytoin and birth control pills, and ingestion of heavy metals such as lead and bismuth are also associated with gingivitis.
The administration of penicillin G along with probenacid results in
1. increased excretion of probenacid in the feces and perspiration
2. increased excretion of probenacid in urine
3. increased metabolism of penicillin G
4. decreased renal excretion of penicillin G
Pharmacology Answer: 4
The administration of penicillin G along with probenacid results in decreased renal excretion of penicillin G