MDS PREP
Which receptors are implicated in anti emetic effects:
1) D2
2) V2
3) MU2
4) GABA
Pharmacology Answer: 2
CTZ rich in D2 and 5HT receptors
The most appropriate drug for treatment of generalized tonic-clonic (grand mal) is:
1) valproate
2) methylphenidate
3) ethosuximide
4) diazepam
Pharmacology Answer: 1
For generalized tonic-clonic seizures, phenytoin, carbamazepine, or valproate is the drug of choice.
Which of the following has a uricosuric action:
1) Allopurinol
2) Losartan
3) Ramipril
4) Atenolol
Pharmacology Answer: 2
Losartan has a uricosuric action in addition to being an angiotensin receptor blocker.
Allopurinol is a xanthine oxidase inhibitor which reduces the synthesis of uric acid.
The administration of barbiturates is contraindicated in :
1) Anxiety disorders
2) Acute intermittent prophyria
3) Kernicterus
4) Refractive status epilepticus
Pharmacology Answer: 2
Acute intermittent prophyria (AIP) : Barbiturates exacerbate it by inducing microsomal enzymes and d amino levulinic acid synthetase and increasing prophyrin synthesis.
Note: Contraindications of barbiturates : · Liver and kidney disease · Severe pulmonary insufficiency eg. Emphysema · Obstructive sleep apnoea
Which of the following is a Beta-1 selective blocker ?
1) propranolol
2) nadolol
3) pindolol
4) betaxolol
Pharmacology Answer: 4
Beta-1 selective blockers
These include atenolol and metoprolol (as well as betaxolol, bevantolol, and perhaps esmolol).
Non-selective beta blockers
propranolol
The drug of choice for the treatment of thyrotoxicosis during pregnancy is?
1 Carbimazole
2 Iodine therapy
3 Propylthiouracil
4 Metimazole
Pharmacology Answer: 3
Thyroid inhibitors
a) Inhibit hormone synthesis (anti thyroid drugs): Propylthiouracil, Methimazole, Carbimazole
b) Inhibit iodine trapping (ionic inhibitors): Thiocyanates, Perchlorates, Nitrates.
c) Inhibit hormone release: Iodine, NaI, Kl
d) Destroy thyroid tissue: Radioactive iodine
Drug implicated for prolonging QT interval in a premature baby is :
1) Domperidone
2) Metoclopramide
3) Cisapride
4) Omeprazole
Pharmacology Answer: 3
Cisapride can cause QT prolongation when administered along with drugs like ketoconazole which inhibit hepatic cytochrome p-450 CYP 3A4 enzyme.
A medication that reduces the rate of aqueous humor formation in acute glaucoma
1) phenothiazines
2) amphotericin B
3) Isoniazid
4) carbonic anhydrase inhibitors
Pharmacology Answer: 4
Carbonic anhydrase is found in erythrocytes, kidney, gut, ciliary body, choroid plexus, and glial cells.
Carbonic anhydrase inhibitors are used primarily as probes for studying renal transport mechanisms and in the treatment of glaucoma
When used to treat glaucoma, carbonic anhydrase inhibitors diminish the transport of HCO3 - and Na+ by the ciliary process, which limits intraocular pressure.
This reduces the formation of aqueous humor by up to 50%, thereby reducing the intraocular pressure. These agents can also limit CSF and endolymph formation.