MDS PREP
The principal chemical mediator of immediate phase, of acute inflammation is:
1. Serotonin
2. Histamine
3. Kinin-Kallikrein
4. Complement system
Pathology
Answer: 2
The principal chemical mediator of the immediate phase of acute inflammation
is Histamine. Here's a detailed explanation of the options given:
1. Serotonin: While serotonin is a vasoactive substance that can cause blood
vessels to constrict or dilate, it is not the primary mediator of the immediate
phase of acute inflammation. It is mainly associated with the regulation of
mood, appetite, and sleep. In the context of inflammation, it plays a minor role
compared to histamine.
2. Histamine: Histamine is indeed the correct answer. It is a potent chemical
mediator released from mast cells and basophils in response to injury or
antigenic stimulation. Upon release, histamine acts on blood vessels to cause
vasodilation, increased permeability, and increased blood flow to the injured
area, which are hallmark features of the immediate phase of acute inflammation.
This results in the cardinal signs of inflammation: redness (rubor), heat
(calor), swelling (tumor), and pain (dolor).
3. Kinin-Kallikrein system: The kinin-kallikrein system is another important
mediator of inflammation, but it is more involved in the later phases. When
activated, it results in the formation of kinins, such as bradykinin, which
contribute to increased vascular permeability and pain. However, it is not the
first line mediator in the immediate phase.
4. Complement system: The complement system is a group of proteins in the blood
that work with antibodies to destroy pathogens and trigger inflammation. It is a
key component of the innate immune response, but its activation and role are
more pronounced in the later stages of inflammation rather than the immediate
phase. The complement system is involved in the opsonization of pathogens,
recruitment of phagocytes, and the formation of the membrane attack complex,
which can lyse certain bacteria and cells.
The immediate phase of acute inflammation is characterized by the rapid response
to tissue injury, which includes vasoactive changes and increased vascular
permeability to allow fluid, cells, and proteins to move into the interstitial
space. Histamine is quickly released from mast cells and basophils and acts on
H1 receptors of blood vessels to induce vasodilation and increased permeability.
This leads to the early symptoms of inflammation, such as swelling, redness,
heat, and pain, and is crucial for the initiation of the inflammatory response
to protect the body from harm.
Slightly raised vesicles rupturing to form ulcers are a feature of
1) Rubeola
2) Rubella
3) Condyloma acuminatum
4) Chicken pox
Pathology Answer: 4
Chicken pox presents with multiple dermal lesions characteristically with vesicles, pustules which may secondarily ulcerate
Leucocytopenia is seen in
1. Influenza
2. Agranulocytosis
3. Liver cirrhosis
4. All of the above
Oral Pathology
Answer: 4
Leukocytopenia can be seen in influenza, agranulocytosis, and liver cirrhosis.
Bite cells are seen in -
1) G6PD deficiency
2) SCA
3) Hereditary spherocytosis
4) Trauma
General Pathology
Answer: 1
Bite cells are characteristic of G6PD deficiency, resulting from oxidative damage to red blood cells.
Commonest type of Basal cell carcinoma is -
1. Ulcerated
2. Cystic
3. Morphoeic
4. Pigmented
Pathology
Answer: 1
1. Noduloulcerative Basal Cell Carcinoma: This is the most common subtype of
BCC, making up about 60-70% of all cases. It typically appears as a slowly
growing, round to oval, pearly or translucent nodule with a central ulceration
that may bleed or ooze. The borders of the lesion are often not well-defined and
may have a rolled, pearly edge with telangiectasias (small, dilated blood
vessels).
2. Cystic Basal Cell Carcinoma: This subtype presents as a round, dome-shaped
lesion with a cystic or fluid-filled center. It is less common than the
noduloulcerative type, and it may be mistaken for a benign cyst or epidermoid
cyst.
3. Morphoeic Basal Cell Carcinoma: Also known as sclerosing or morpheaform BCC,
this type is characterized by a slowly growing, ill-defined, firm, plaque-like
lesion that can infiltrate deeply into the skin. It may have a whitish, waxy
appearance with a scar-like texture. Morphoeic BCC tends to be more aggressive
and can be challenging to diagnose due to its subtlety.
4. Pigmented Basal Cell Carcinoma: This is a less common variant of BCC,
accounting for approximately 6-15% of cases. It presents with pigmentation in
the lesion, which can be brown, blue, or black. The presence of pigment can make
it look similar to melanoma, another type of skin cancer, so a biopsy is often
necessary to confirm the diagnosis.
All of the following statements about the typical feature of a periapical
granuloma are true EXCEPT
1) It consists of proliferating granulation tissue
2) It can form only if the periapical bone is resorbed
3) It shows evidence of local antibody production
4) It results from immunologically mediated tissue damage
Oral Pathology Answer: 2
Periapical granulomas were diagnosed as well-circumscribed periapical
radiolucency measuring less than 1.5 cm in diameter, periapical cysts were
characterized by well-defined periapical radiolucency with sclerotic borders
measuring greater than 1.5 cm, and periapical abscesses were characterized by
ill-defined periapical radiolucency with diffuse margins.
While bone resorption can occur in the presence of a periapical granuloma, it
is not a prerequisite for its formation. A periapical granuloma can develop in
response to pulp necrosis or infection without necessarily requiring bone
resorption to occur first. The granuloma can form as a reaction to the
inflammatory process, regardless of the state of the surrounding bone.
X-rays are generated when a stream of electrons travelling from tungsten filament is suddenly stopped by its impact on the
1. Gruntled filament
2. Anodic tungsten target
3. Cathodic tungsten target
4. Molybdenum lining of anode
Oral Pathology
Answer: 2
X-rays are generated when a stream of electrons traveling from the tungsten filament is suddenly stopped by its impact on the anodic tungsten target.
Which of the following disease are common in ashkenazi jews
1. Hand-Schuller-Christian disease and Letterer-Siwe disease
2. Gaucher"s disease and Niemann-Pick disease
3. Amelogenesis imperfecta and dentinogenesis imperfecta
4. Achondroplasia and Marfan"s syndrome
Oral Pathology
Answer: 2
Gaucher's disease and Niemann-Pick disease are common in Ashkenazi Jews.