MDS PREP
What is the typical age of onset for Huntington's disease?
(1) Childhood
(2) Fourth or fifth decade
(3) Seventh or eighth decade
(4) Second or third decade
Huntington's disease typically begins in the fourth or fifth decade of life. It is an autosomal dominant disorder that affects both men and women, and the symptoms include chorea, behavioral disturbances, and cognitive decline. While there is a wide range in age of onset, the average age of symptom manifestation is around 30 to 50 years.
Which of the following is NOT a lifestyle risk factor for atherosclerosis?
1) Obesity (BMI ? 30 kg/m2)
2) Physical inactivity
3) High LDL cholesterol
4) Impaired fasting glucose
While high LDL cholesterol is a significant risk factor for atherosclerosis, it is not a lifestyle factor. It is a metabolic condition that can be influenced by diet and physical activity.
Malherbe"s epithelioma characterised by all except
1) Benign calcifying epithelioma
2) Common in adults
3) Solitary, hard tumours
4) Mostly on the neck, face, arms
Oral medicine
Answer: 2
Malherbe's epithelioma, also known as calcifying epithelioma, is typically a benign tumor that is more common in children and young adults rather than adults. It is characterized by solitary, hard tumors that are often found on the neck, face, and arms. The other options accurately describe the characteristics of Malherbe's epithelioma.
A 35-year-old male comes to the clinic complaining of fever and malaise. Blood tests reveal a positive reaction to a tuberculin skin test. What is the most likely diagnosis?
(1) Active tuberculosis (TB)
(2) Latent TB infection
(3) BCG vaccine failure
(4) TB meningitis
A positive tuberculin skin test indicates a past exposure to TB bacteria, which has led to the development of an immune response. Latent TB infection is asymptomatic and does not imply active disease. Further tests are needed to rule out active TB.
What is the initial event in a vasovagal syncope episode?
1) Bradycardia
2) Tachycardia
3) Decrease in peripheral vascular resistance
4) Increased catecholamine release
The initial event in a vasovagal syncope episode is an increase in catecholamine release, leading to a decrease in peripheral vascular resistance and tachycardia.
In a patient with nephrotic syndrome, which of the following is true regarding plasma cholesterol levels?
(1) Plasma cholesterol levels are decreased due to increased LDL receptors in the liver.
(2) Plasma cholesterol levels are increased due to the loss of cholesterol in urine.
(3) Plasma cholesterol levels are normal as the condition is unrelated to lipid metabolism.
(4) Plasma cholesterol levels are decreased due to increased hepatic synthesis of bile salts.
Nephrotic syndrome is associated with hyperlipidemia, particularly increased levels of LDL and cholesterol. The underlying mechanism involves the loss of albumin in the urine, which leads to hypoalbuminemia. This causes an increased synthesis of very low-density lipoproteins (VLDL) by the liver to compensate for the loss of oncotic pressure. Additionally, the loss of proteins that normally bind to cholesterol in the blood, such as lipoproteins, results in decreased clearance of LDL.
A 25-year-old pregnant woman presents with complaints of mild abdominal pain and diarrhea. Her blood pressure is 90/60 mmHg and her urine output is decreased. What is the most likely cause of her symptoms?
(1) Gestational diabetes
(2) Urinary tract infection
(3) Hyperemesis gravidarum
(4) Intestinal obstruction
Hyperemesis gravidarum is severe nausea and vomiting during pregnancy that can lead to dehydration and electrolyte imbalances. The patient's symptoms and signs of dehydration (low blood pressure and decreased urine output) support this diagnosis.
What is the target INR range for a patient on warfarin therapy to undergo minor oral surgery?
(1) Less than 2
(2) 2-3
(3) 3-4
(4) Less than 1.5
For a patient on warfarin therapy, the target INR (International Normalized Ratio) for undergoing minor oral surgery is typically 2-3. This range provides adequate thromboprophylaxis while minimizing the risk of excessive bleeding. However, the decision to proceed with surgery should be made on a case-by-case basis, considering the patient's overall health and surgical risks.