General Pathology

Rocky Mountain Spotted Fever (Spotted Fever; Tick Fever; Tick Typhus) An acute febrile disease caused by Rickettsia rickettsii and transmitted by ixodid ticks, producing high fever, cough, and rash. Symptoms and Signs The incubation period averages 7 days but varies from 3 to 12 days; the shorter the incubation period, the more severe the infection. Onset is abrupt, with severe headache, chills, prostration, and muscular pains. Fever reaches 39.5 or 40&deg…

OEDEMA  Excessive accumulation of fluid in the extra vascular compartment (intersttitial tissues). This includes ascites (peritoneal sac), hydrothorax (pleural cavity) hydropericardium (pericardial space) and anasarca (generalised) Factors which tend to accumulate interstitial fluid are: - Intravascular hydrostatic pressure - Interstitial osmotic pressure. - Defective lymphatic drainage. - Increased capillary permeability. Factors that draw…

Autoimmune(acquired) Haemolytic anaemia Auto antibodies are usually Ig g type (may be Ig M or Ig A). They may or may not bind complement and may be active in warm or cold temperature  They may be complete (agggIutinating) or incomplete. Haemolysis s may be intravascular  due to destruction of the antibody coated cells by RE system. Causes: a. Idiopathic b. Secondary to o    Drugs - Methyldopa, Mefanamic acid o   &nbsp…

Monocytosis: Causes -Infections causing lymphocytosis, especialy tuberculosis and typhoid.  -Monocytic leukaemia. -Some auto immune diseases.

HAEMORRHAGIC DISORDERS Normal homeostasis depends on  -Capillary integrity and tissue support. - Platelets; number and function (a) For integrity of capillary endothelium and platelet plug by adhesion and aggregation (b) Vasoactive substances for vasoconstriction (c) Platelet factor for coagulation. (d) clot retraction. - Fibrinolytic system(mainly Plasmin) : which keeps the coagulatian system in check. Coagulation disorders These …