Pharmacology

Metabolism Hepatic Drug-Metabolizing Enzymes:  most drug metabolism in the liverperformed by the hepatic microsomal enzyme system. Therapeutic Consequences of Drug Metabolism - Accelerated Renal Drug Excretion:  The most important consequence of drug metabolism is the promotion of renal drug excretion.  Metabolism makes it possible for the kidney to excrete many drugs that it otherwise could not. - Drug Inactivation - Increased Therapeutic …

Megltinides nateglinide repaglinide Mechanism binds to K+ channels on β-cells → postprandial insulin release Clinical use type 2 diabetes mellitus may be used as monotherapy, or in combination with metformin…

NATURAL ANTICOAGULANTS:        1. PGI-2.        2. Antithrombin.        3. Protein-C.        4. TFPI.        5. Heparin.        6. Fibrinolytic system.

DIAGNOSIS Affective disorders: I. unipolar depression – depression alone bipolar affective disorder – alternating II. bipolar affective disorder – alternating depression and mania Diagnosis is based on  At least five of the following for 2 weeks I. Depressed mood most of the day II. Markedly diminished interest or pleasureII. Markedly diminished interest or pleasure III. Significant weight loss or weight IV. Insomnia or hypersom…

Meperidine (Demerol) Meperidine is a phenylpiperidine and has a number of congeners. It is mostly effective in the CNS and bowel Produces analgesia, sedation, euphoria and respiratory depression. Less potent than morphine, 80-100 mg meperidine equals 10 mg morphine. Shorter duration of action than morphine (2-4 hrs). Meperidine has greater excitatory activity than does morphine and toxicity may lead to convulsions. Meperidine appears to have some at…