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Anatomy

Endochondral ossification

  • A cartilage model exists
  • Through intramembraneous ossification in the perichondrium a collar of bone forms around the middle part of the cartilage model
  • The perichondrium change to a periostium
  • The bone collar cuts off the nutrient and oxygen supply to the chondrocytes in the cartilage model
  • The chondrocytes then increase in size and resorb the surrounding cartilage matrix until only thin vertical septae of matrix are left over
  • These thin plates then calcify after which the chondrocytes die
  • The osteoclasts make holes in the bone collar through which blood vessels can now enter the cavities left behind by the chondrocytes
  • With the blood vessels osteoprogenitor cells enter the tissue
  • They position themselves on the calcified cartilage septae, change into osteoblasts and start to deposit bone to form trabeculae
  • In the mean time the periosteum is depositing bone on the outside of the bone collar making it thicker and thicker
  • The trabeculae,consisting of a core of calcified cartilage with bone deposited on top of it, are eventually resorbed by osteoclasts to form the marrow cavity
  • The area where this happens is the primary ossification centre and lies in what is called the diaphysis (shaft)
  • This process spreads in two directions towards the two ends of the bone the epiphysis
  • In the two ends (heads) of the bone a similar process takes place
  • A secondary ossification centre develops from where ossification spreads radially
  • Here no bone collar forms
  • The outer layer of the original cartilage remains behind to form the articulating cartilage
  • Between the primary and the secondary ossification centers two epiphyseal cartilage plates remain
  • This is where the bone grows in length
  • From the epiphyseal cartilage plate towards the diaphysis a number of zones can be identified:

 Resting zone of cartilage

 Hyaline cartilage

 Proliferation zone

 Chondrocytes divide to form columns of cells that mature.

Hypertrophic cartilage zone

 Chondrocytes become larger, accumulate glycogen, resorb the surrounding matrix so that only thin septae of cartilage remain 

Calcification and degeneration zone

The thin septae of cartilage become calcified.

The calsified septae cut off the nutrient supply to the chondrocytes so subsequently they die.

Ossification zone.

Osteoclasts make openings in the bone collar through which blood vessels then invade the spaces left vacant by the chondrocytes that died.

Osteoprogenitor cells come in with the blood and position themselves on the calcified cartilage

septae, change into osteoblasts and start to deposit bone.

 When osteoblasts become trapped in bone they change to osteocytes.

Growth and remodeling of bone

Long bones become longer because of growth at the epiphyseal plates

They become wider because of bone formed by the periosteum

The marrow cavity becomes bigger because of resorbtion by the osteoclasts

Fracture repair

When bone is fractured a blood clot forms

 Macrophages then remove the clot, remaining osteocytes and damaged bone matrix

The periosteum and endosteum produce osteoprogenitor cells that form a cellular tissue in the fracture area

 Intramembranous and endochondral ossification then take place in this area forming trabeculae.

Trabeculae connect the two ends of the broken bone to form a callus

Remodelling then takes place to restore the bone as it was

Joints

The capsule of a joint seals off the articular cavity,  

The capsule has two layers

 fibrous (outer)

synovial (inner)

The synovial layer is lined by squamous or cuboidal epithelial cells,  Under this layer is a layer of loose or dense CT, The lining cells consists of two types:

- A cells

- B cells

They secrete the synovial fluid

They are different stages of the same cell, They are also phagocytic., The articular cartilage has fibres that run perpendicular to the bone and then turn to run parallel to the surface

 

Skull bones

 

  • 26 bones: 22 bones + hyoid (small bone in neck for swallowing) + 3 auditory ossicles (middle ear: incus, malleus, stapes)
  • 21 bones: tightly connected; mandible is freely mobile at temperomandibular joint (synovial)
  • connective-tissue interface b/w bones = suture
  • bones – mandible = cranium
  • cranium
    • neurocranium: covers brain anteriorly, laterally and posteriorly
    • brain supported by bones of basicranium
      • also contributes to interorbital region; b/w eyes and superior to nasal passages
    • viscerocranium/splanchnocranium: bones of face
  • sutures
    • coronal: separates frontal from parietals
    • sagittal: separates two parietal bones
    • lambdoidal: separates parietal form occipital
    • squamosal: b/w temporal and parietal; overlapping sutures
    • At birth: 2 frontal bones which eventually fuse; metopic suture disappears

Cranial Cavities: 5 major cavities

            Endocranial, left and right orbits, nasal cavities, oral cavity, middle ear cavities

Endocranial cavity

  • contains brain, meninges, cerebrospinal fluid, brain’s vascular supply and most proximal portion of cranial nerves
  • enclosed by neurocranium and basicranium
  • basicranium: foramina for neurovascular bundles
  • foramen magnum: spinal cord exit
  • floor of endocranial cavity divide into fossae
    • anterior: frontal lobes of brain
    • middle: pair temporal lobes
    • posterior: cerebellum and brainstem

​​​​​​​The Tongue

  • The tongue (L. lingua; G. glossa) is a highly mobile muscular organ that can vary greatly in shape.
  • It consists of three parts, a root, body, and tip.
  • The tongue is concerned with mastication, taste, deglutition (swallowing), articulation (speech), and oral cleansing.
  • Its main functions are squeezing food into the pharynx when swallowing, and forming words during speech.

The Nose

  • The nose is the superior part of the respiratory tract and contains the peripheral organ of smell.
  • It is divided into right and left nasal cavities by the nasal septum.
  • The nasal cavity is divided into the olfactory area and the respiratory area.

The Laryngopharynx

  • The laryngeal part of the pharynx lies posterior to the larynx.
  • It extends from the superior border of the epiglottis to the inferior border of the cricoid cartilage, where it narrows to become continuous with the oesophagus.
  • Posteriorly, the laryngopharynx is related to the bodies of C4 to C6 vertebrae.
  • Its posterior and lateral walls are formed by the middle and inferior constrictor muscles, with the palatopharyngeus and stylopharyngeus internally.
  • The laryngopharynx communicates with the larynx through the aditus or inlet of the larynx.
  • The piriform recess is a small, pear-shaped depression of the laryngopharyngeal cavity on each side of the inlet of the larynx.

Innervation of the Skin

  • Innervation of the skin is mainly through the three branches of the trigeminal nerve (CN V).
  • Some skin over the angle of the mandible and anterior and posterior of the auricle is supplied by the great auricular nerve from the cervical plexus.
  • Some cutaneous branches of the auricular branch of the facial nerve also supplies skin on both sides of the auricle.
  • The trigeminal nerve is the general sensory nerve to the head, particularly the face, and is the motor nerve to the muscles of mastication.

The Ophthalmic Nerve

  • This is the superior division of the trigeminal nerve, the smallest of the three branches and is wholly sensory.
  • The ophthalmic nerve divides into three branches: the nasociliary, frontal and lacrimal just before entering the orbit through the superior orbital fissure.
  • The nasociliary nerve supplies the tip of the nose through the external nasal branch of the anterior ethmoidal nerve.
  • The frontal nerve is the direct continuation of CN V1 and divides into two branches, the supraorbital and supratrochlear.
  • The supratrochlear nerve supplies the middle part of the forehead.
  • The supraorbital nerve supplies the lateral part and the front of the scalp.
  • The lacrimal nerve, the smallest of the main ophthalmic branches, emerges over the superolateral orbital margin to supply the lacrimal gland and the lateral part of the upper eyelid.

The Maxillary Nerve

  • This is the intermediate division of the trigeminal nerve.
  • It has three cutaneous branches.
  • The infraorbital nerve is the largest terminal branch of the maxillary nerve.
  • It passes through the infraorbital foramen and breaks up into branches that supplies the skin on the lateral aspect of the nose, upper lip and lower eyelid.
  • The zygomaticofacial nerve, a small branch of the maxillary, emerges from the zygomatic bone from a foramen with the same name.
  • It supplies the skin over the zygomatic bone.
  • The zygomaticotemporal nerve emerges from the zygomatic bone from foramen of the same name.
  • It supplies the skin over the temporal region.

The Mandibular Nerve

  • This is the inferior division of the trigeminal nerve.
  • Of the three division of the trigeminal nerve, CN V3 is the only one that carries motor fibres (to the muscles of mastication).
  • The main sensory branches of the mandibular nerve are the buccal, auriculotemporal, inferior alveolar and lingual nerves.
  • The buccal nerve is a small branch of the mandibular that emerges from deep to the ramus of the mandible.
  • It supplies the skin of the cheek over the buccinator muscle, the mucous membrane lining the cheek, and the buccal surface of the gingiva.
  • The auriculotemporal nerve passes medially to the neck of the mandible and then turns superiorly, posterior to its head and anterior to the auricle. It then crosses over the root of the zygomatic process of the temporal bone, deep to the superficial temporal artery.
  • It supplies the auricle, external acoustic meatus, tympanic membrane, and the skin in the temporal region.
  • The inferior alveolar nerve is the large terminal branch of the posterior division of the mandibular nerve (the lingual nerve is the other terminal branch).
  • It enters the mandible through the mandibular foramen to the mandibular canal. In the canal, it gives branches to the mandibular teeth.
  • Opposite the mental foramen, this nerve divides into the mental nerve and the incisive nerve.
  • The incisive nerve supplies the incisor teeth, the adjacent gingiva and the mucosa of the lower lip.
  • The mental nerve emerges from the mental foramen and supplies the skin of the chin and the skin and mucous membrane of the lower lip and gingiva.
  • The lingual nerve is the smaller terminal branch of the mandibular nerve.
  • It supplies the general sensory fibres to the anterior two-thirds of the tongue, the floor of the mouth and the gingivae of the mandibular teeth.

The Hard Palate

  • The anterior bony part of the palate is formed by the palatine process of the maxillae and the horizontal plates of the palatine bones.
  • Anteriorly and laterally, the hard palate is bounded by the alveolar processes and the gingivae.
  • Posteriorly, the hard palate is continuous with the soft palate.
  • The incisive foramen is the mouth of the incisive canal.
  • This foramen is located posterior to the maxillary central incisor teeth.
  • This foramen is the common opening for the right and left incisive canals.
  • The incisive canal and foramen transmit the nasopalatine nerve and the terminal branches of the sphenopalatine artery.
  • Medial to the third molar tooth, the greater palatine foramen pierces the lateral border of the bony palate.
  • The greater palatine vessels and nerve emerge from this foramen and run anteriorly into two grooves on the palate.
  • The lesser palatine foramen transmits the lesser palatine nerve and vessels.
  • This runs to the soft palate and adjacent structures.

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