NEET MDS Lessons
Anatomy
EPITHELIUMS
Epithelial Tissue Epithelial tissue covers surfaces, usually has a basement membrane, has little extracellular material, and has no blood vessels. A basement membrane attaches the epithelial cells to underlying tissues. Most epithelia have a free surface, which is not in contact with other cells. Epithelia are classified according to the number of cell layers and the shape of the cells.
- Epitheliums contain no blood vessels. There is normally an underlying layer of connective tissue
- Almost all epitheliums lie on a basement membrane.The basement membrane consists of a basal lamina and reticular lamina. The reticular lamina is connected to the basal lamina by anchoring fibrils. The reticular lamina may be absent in which case the basement membrane consist only of a basal lamina. The basal lamina consists of a - lamina densa in the middle (physical barrier) with a lamina lucida on both sides (+charge barrier),The basement membrane is absent in ependymal cells.The basement membrane is not continuous in sinusoidal capillaries.
- Epitheliums always line or cover something
- Epithelial cells lie close together with little intercellular space
- Epithelial cells are strongly connected to one another especially those epitheliums that are subjected to mechanical forces.
Functions of Epithelium:
→ Simple epithelium involved with diffusion, filtration, secretion, or absorption
→ Stratified epithelium protects from abrasion
→ Squamous cells function in diffusion or filtration
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Articulations
Classified according to their structure, composition,and movability
• Fibrous joints-surfaces of bones almost in direct contact with limited movement
o Syndesmosis-two bones united by interosseous ligaments
o Sutures-serrated margins of bones united by a thin layer of fibrous tissue
o Gomphosis-insertion of a cone-shaped process into a socket• Cartilaginous joints-no joint cavity and contiguous bones united by cartilage
o Synchondrosis-ends of two bones approximated by hyaline cartilage
o Symphyses-approximating bone surfaces connected by fibrocartilage• Synovial joints-approximating bone surfaces covered with cartilage; may be separated by a disk; attached by ligaments
o Hinge-permits motion in one plane only
o Pivot-permits rotary movement in which a ring rotates around a central axis
o Saddle-opposing surfaces are convexconcave. allowing great freedom of motion
o Ball and socket - capable of movement in an infinite number of axes; rounded head of one bone moves in a cuplike cavity of the approximating boneBursae
• Sacs filled with synovial fluid that are present where tendons rub against bone or where skjn rubs across bone
• Some bursae communicate with a joint cavity
• Prominent bursae found at the elbow. hip, and knee'Movements
• Gliding
o Simplest kind of motion in a joint
o Movement on a joint that does not involve any angular or rotary motions
• Flexion-decreases the angle formed by the union of two bones
• Extension-increases the angle formed by the union of two bones
• Abduction-occurs by moving part of the appendicular skeleton away from the median plane of the body
• Adduction-occurs by moving part of the appendicular skeleton toward the median plane of the body
• Circumduction
o Occurs in ball-and-socket joints
o Circumscribes the conic space of one bone by the other bone
• Rotation-turning on an axis without being displaced from that axis
Cardiac Muscle
Fibres anastomose through cross bridges
Fibres are short, connected end to end at intercalated discs, also striated, contract automatically
Light microscopic Structure:
Short fibres connected at intercalated disks, 85 - 100 µm long, 15 µm
same bands as in skeletal muscle, 1 or 2 nuclei - oval and central, in perinuclear area is a sarcoplasmic reticulum, intercalated discs lie at the Z line
Electron microscopic structure:
Between myofibrils lie the mitochondria, 2,5 µm long mitochondria, dense cristae
and are as long as the sarcomere, fibres have more glycogen than skeletal muscle fibres
myofilaments, actin and myosin are the same as in skeletal muscle, the sarcoplasmic reticulum differs in that there is no terminal sisterna. The sarcotubules end in little feet that
sit on the T-tubule
Intercalated Disc:
on Z lines, fibres interdigitate,
3 types of junctions in the disc
Transverse Part:
zonula adherens
desmosomes
Lateral Part:
Gap junctions (nexus) - for impulse transfer
Mechanism of Contraction:
slide - ratchet like in skeletal muscle, certain fibres are modified for conduction, Impulses spread from cell to cell through gap junctions, Purkinje cells are found in the AV bundle
they have less myofibrils, lots of glycogen and intercalated discs
Connective tissue coverings:
Only endomycium in cardiac muscle, Blood vessels, lymph vessels and nerves lie in the endomycium
Innervation of the Pharynx
- The motor and most of the sensory supply of the pharynx is derived from the pharyngeal plexus of nerves on the surface of the pharynx.
- The plexus is formed by pharyngeal branches of the vagus (CN X) and glossopharyngeal (CN IX) nerves, and by sympathetic branches for the superior cervical ganglion.
- The motor fibres in the pharyngeal plexus are derived from the cranial root of accessory nerve (CN XI), and are carried by the vagus nerve to all muscles of the pharynx and soft palate.
- The exceptions are stylopharyngeus (supplied by CN IX) and the tensor veli palatini (supplied by CN V3).
Smooth Muscle
Light microscopic Structure:
cells - long - spindle shaped, nucleus lies in the widest widest part of the fiber, when the fiber contract the nucleus become folded, 30 - 200 µm long,between fibres lie endomycium
Electron microscopic structure:
Mitochondria, ribosomes, golgi, rough EPR, myofilaments are present but no sarcomeres and no Z lines,thin filaments - actin and tropomyosin (7nm), thick filaments - myosin (17nmØ)
- intermediate filaments (10 nm)
- actin and myosin overlap more than in skeletal muscle and can therefore contract more
A rudimentary sacroplasmic reticulum is present in the form of invaginations on the surface called caveolae , So there are no T-tubules, Cells communicate through gap junctions.
Dense bodies
Filaments are attached to dense bodies which take the place of the Z line in skeletal muscle
There are two types of dense bodies - cytoplasmic and membrane
contains a percentage actinin (like the Z line)
dense bodies transmit contractile force to adjacent fibres
Arrangement:
Fibres can be single or in groups, normally arranged in sheaths, In the GIT are 2 or 3 layers
Nerve supply:
2 types:
Where it is arranged in layers a few fibres are innervated together
impulse spread through the gap junctions between fibres (slow contraction)
In the iris and the vas deferens each fiber is individually supplied (quick contraction)
Muscles Around the Eyelids
- The function of the eyelid (L. palpebrae) is to protect the eye from injury and excessive light. It also keeps the cornea moist.
The Orbicularis Oculi Muscle
- This is the sphincter muscle of the eye.
- Its fibres sweep in concentric circles around the orbital margin and eyelids.
- It narrows the eye and helps the flow of tears from the lacrimal sac.
- This muscle has 3 parts: (1) a thick orbital part for closing the eyes to protect then from light and dust; (2) a thin palpebral part for closing the eyelids lightly to keep the cornea from drying; and (3) a lacrimal part for drawing the eyelids and lacrimal punta medially.
- When all three parts of the orbicularis oculi contract, the eyes are firmly closed and the adjacent skin becomes wrinkled.
- The zygomatic branch of the facial nerve (CN VII) supplies it.
The Levator Palpebrae Superioris Muscle
- This muscle raises the upper eyelid to open the palpebral fissure.
- It is supplied by the oculomotor nerve (CN III).
- This is the posterior curtain-like part, and has no bony support. It does, however, contain a membranous aponeurosis.
- The soft palate, or velum palatinum (L. velum, veil), is a movable, fibromuscular fold that is attached to the posterior edge of the hard palate.
- It extends posteroinferiorly to a curved free margin from which hangs a conical process, the uvula (L. uva, grape).
- The soft palate separates the nasopharynx superiorly and the oropharynx inferiorly.
- During swallowing the soft palate moves posteriorly against the wall of the pharynx, preventing the regurgitation of food into the nasal cavity.
- Laterally, the soft palate is continuous with the wall of the pharynx and is joined to the tongue and pharynx by the palatoglossal and palatopharyngeal folds.
- The soft palate is strengthened by the palatine aponeurosis, formed by the expanded tendon of the tensor veli palatini muscle.
- This aponeurosis attaches to the posterior margin of the hard palate.